Rapid screening for diuretic doping agents in urine by C60-assisted laser-desorption-ionization-time-of-flight mass spectrometry.

abstract：:Synthetic cannabinoids are a group of compounds that are structurally diverse and are commonly found in various herbal incense and potpourri blends, which are sold in convenience stores, smoke shops and over the Internet. During the past few years, multiple state and federal legislations have been enacted controlling ...

journal_title：Journal of analytical toxicology

authors： Shanks KG,Behonick GS,Dahn T,Terrell A

更新日期：2013-10-01 00:00:00

abstract：:Caffeine is the most widely consumed drug in the world with coffee representing a major source of intake. Despite widespread availability, various medical conditions necessitate caffeine-restricted diets. Patients on certain prescription medications are advised to discontinue caffeine intake. Such admonition has impli...

journal_title：Journal of analytical toxicology

authors： McCusker RR,Fuehrlein B,Goldberger BA,Gold MS,Cone EJ

更新日期：2006-10-01 00:00:00

abstract：:Gas chromatographic methods have been developed using a Supelco 1240-DA column for the determination of pentachlorophenol (PCP) in plasma and urine samples, and phenol in urine samples. These methods required no derivatization. Electron capture detection has been used for PCP determination, while flame ionization dete...

journal_title：Journal of analytical toxicology

authors： Rick DL,Licht CF,McCarty LP

更新日期：1982-11-01 00:00:00

abstract：:Caffeine is the world's most widely consumed drug with its main source found in coffee. We evaluated the caffeine content of caffeinated and decaffeinated specialty coffee samples obtained from coffee shops. Caffeine was isolated from the coffee by liquid-liquid extraction and analyzed by gas chromatography with nitro...

journal_title：Journal of analytical toxicology

authors： McCusker RR,Goldberger BA,Cone EJ

更新日期：2003-10-01 00:00:00

abstract：:A method utilizing microwave dissolution in a closed Teflon bomb followed by hydride generation atomic absorption spectrometry has been used for the routine analysis of arsenic in fish species from the coast of the province of Granada, Spain. The technique was evaluated for decomposing biological standard reference ma...

journal_title：Journal of analytical toxicology

authors： Navarro M,López H,López MC,Sánchez M

更新日期：1992-05-01 00:00:00

abstract：:The identification of benzodiazepines (BZD) in biological fluids can be a challenging process. The large number of various BZD in pharmaceutical distribution, with similar core structures, and individual metabolic profiles all contribute to a complicated and time-consuming analysis. The purpose of the current study wa...

journal_title：Journal of analytical toxicology

authors： DeRienz RT,Holler JM,Manos ME,Jemionek J,Past MR

更新日期：2008-07-01 00:00:00

abstract：:An analytical database, using high-performance liquid chromatography (HPLC) with diode array ultraviolet (UV) detection, of over 250 toxicologically relevant drugs has been extensively applied to both clinical and forensic toxicology. This general drug screening system, based on a mixed-phase (octadecyl/cyanopropyl) c...

journal_title：Journal of analytical toxicology

authors： Elliott SP,Hale KA

更新日期：1998-07-01 00:00:00

abstract：:Postmortem redistribution (PMR) constitutes a multifaceted process, which complicates the interpretation of drug concentrations by forensic toxicologists. The present study aimed to apply quantitative structure-activity relationship (QSAR) analysis for modeling PMR data of structurally related drugs, 10 benzodiazepine...

journal_title：Journal of analytical toxicology

authors： Giaginis C,Tsantili-Kakoulidou A,Theocharis S

更新日期：2014-06-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:A gas-chromatographic analysis of vinylidene chloride (1,1-dichloroethylene) is presented. Vinylidene chloride was sampled by adsorbing on activated carbon. It was desorbed with carbon disulfide. The desorption efficiency was 97.2 +/- 1.05 (mean +/- standard error). The analytical column was packed with 10% Apiezon L ...

