Abstract：
:Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins can readily decompose, and it is hard to find cyanohydrins in gastric contents and heart blood, the determination study in biological samples can be divided into two parts: the first is the determination of HCN by using a Prussian blue reaction and the HS-GC-MSD after derivatization by chloramine-T. The second is the determination of acetone or formaldehyde. In this part, headspace gas chromatography with flame ionization detector (HS-GC-FID) and solid phase microextraction (SPME)-gas chromatography with mass spectrometric detectors (GC-MSD) had been used. In this report, we reported two fatal intoxication cases of ACH and FCH; one person was killed by his wife by poisoning his food and the other was suicide by poison. Two real cases of ACH and FCH in human blood and gastric contents have been analyzed by using the above-mentioned method. The Prussian blue reaction was positive in the two cases. The peaks of acetone with retention times of 0.998 min appear in specimens of the deceased are consistent with the retention times of pure acetone. The peaks of formaldehyde with a retention time of 1.658 min appear in heart blood of the deceased, and the retention time of formaldehyde of the liquid is 1.674 min, which are consistent with the retention times of pure formaldehyde (1.673 min).
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Zheng S,Yuan X,Wang W,Liang C,Cao F,Zhang Rdoi
10.1093/jat/bkw023subject
Has Abstractpub_date
2016-06-01 00:00:00pages
388-95issue
5eissn
0146-4760issn
1945-2403pii
bkw023journal_volume
40pub_type
杂志文章abstract：:A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of let...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.4.248
更新日期：2011-05-01 00:00:00
abstract：:A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F...
journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/jat/28.6.422
更新日期：2004-09-01 00:00:00
abstract：:We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at p...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/21.2.127
更新日期：1997-03-01 00:00:00
abstract：:N,N-Diethyl-m-toluamide (DEET) is an effective component of several insect repellent products. A 19-year-old woman was admitted to the emergency department following ingestion of 15-25 mL 95% diethyltoluamide (Muscol). Serum and urine toxicology screening tests were negative except for detection of DEET. DEET was qual...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.3.197
更新日期：1995-05-01 00:00:00
abstract：:A rapid and simple liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of L-ephedrine, pseudoephedrine, and caffeine in male Fisher-344 rat plasma at nanogram-per-milliliter concentrations for use in support of toxicology studies. Only 25 μL of plasma is...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.6.341
更新日期：2011-07-01 00:00:00
abstract：:The aim of this study is to investigate the concentrations of ethyl glucuronide (EtG) in oral fluid and both EtG and ethyl sulfate (EtS) in blood and urine following intense use of mouthwash and ingestion of nonalcoholic wine, which are proven to contain 3 mg/L EtG, 1.5 mg/L EtS, and 0.2 g/L ethanol. Twelve subjects p...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/34.2.84
更新日期：2010-03-01 00:00:00
abstract：:Doxepin is a tricyclic antidepressant that is widely prescribed for the treatment of mild depression. In this study, hair samples collected from a patient receiving 25 mg of doxepin daily were analyzed. Doxepin was administered to the patient for 4 months (June 15 to October 15, 1996). Five hair samples were collected...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/22.6.531
更新日期：1998-10-01 00:00:00
abstract：:Ethanol is the most frequently identified compound in forensic toxicology. Although confirmation involving mass spectrometry is desirable, relatively few methods have been published to date. A novel technique utilizing a Dean's Switch to simultaneously quantitate and confirm ethyl alcohol by flame-ionization (FID) and...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.7.501
更新日期：2011-09-01 00:00:00
abstract：:Caffeine is the world's most widely consumed drug with its main source found in coffee. We evaluated the caffeine content of caffeinated and decaffeinated specialty coffee samples obtained from coffee shops. Caffeine was isolated from the coffee by liquid-liquid extraction and analyzed by gas chromatography with nitro...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/27.7.520
更新日期：2003-10-01 00:00:00
abstract：:A method is described for the simultaneous determination of the ratio of l- and d-enantiomers of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) in urine. The assay uses liquid-liquid extraction followed by deriv...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/23.6.518
更新日期：1999-10-01 00:00:00
abstract：:We present data from the analysis of the alcohol content of 391 beers and malt beverages available for sale in the State of Washington. The beverages were tested by gas chromatography for their alcohol content. Considerable variability in the alcoholic strength was found, even within the same class. Overall, the range...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.3.202
更新日期：2000-04-01 00:00:00
abstract：:A method for the simultaneous analysis of cocaine (COC), derivatized benzoylecgonine (BE), and derivatized ecgonine methyl ester (EME) has been developed. Blood or urine containing deuterated analogs of the three analytes is extracted by pouring over a Chem-Elut column and eluting with chloroform/isopropanol (9:1). Th...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/12.5.242
