Amphetamine as an artifact of methamphetamine during periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine: an improved procedure for accurate quantitation of amphetamines in urine.

Abstract:

:During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at pH 5.2 and above, this periodate-mediated transformation of methamphetamine to amphetamine was observed only at pH 9.1 and above. Therefore, to avoid this transformation, a pH of 6.2 was used for the oxidative degradation of phenylpropanolamines. The excess periodate was then reduced with thiosulfate or ascorbic acid prior to the extraction of methamphetamine using a basic pH.

journal_name

J Anal Toxicol

authors

Paul BD,Past MR,McKinley RM,Foreman JD,McWhorter LK,Snyder JJ

doi

10.1093/jat/18.6.331

subject

Has Abstract

pub_date

1994-10-01 00:00:00

pages

331-6

issue

6

eissn

0146-4760

issn

1945-2403

journal_volume

18

pub_type

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