journal_title：Journal of analytical toxicology

authors： Sidhu KS

更新日期：1980-09-01 00:00:00

abstract：:A protocol is described for the preparation and characterization of bovine blood lead (Pb) reference material (RM). Adult bovine animals are orally dosed with Pb as Pb(NO3)2, and blood is collected directly from the jugular vein into 5-mL evacuated, low-Pb glass tubes containing EDTA as anticoagulant. The blood is coo...

journal_title：Journal of analytical toxicology

authors： Cox DH,Duncan CE,Wyatt GP,Meadow JS,Robinson JB

更新日期：1989-07-01 00:00:00

abstract：:A liquid chromatographic method was developed for the analysis of indandione and 4-hydroxycoumarin anticoagulant rodenticides in blood serum and liver. The method enabled the measurement of serum and liver concentrations of eight anticoagulant rodenticides: brodifacoum, bromadiolone, chlorophacinone, coumafuryl, couma...

journal_title：Journal of analytical toxicology

authors： Chalermchaikit T,Felice LJ,Murphy MJ

更新日期：1993-01-01 00:00:00

abstract：:Fentanyl is a potent, short-acting narcotic analgesic widely used as a surgical anesthetic and for the control of pain when administered in the form of a transdermal patch. The success of the patch can be attributed to fentanyl's low molecular weight and its highly lipophilic nature, which enables it to be readily abs...

journal_title：Journal of analytical toxicology

authors： Anderson DT,Muto JJ

更新日期：2000-10-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of 25 common pharmaceuticals in whole blood. The selected pharmaceuticals represent the most frequently detected drugs in our forensic laboratory with basic properties such as analgesics, antid...

journal_title：Journal of analytical toxicology

authors： Nielsen MK,Johansen SS

更新日期：2012-09-01 00:00:00

abstract：:Endogenous γ-hydroxybutyric acid (GHB) concentrations in blood and urine are well documented, but there are very little data on natural levels in saliva, a biological matrix increasingly used for drug testing. We measured endogenous GHB concentrations in 120 unpaid volunteers who also provided anonymous epidemiologica...

journal_title：Journal of analytical toxicology

authors： De Paoli G,Walker KM,Pounder DJ

更新日期：2011-04-01 00:00:00

abstract：:We report the validation of a quantitative method for paraquat in plasma and urine using high-performance liquid chromatography (HPLC) with ultraviolet detection (260 nm). Furthermore, we illustrate the use of this method in the clinic (over five years), in conjunction with a qualitative urine paraquat screen. Urine o...

journal_title：Journal of analytical toxicology

authors： Taylor PJ,Salm P,Pillans PI

更新日期：2001-09-01 00:00:00

abstract：:Amoxapine, a tricyclic antidepressant, is metabolized to 8-hydroxyamoxapine and 7-hydroxyamoxapine. There are few reports on the metabolism of this drug and correlation of clinical symptoms in overdose patients. Five such patients admitted to the Emergency Unit of the University of Cincinnati Hospital were studied. Cl...

journal_title：Journal of analytical toxicology

authors： Tasset JJ,Pesce AJ

更新日期：1984-05-01 00:00:00

abstract：:Propane can be responsible for several types of lethal intoxication and explosions. Quantifying it would be very helpful to determine in some cases the cause of death. Some gas chromatography-mass spectrometry (GC-MS) methods of propane measurements do already exist. The main drawback of these GC-MS methods described ...

journal_title：Journal of analytical toxicology

authors： Smith F,Augsburger M,Varlet V

更新日期：2014-03-01 00:00:00

abstract：:Quetiapine fumarate (Seroquel) is a dibenzothiazepine psychotropic agent that was introduced in 1997 for treating psychoses. Quetiapine is being found with increasing frequency in postmortem cases in Virginia. We report the postmortem results and histories of 20 quetiapine cases from the Office of the Chief Medical Ex...

