High performance liquid chromatography of mycotoxin metabolites in human urine.

abstract：:In methanol intoxication, increased levels of the metabolite formate are associated with metabolic acidosis and an increased risk for ocular and neurological dysfunction. A simple method for plasma formate measurement by adaptation of a manual enzymatic assay to a Cobas Mira S analyzer is presented. Six microliters of...

journal_title：Journal of analytical toxicology

authors： Blomme B,Lheureux P,Gerlo E,Maes V

更新日期：2001-03-01 00:00:00

abstract：:At the end of 2010, the U.S. Drug Enforcement Administration (DEA) used its emergency scheduling authority to temporarily control five chemicals, JWH-018, JWH-073, JWH-200, CP-47497, and cannabicyclohexanol (CP-47497 C8), often referred to as "Spice", K2, or "synthetic cannabinoids" because of their reported cannabis-...

journal_title：Journal of analytical toxicology

authors： Coulter C,Garnier M,Moore C

更新日期：2011-09-01 00:00:00

abstract：:In December 2019, unusual cases of acute renal failure with neurological changes were observed in the State of Minas Gerais, Brazil. Criminal investigations indicated cases of intoxication after consumption of beers contaminated with diethylene glycol (DEG). The elimination of DEG by the body is fast, but its metaboli...

journal_title：Journal of analytical toxicology

authors： Goulart COL,Bordoni LS,Nascentes CC,Costa LM

更新日期：2020-12-03 00:00:00

abstract：:A modification of the Syva EMIT-tox Serum Barbiturate Assay was developed to provide a rapid and practical method for quantitating serum barbiturates. Standard curves for eight selected barbiturates were run using specific sets of standards for each. Correlation coefficients, slopes, and y-intercepts for the curves of...

journal_title：Journal of analytical toxicology

authors： Watson AT,Manno JE,Manno BR

更新日期：1983-11-01 00:00:00

abstract：:Postmortem redistribution (PMR) constitutes a multifaceted process, which complicates the interpretation of drug concentrations by forensic toxicologists. The present study aimed to apply quantitative structure-activity relationship (QSAR) analysis for modeling PMR data of structurally related drugs, 10 benzodiazepine...

journal_title：Journal of analytical toxicology

authors： Giaginis C,Tsantili-Kakoulidou A,Theocharis S

更新日期：2014-06-01 00:00:00

abstract：:In this study, the relationships between the concentrations of R/S-methamphetamine (MA) and its metabolite R/S-amphetamine (AP), the AP/MA ratio in hair samples, and MA dependence were investigated by performing segmental hair analysis in MA users. Authentic hair samples collected from 10 chronic MA abusers were cut i...

journal_title：Journal of analytical toxicology

authors： Wang T,Shen B,Wu H,Gu J,Shen M,Xiang P

更新日期：2020-07-31 00:00:00

abstract：:Confirmation of drugs of abuse by gas chromatography-mass spectrometry (GC-MS) is the most time-consuming process used by drug-testing laboratories. Cost effectiveness and competitive turnaround times for testing results demand fast, efficient, and reliable extraction methods. We applied the Cerex Polycrom-THC solid-p...

journal_title：Journal of analytical toxicology

authors： Crockett DK,Nelson G,Dimson P,Urry FM

更新日期：2000-05-01 00:00:00

abstract：:Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins c...

journal_title：Journal of analytical toxicology

authors： Zheng S,Yuan X,Wang W,Liang C,Cao F,Zhang R

更新日期：2016-06-01 00:00:00

abstract：:As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as flunitrazepam in Taiwan. Alleged misuses of this substance h...

journal_title：Journal of analytical toxicology

authors： Lin DL,Huang TY,Liu HC,Yin RM

更新日期：2005-03-01 00:00:00

abstract：:3-Fluorophenmetrazine (3-FPM) is a stimulant-like novel psychoactive substance (NPS) and fluorinated analog of phenmetrazine that has recently appeared on the recreational drug market, with limited published information. Likewise, the synthetic opioid U-47700 has gained popularity among recreational drug users and is ...

journal_title：Journal of analytical toxicology

authors： Ellefsen KN,Taylor EA,Simmons P,Willoughby V,Hall BJ

更新日期：2017-11-01 00:00:00

abstract：:A method is presented for the extraction and screening of basic and neutral drugs, including amphetamines. Two milliliters of blood are buffered to pH 9.0 and extracted with n-chlorobutane. Underivatized extracts are analyzed simultaneously on two complementary capillary columns placed together in one injection port u...

journal_title：Journal of analytical toxicology

authors： Watts VW,Simonick TF

更新日期：1986-09-01 00:00:00

abstract：:A sensitive and specific method for the quantitative determination of D,L-methadone (MD) and its metabolites, D,L-2-ethyl-1,5-dimethyl-3, 3-diphenylpyrrolinium (EDDP) and D,L-2-ethyl-5-methyl-3, 3-diphenyl-1-pyrroline (EMDP), in hair has been developed. Deuterated internal standards of MD, EMDP, and EDDP were added to...

journal_title：Journal of analytical toxicology

authors： Wilkins DG,Nagasawa PR,Gygi SP,Foltz RL,Rollins DE

更新日期：1996-10-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of 25 common pharmaceuticals in whole blood. The selected pharmaceuticals represent the most frequently detected drugs in our forensic laboratory with basic properties such as analgesics, antid...

journal_title：Journal of analytical toxicology

authors： Nielsen MK,Johansen SS

更新日期：2012-09-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:Continuing our previous studies analyzing drugs of abuse in municipal wastewater, a method was developed for the analysis of opiates in wastewater samples using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS). Eight opiate drugs and metabolites were analyzed including codeine, hydrocodone, hydro...