更新日期：1988-09-01 00:00:00
abstract：:Part I. Expert 4: The object of this study was to investigate the applicability of commercially available expert system shells to interpretation in forensic toxicology. Amitriptyline toxicology was selected as a pilot trial. Blood and tissue concentrations of amitriptyline and nortriptyline in fatal and nonfatal amitr...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/12.4.216
更新日期：1988-07-01 00:00:00
abstract：:A total of 183 random, whole-blood specimens was collected from healthy individuals within the State of Queensland (Australia), and the bromide concentration was determined by wavelength-dispersive X-ray fluorescence spectrometry (WDXRF). The intensity of the tube Compton scatter line was used to account for differenc...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/22.3.225
更新日期：1998-05-01 00:00:00
abstract：:An expert system applied as a screening test for amphetamine analogues found in recreational-drug exhibits (tablets or powders) is described. The knowledge base defining the reference Fourier transform infrared spectroscopic (FTIR) spectral patterns has been built according to criteria encompassing toxicological, phar...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/25.1.45
更新日期：2001-01-01 00:00:00
abstract：:During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/18.6.331
更新日期：1994-10-01 00:00:00
abstract：:Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and inco...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkw073
更新日期：2016-11-01 00:00:00
abstract：:Decomposed bone and plasma samples of rats exposed to amitriptyline (AMI) and citalopram (CIT) under different dosing patterns were analyzed. Wistar rats received one acute dose (120 mg AMI/kg and 40 mg CIT/kg; n = 5) or two doses (40 mg AMI/kg and 13 mg CIT/kg, n = 5) 40 min apart. After collection of perimortem bloo...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkt078
更新日期：2013-10-01 00:00:00
abstract：:Carfentanil is a mu (μ) opioid receptor agonist and is estimated to be ~10,000 times more potent than morphine in animal (non-human) models. It is not approved for human use and is only used to immobilize large exotic animals in veterinary medicine. In mid-2016, carfentanil emerged as a contaminant in street heroin in...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkx042
更新日期：2017-07-01 00:00:00
abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/30.4.232
更新日期：2006-05-01 00:00:00
abstract：:In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/25.3.179
更新日期：2001-04-01 00:00:00
abstract：:We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium. The FPIA is sensitiv...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/16.4.261
更新日期：1992-07-01 00:00:00
abstract：:The present study evaluates the suitability of headspace gas chromatography (GC) with a capillary column as a method for determining the ethanol content in different biological fluids. This procedure allows the use of headspace GC not only as a reference method but also in routine diagnostics and monitoring work. The ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.4.241
更新日期：1995-07-01 00:00:00
abstract：:A woman was alleged to have committed suicide by consuming a gasoline additive shortly before jumping from a second floor balcony within her home. She was found dead by police with a multitude of injuries, lying nude in a partially evaporated unknown residue that was later determined to be methanol. Samples collected ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/29.7.734
更新日期：2005-10-01 00:00:00
abstract：:Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter report of 2017 to have been chemically identified seven and five t...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bky035
更新日期：2018-11-01 00:00:00
abstract：:A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labelled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/14.3.189
更新日期：1990-05-01 00:00:00
abstract：:An original high-performance liquid chromatographic-mass spectrometric (HPLC-MS) procedure was developed for the determination of cyanide (CN) in whole blood. After the addition of K13C15N as internal standard, blood was placed in a microdiffusion device, the inner well of which was filled with a mixture of taurine (5...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/26.3.144
更新日期：2002-04-01 00:00:00
abstract：:A gas-chromatographic analysis of vinylidene chloride (1,1-dichloroethylene) is presented. Vinylidene chloride was sampled by adsorbing on activated carbon. It was desorbed with carbon disulfide. The desorption efficiency was 97.2 +/- 1.05 (mean +/- standard error). The analytical column was packed with 10% Apiezon L ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/4.5.266
更新日期：1980-09-01 00:00:00
abstract：:Gas chromatographic methods have been developed using a Supelco 1240-DA column for the determination of pentachlorophenol (PCP) in plasma and urine samples, and phenol in urine samples. These methods required no derivatization. Electron capture detection has been used for PCP determination, while flame ionization dete...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.6.297
更新日期：1982-11-01 00:00:00
abstract：:A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.3.153
更新日期：1982-05-01 00:00:00