journal_title：Journal of analytical toxicology

authors： Flammia DD,Valouch T,Venuti S

更新日期：2006-05-01 00:00:00

abstract：:In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin ...

journal_title：Journal of analytical toxicology

authors： Høiseth G,Gottås A,Berg T,Arnestad M,Halvorsen PS,Bachs LC

更新日期：2017-06-01 00:00:00

abstract：:Dried blood spots (DBS) on filter paper have been used in human medicine since the 1960s, predominantly for screening in-borne metabolic disorders and more recently, for toxicology. Despite its 50-year existence, this technology has not been adopted by veterinarians for routine diagnoses and research. We have validate...

journal_title：Journal of analytical toxicology

authors： Lehner AF,Rumbeiha W,Shlosberg A,Stuart K,Johnson M,Domenech R,Langner H

更新日期：2013-09-01 00:00:00

abstract：:The nitrogen mustards bis(2-chloroethyl)ethylamine (HN1), bis(2-chloroethyl)methylamine (HN2), and tris(2-chloroethyl)amine (HN3) have the potential to be used as chemical terrorism agents because of their extreme vesicant properties. We modified a previously reported method to incorporate automated solid-phase extrac...

journal_title：Journal of analytical toxicology

authors： Lemire SW,Barr JR,Ashley DL,Olson CT,Hayes TL

更新日期：2004-07-01 00:00:00

abstract：:A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...

journal_title：Journal of analytical toxicology

authors： Pinto M,Eusébio E,Monteiro C

更新日期：2020-10-08 00:00:00

abstract：:A gas chromatographic-chemical ionization mass spectrometric (GC-CIMS) method is described for the determination of cocaine, benzoylecgonine, and norcocaine. The procedure uses stable isotopes as internal standards and a mixture of methane-ammonia as chemical ionization reagent gas. Run-to-run and within-run coefficie...

journal_title：Journal of analytical toxicology

authors： Chinn DM,Crouch DJ,Peat MA,Finkle BS,Jennison TA

更新日期：1980-01-01 00:00:00

abstract：:A case of lethal overdose by heroin ingestion is presented. The concentrations of drugs were measured several hours after death. Heroin, 06-monoacetylmorphine, and morphine were identified and quantitated in blood, urine, and gastrointestinal contents by gas chromatography-mass spectrometry and high-performance liquid...

journal_title：Journal of analytical toxicology

authors： Rop PP,Fornaris M,Salmon T,Burle J,Bresson M

更新日期：1997-05-01 00:00:00

abstract：:A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F...

journal_title：Journal of analytical toxicology

authors： Poklis A,Backer R

更新日期：2004-09-01 00:00:00

abstract：:Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control...

journal_title：Journal of analytical toxicology

authors： Desharnais B,Camirand-Lemyre F,Mireault P,Skinner CD

更新日期：2017-05-01 00:00:00

abstract：:The purpose of this study was to develop and validate a gas chromatography-mass spectrometry method to detect drugs of abuse in a single sample of tooth. Pulverized samples of dental materials were subjected to acid hydrolysis to detect opiates, cocaine and their metabolites. The residual dental materials from these a...

journal_title：Journal of analytical toxicology

authors： Ottaviani G,Cameriere R,Cippitelli M,Froldi R,Tassoni G,Zampi M,Cingolani M

更新日期：2017-01-01 00:00:00

abstract：:Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 micrograms/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 m...

journal_title：Journal of analytical toxicology

authors： Lehmann T,Sager F,Brenneisen R

更新日期：1997-09-01 00:00:00

abstract：:Suvorexant (Belsomra®) is a novel dual orexin receptor antagonist used for the treatment of insomnia. The prevalence of suvorexant in forensic samples is relatively unknown, which demonstrates the need for robust analytical assays for the detection of this sedative hypnotic in forensic toxicology laboratories. In this...

journal_title：Journal of analytical toxicology

authors： Skillman B,Kerrigan S

更新日期：2020-04-30 00:00:00