Determination of phenol and pentachlorophenol in plasma and urine samples by gas liquid chromatography.

abstract：:Comprehensive investigation is necessary for determining the cause of death in cases with positive drug screens. We investigated the case of a male who reportedly expired from an acute asthma attack. He had limited access to both therapeutic drugs and drugs of abuse because he was a state prisoner. His autopsy was rem...

journal_title：Journal of analytical toxicology

authors： Merigian K,Blaho K

更新日期：1995-10-01 00:00:00

abstract：:A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desmethyl-clomipramine and didesmethyl-clomipramine [DDCMI]), an...

journal_title：Journal of analytical toxicology

authors： Coudoré F,Hourcade F,Molinier-Manoukian C,Eschalier A,Lavarenne J

更新日期：1996-03-01 00:00:00

abstract：:Amoxapine, a tricyclic antidepressant, is metabolized to 8-hydroxyamoxapine and 7-hydroxyamoxapine. There are few reports on the metabolism of this drug and correlation of clinical symptoms in overdose patients. Five such patients admitted to the Emergency Unit of the University of Cincinnati Hospital were studied. Cl...

journal_title：Journal of analytical toxicology

authors： Tasset JJ,Pesce AJ

更新日期：1984-05-01 00:00:00

abstract：:The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...

journal_title：Journal of analytical toxicology

authors： Poklis A,Mackell MA

更新日期：1982-05-01 00:00:00

abstract：:Four kinds of volatile anesthetics (halothane, enflurane, isoflurane, and sevoflurane) that were dissolved in 3 microL of experimental plasma samples were examined by the pulse-heating gas chromatographic-mass spectrometric method, and this approach was found to be reliable for qualitative and quantitative analysis. T...

journal_title：Journal of analytical toxicology

authors： Saito K,Takayasu T,Nishigami J,Kondo T,Ohtsuji M,Lin Z,Ohshima T

更新日期：1995-03-01 00:00:00

abstract：:A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labelled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized...

journal_title：Journal of analytical toxicology

authors： Papac DI,Foltz RL

更新日期：1990-05-01 00:00:00

abstract：:In mothers who had no prenatal care and in their newborns, the presence of cocaine and benzoylecgonine (BE) was determined in urine, hair, and meconium. Samples of urine and hair were obtained from pregnant women who entered the hospital for delivery. Cocaine usage was assessed by a urinary enzyme-multiplied immunoass...

journal_title：Journal of analytical toxicology

authors： DiGregorio GJ,Ferko AP,Barbieri EJ,Ruch EK,Chawla H,Keohane D,Rosenstock R,Aldano A

更新日期：1994-09-01 00:00:00

abstract：:Prolintane is a sympathomimetic amine with pharmacologic properties similar to d-amphetamine. Side effects include insomnia, nervousness, and irritability. Overdoses of prolintane may cause hallucinations, psychosis, and death. The drug is commonly prescribed in Africa, Australia, and Europe but is not available in th...

journal_title：Journal of analytical toxicology

authors： Kyle PB,Daley WP

更新日期：2007-09-01 00:00:00

abstract：:Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable. Consequently, most laboratories employ liquid chromatography-tandem mass spectrometry (LC-MS-MS) screening, which can be complex ...

journal_title：Journal of analytical toxicology

authors： Neifeld JR,Regester LE,Holler JM,Vorce SP,Magluilo J Jr,Ramos G,Bosy TZ

更新日期：2016-06-01 00:00:00

abstract：:The aim of this study was to develop, optimize, and validate an analytical procedure to determine a group of eight amphetamines, amphetamine (AMP), ephedrine (EP), methcathinone (MTC), paramethoxyamphetamine (PMA), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methyle...

journal_title：Journal of analytical toxicology

authors： Stanaszek R,Piekoszewski W

更新日期：2004-03-01 00:00:00

abstract：:The measurement of cefoperazone concentrations in cerebral spinal fluid (CSF) is important to understanding the biodisposition and pharmacokinetic behavior of the drug. We have demonstrated that cefoperazone is unstable in methanol and at alkaline pH and these factors may affect the accurate quantitation of the drug i...

