Abstract:
:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, nonpolar stationary phase. The assay possesses linearity to 3.0 micrograms/mL, sensitivity to at least 0.25 microgram/mL, recovery averaging 96%, and between-run precision reflected by a CV of 5.6%. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of trazodone.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross REdoi
10.1093/jat/12.3.150subject
Has Abstractpub_date
1988-05-01 00:00:00pages
150-2issue
3eissn
0146-4760issn
1945-2403journal_volume
12pub_type
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