journal_title：Journal of analytical toxicology

authors： Gul W,Stamper B,Godfrey M,Gul SW,ElSohly MA

更新日期：2016-06-01 00:00:00

abstract：:A rapid and sensitive solid-phase extraction method for the lysergic acid diethylamide (LSD) metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) was developed for use in a forensic laboratory. The method uses a positive-pressure manifold anion-exchange polymer-based solid-phase extraction with subsequent analysis by liquid chrom...

journal_title：Journal of analytical toxicology

authors： Horn CK,Klette KL,Stout PR

更新日期：2003-10-01 00:00:00

abstract：:This case report presents three unrelated children found to have heroin and/or fentanyl in their systems after general unknown systematic toxicological analysis (STA). The first case involves an 11-month-old male found unresponsive at their residence. The scene response suggested a potentially unsafe sleeping conditio...

journal_title：Journal of analytical toxicology

authors： DeRienz RT,Baker DD,Kelly NE,Mullins AM,Barnett RY,Hobbs JM,Daniels JA,Harshbarger KE,Ortiz AM

更新日期：2018-10-01 00:00:00

abstract：:The National Institute of Standards and Technology (formerly the National Bureau of Standards), in cooperation with the College of American Pathologists (CAP), has certified the concentrations of phencyclidine (PCP) in two new reference materials (RMs). One of these materials is Standard Reference Material (SRM) 1511,...

journal_title：Journal of analytical toxicology

authors： Tai SS,Christensen RG,Coakley K,Ellerbe P,Long T,Welch MJ

更新日期：1996-01-01 00:00:00

abstract：:We present data from the analysis of the alcohol content of 391 beers and malt beverages available for sale in the State of Washington. The beverages were tested by gas chromatography for their alcohol content. Considerable variability in the alcoholic strength was found, even within the same class. Overall, the range...

journal_title：Journal of analytical toxicology

authors： Case GA,Distefano S,Logan BK

更新日期：2000-04-01 00:00:00

abstract：:The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic chec...

journal_title：Journal of analytical toxicology

authors： Röhrich J,Zörntlein S,Becker J,Urban R

更新日期：2010-04-01 00:00:00

abstract：:A forensic standard procedure is described that combines enzyme-linked immunoassay for screening and gas chromatography-mass spectrometry (GC-MS) for confirmation to detect drugs of abuse in a sample before used to detect opioids and cocaine. We used two equal aliquots of the same previously selected cannabinoid posit...

journal_title：Journal of analytical toxicology

authors： Tassoni G,Cippitelli M,Ottaviani G,Froldi R,Cingolani M

更新日期：2016-07-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:A gas chromatographic/mass spectrometric (GC/MS) method for the rapid quantitation of atropine (AT) in blood is presented. A 2.0-mL blood specimen containing deuterated N-methyl-atropine as the internal standard was alkaline-hydrolyzed to convert atropine to tropine. The tropine was extracted by organic solvent which ...

journal_title：Journal of analytical toxicology

authors： Saady JJ,Poklis A

更新日期：1989-09-01 00:00:00

abstract：:A clinical study was designed to determine if there was a predictable relationship between saliva and plasma codeine concentrations. Drug-free volunteers (n = 17) were administered a 30-mg dose of liquid codeine phosphate. Plasma and saliva specimens were collected at various times for 24 h after administration. Plasm...

journal_title：Journal of analytical toxicology

authors： O'Neal CL,Crouch DJ,Rollins DE,Fatah A,Cheever ML

更新日期：1999-10-01 00:00:00

abstract：:Quetiapine fumarate (Seroquel) is a dibenzothiazepine psychotropic agent that was introduced in 1997 for treating psychoses. Quetiapine is being found with increasing frequency in postmortem cases in Virginia. We report the postmortem results and histories of 20 quetiapine cases from the Office of the Chief Medical Ex...

journal_title：Journal of analytical toxicology

authors： Flammia DD,Valouch T,Venuti S

更新日期：2006-05-01 00:00:00

abstract：:This report describes a gas chromatographic procedure using a packed column and a flame ionization detector, which is suitable for the therapeutic monitoring of N-methylformamide (N-MF). N-MF is a polar compound that induces cancer cell maturation in vitro and exhibits antitumor activity with human tumors xenografted ...

journal_title：Journal of analytical toxicology

authors： Griffiths WC,Matook GM,Dexter DL,Crabtree GW,Spremulli EN,Calabresi P,Diamond I

更新日期：1983-03-01 00:00:00

abstract：:A 24-year-old man known to consume illegal drugs was found dead in his apartment. A reclosable plastic zipper bag containing several hundred milligrams of a brown powder was found close to the dead body and the first assumption of the investigators was death due to heroin intoxication. Therefore, a legal autopsy was o...

journal_title：Journal of analytical toxicology

authors： Dussy FE,Hangartner S,Hamberg C,Berchtold C,Scherer U,Schlotterbeck G,Wyler D,Briellmann TA

更新日期：2016-11-01 00:00:00

abstract：:A simple and sensitive method for determination of N,N-dimethyltryptamine (DMT) by gas chromatography (GC) with surface ionization detection (SID) is presented. Whole blood or urine, containing DMT and gramine (internal standard), was subjected to solid-phase extraction with a Sep-Pak C18 cartridge before analysis by ...

journal_title：Journal of analytical toxicology

authors： Ishii A,Seno H,Suzuki O,Hattori H,Kumazawa T

更新日期：1997-01-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) in whole blo...

journal_title：Journal of analytical toxicology

authors： Jamey C,Szwarc E,Tracqui A,Ludes B

更新日期：2008-06-01 00:00:00