Abstract:
:A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium nitrate: 2 N ammonium hydroxide (28:1:1 v/v) as the mobile phase to separate the compounds and a fluorescence spectrophotometer for detection. Application of this method is demonstrated by the analysis of human plasma samples collected from a volunteer during a phenytoin-quinidine drug interaction study.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Pershing LK,Peat MA,Finkle BSdoi
10.1093/jat/6.3.153subject
Has Abstractpub_date
1982-05-01 00:00:00pages
153-6issue
3eissn
0146-4760issn
1945-2403journal_volume
6pub_type
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