journal_title：Journal of analytical toxicology

authors： Kinniburgh DW,Jennison TA,Matsen JM

更新日期：1982-03-01 00:00:00

abstract：:Part I. Expert 4: The object of this study was to investigate the applicability of commercially available expert system shells to interpretation in forensic toxicology. Amitriptyline toxicology was selected as a pilot trial. Blood and tissue concentrations of amitriptyline and nortriptyline in fatal and nonfatal amitr...

journal_title：Journal of analytical toxicology

authors： Spiehler V,Spiehler E,Osselton MD

更新日期：1988-07-01 00:00:00

abstract：:Uncertainty is an inherent property of all measurements. The magnitude of this uncertainty will determine the number of meaningful digits that should be reported in a measurement result. Several statistical arguments are considered providing evidence that three digit truncated results are more appropriate than two sin...

journal_title：Journal of analytical toxicology

authors： Gullberg RG

更新日期：2015-06-01 00:00:00

abstract：:Given that external contamination must be considered in hair analysis, there is still a demand for reliable tools to differentiate between incorporation of drugs into the hair as a result of drug consumption and of the hair shaft by external contamination. With the aim of establishing alternative discrimination parame...

journal_title：Journal of analytical toxicology

authors： Scholz C,Quednow BB,Herdener M,Kraemer T,Baumgartner MR

更新日期：2019-08-23 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is an endogenous compound, but its presence in postmortem blood presents a challenge when interpreting elevated levels as GHB is misused as a recreational drug and is also produced postmortem. A total of 387 postmortem cases (273 male and 114 female) submitted to the toxicology laboratory b...

journal_title：Journal of analytical toxicology

authors： Korb AS,Cooper G

更新日期：2014-10-01 00:00:00

abstract：:The fraction of any surface-adsorbed contaminant available for absorption is considered the bioaccessible fraction. Applied previously to contaminants such as pesticides and heavy metals on surfaces such as soil, food and cosmetics, the term may also be used to describe the fraction of drug residue bound to work surfa...

journal_title：Journal of analytical toxicology

authors： Doran GS,Howitt JA

更新日期：2019-03-01 00:00:00

abstract：:This study describes a matrix-assisted laser-desorption-ionization (MALDI) mass spectrometry for rapid screening of 12 diuretics in spiked urine. C60 is used as the matrix for MALDI. Diuretics are directly analyzed by C60-MALDI without previous derivatization. The fact that most diuretic molecules contain sulfate grou...

journal_title：Journal of analytical toxicology

authors： Huang JP,Yuan CH,Shiea J,Chen YC

更新日期：1999-09-01 00:00:00

abstract：:A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium...

journal_title：Journal of analytical toxicology

authors： Pershing LK,Peat MA,Finkle BS

更新日期：1982-05-01 00:00:00

abstract：:Postmortem femoral blood concentrations of the antipsychotic drugs aripiprazole, chlorprothixene and its metabolite, and quetiapine were determined by LC-MS-MS in 25 cases for aripiprazole and 60 cases each for chlorprothixene and quetiapine. For cases where the cause of death was not related to the considered drugs, ...

journal_title：Journal of analytical toxicology

authors： Skov L,Johansen SS,Linnet K

更新日期：2015-01-01 00:00:00

abstract：:A method for determining the chemical warfare agent soman (GD) in rat plasma has been validated and applied to low-level inhalation exposure studies currently being conducted. This method utilizes a fluoride ion-based regeneration assay with isotope dilution followed by large volume injection gas chromatography with a...

journal_title：Journal of analytical toxicology

authors： Renner JA,Dabisch PA,Evans RA,McGuire JM,Totura AL,Jakubowski EM,Thomson SA

