Abstract:
:During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at pH 5.2 and above, this periodate-mediated transformation of methamphetamine to amphetamine was observed only at pH 9.1 and above. Therefore, to avoid this transformation, a pH of 6.2 was used for the oxidative degradation of phenylpropanolamines. The excess periodate was then reduced with thiosulfate or ascorbic acid prior to the extraction of methamphetamine using a basic pH.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Paul BD,Past MR,McKinley RM,Foreman JD,McWhorter LK,Snyder JJdoi
10.1093/jat/18.6.331subject
Has Abstractpub_date
1994-10-01 00:00:00pages
331-6issue
6eissn
0146-4760issn
1945-2403journal_volume
18pub_type
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