更新日期：2008-01-01 00:00:00

abstract：:In an effort to determine a practical, efficient, and economical alternative for the use of a radioimmunoassay (RIA) for the detection of lysergic acid diethylamide (LSD) in human urine, the performance of two photometric immunoassays (Dade Behring EMIT II and Microgenics CEDIA) and the Diagnostics Products Corp. (DPC...

journal_title：Journal of analytical toxicology

authors： Wiegand RF,Klette KL,Stout PR,Gehlhausen JM

更新日期：2002-10-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:The Substance Abuse and Mental Health Services Administration (SAMHSA) is currently evaluating hydrocodone (HC) for inclusion in the Mandatory Guidelines for Federal Workplace Drug Testing Programs. This study evaluated the time course of HC, norhydrocodone (NHC), dihydrocodeine (DHC) and hydromorphone (HM) in paired ...

journal_title：Journal of analytical toxicology

authors： Cone EJ,DePriest AZ,Heltsley R,Black DL,Mitchell JM,LoDico C,Flegel R

更新日期：2015-09-01 00:00:00

abstract：:The detection of 6-acetylmorphine (6-AM) in urine by immunoassay methods is challenging due to its short half-life and its similarity in structure to many commonly abused opiates that are often present at very high concentrations in urine. Current 6-AM homogeneous enzyme immunoassays use lyophilized reagents because o...

journal_title：Journal of analytical toxicology

authors： Wang G,Huynh K,Barhate R,Liu J,Tam P,Rodrigues W,Coulter C,Moore C,Soares J

更新日期：2015-11-01 00:00:00

abstract：:Analytical chemical procedures are described to determine residues of the drugs clofibrate and tibric acid in animal feed, wastewater, and human urine. Clofibrate was extracted from animal feed and human urine with hexane, whereas residues from wastewater were collected on a Sep-PakTM then eluted with methanol for ana...

journal_title：Journal of analytical toxicology

authors： Oller WL,Kendall DC,Bowman MC

更新日期：1982-07-01 00:00:00

abstract：:Six cases involving the antidepressant mirtazapine were analyzed in detail at the San Diego County Medical Examiner's Office from 2004 to 2005. Mirtazapine was initially detected and confirmed in each of these cases by a liquid-liquid gas chromatography (GC)-MS basic drug screen. Following another liquid-liquid basic ...

journal_title：Journal of analytical toxicology

authors： Kirkton C,McIntyre IM

更新日期：2006-11-01 00:00:00

abstract：:Decomposed bone and plasma samples of rats exposed to amitriptyline (AMI) and citalopram (CIT) under different dosing patterns were analyzed. Wistar rats received one acute dose (120 mg AMI/kg and 40 mg CIT/kg; n = 5) or two doses (40 mg AMI/kg and 13 mg CIT/kg, n = 5) 40 min apart. After collection of perimortem bloo...

journal_title：Journal of analytical toxicology

authors： Watterson JH,Cornthwaite HM

更新日期：2013-10-01 00:00:00

abstract：:Clonazepam, nitrazepam and flunitrazepam are frequently used benzodiazepines, both as prescribed medication and as drugs of abuse. Little is, however, known about how these drugs are excreted in oral fluid. It has been claimed that the parent drugs are more likely to be detected in oral fluid than the 7-amino metaboli...

journal_title：Journal of analytical toxicology

authors： Vindenes V,Strand DH,Koksæter P,Gjerde H

更新日期：2016-05-01 00:00:00

abstract：:A high-performance liquid chromatographic method has been developed for the simultaneous analysis of eight frequently used benzodiazepines and some of their metabolites in postmortem samples. The method includes a liquid-liquid extraction with n-hexane-ethyl acetate (70:30, v/v), gradient elution of a C8 reversed-phas...

journal_title：Journal of analytical toxicology

authors： Lambert WE,Meyer E,Xue-Ping Y,De Leenheer AP

更新日期：1995-01-01 00:00:00

abstract：:The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...

journal_title：Journal of analytical toxicology

authors： Sokoro A,Lehotay D,Eichhorst J,Treble R

更新日期：2007-07-01 00:00:00