One-step immunoassay for acetaminophen and salicylate in serum, plasma, and whole blood.

abstract：:Two cases of overdose due to ingestion of trazodone are described. In one case, blood collected several hours following ingestion of an estimated 4 or more grams contained a trazodone concentration of 25.7 mg/L. Recovery was uneventful. The second case did not survive and death was attributed to the ingestion of multi...

journal_title：Journal of analytical toxicology

authors： Root I,Ohlson GB

更新日期：1984-03-01 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent that causes painful blisters and chemically modifies endogenous biomacromolecules by alkylation to hydroxyethylthioethyl (HETE) adducts representing valuable long-term markers for post-exposure analysis. The albumin adduct formed in human plasma in vitro (HETE bound to t...

journal_title：Journal of analytical toxicology

authors： Gandor F,Gawlik M,Thiermann H,John H

更新日期：2015-05-01 00:00:00

abstract：:Hydrocodone in combination with acetaminophen is commonly used to control moderate pain and is metabolized by cytochrome P4502D6 to form the active metabolite, hydromorphone. The purpose of this study was to determine the metabolic relationship and variability between hydrocodone and its conversion to hydromorphone us...

journal_title：Journal of analytical toxicology

authors： Barakat NH,Atayee RS,Best BM,Pesce AJ

更新日期：2012-05-01 00:00:00

abstract：:A rapid, reproducible and sensitive reversed phase liquid chromatography-mass spectrometry method was developed and validated for the identification and semi-quantitative confirmation of stimulants in urine. The method is capable of separating compounds such as cocaine and metabolites, amphetamines, substituted cathin...

journal_title：Journal of analytical toxicology

authors： O'Byrne PM,Kavanagh PV,McNamara SM,Stokes SM

更新日期：2013-03-01 00:00:00

abstract：:With the increased availability of nitrite-containing commercial products that are used for the adulteration of urine samples in the workplace, it is necessary for laboratories to be able to detect and confirm the presence of nitrite in these samples. We have developed a method to confirm the presence of nitrite in ur...

journal_title：Journal of analytical toxicology

authors： Singh J,Elberling JA,Hemphill DG,Holmstrom J

更新日期：1999-05-01 00:00:00

abstract：:Ethylene glycol (EG), a relatively infrequent cause of fatal intoxication, presents an analytical challenge for forensic confirmation in postmortem toxicology. We report EG and glycolic acid (GA) quantification in postmortem blood by gas chromatography coupled with ion trap mass spectrometry (GC-MS) analysis using a m...

journal_title：Journal of analytical toxicology

authors： Rosano TG,Swift TA,Kranick CJ,Sikirica M

更新日期：2009-10-01 00:00:00

abstract：:A microextraction by packed sorbent (MEPS) procedure for rapid concentration of methadone and its primary metabolite (EDDP) in hair samples was developed. The miniaturized approach coupled to gas chromatography with tandem mass spectrometry (GC-MS-MS) was successfully validated. Hair samples (50 mg) were incubated wit...

journal_title：Journal of analytical toxicology

authors： Rosado T,Gallardo E,Vieira DN,Barroso M

更新日期：2020-12-12 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid extraction, followed by solid-phase extraction, and separation on an HP5 Trace column. Ionization mode was electronic ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Dubois N,Cucchiaro S,Plomteux G

更新日期：2003-03-01 00:00:00

abstract：:Hypertension is one of the most important modifiable risk factor causing cardiovascular disease. Unfortunately, non-adherence to antihypertensive medications is frequently observed in hypertensive patients and can lead to an increase in morbidity and mortality. Until recently, there was no robust clinical method to ob...

journal_title：Journal of analytical toxicology

authors： Burns AD,Alghamadi R,Iqbal A,Davies T,Lane D,Patel P,Gupta P

更新日期：2020-12-10 00:00:00

abstract：:The effect of long-term room temperature storage on the stability of ethanol in whole blood specimens was investigated. One hundred and seventeen preserved whole blood case samples (110 of 117 with two tubes of blood in each case) were used for this study. One tube from each case was initially tested for blood alcohol...

journal_title：Journal of analytical toxicology

authors： Tiscione NB,Vacha RE,Alford I,Yeatman DT,Shan X

更新日期：2015-07-01 00:00:00

abstract：:Quantitative analysis of Δ9-tetrahydrocannabinol (Δ9-THC) in oral fluid has gained increasing interest in clinical and forensic toxicology laboratories. New medicinal and/or recreational cannabinoid products require laboratories to distinguish different patterns of cannabinoid use. This study validated a high-performa...

journal_title：Journal of analytical toxicology

authors： Lin L,Amaratunga P,Reed J,Huang P,Lemberg BL,Lemberg D

更新日期：2020-12-03 00:00:00

abstract：:Methyl methacrylate polymer (PolyMMA) is widely used as the composite resin for the dental plate. During the fabrication process of PolyMMA for the polymerization reaction, benzoylperoxide (BPO) and N,N-dimethyl p-toluidine (DMPT) are added as the initiator and the stimulator, respectively. Because these compounds exh...

journal_title：Journal of analytical toxicology

authors： Shintani H,Tsuchiya T,Hata Y,Nakamura A

更新日期：1993-03-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:We describe herewith the case of a patient presenting to the emergency department for worsening ear-nose-throat symptoms. As chemsex was evocated by the family, patient's serum was submitted to a new psychoactive substances screening. After a simple liquid liquid extraction, serum was injected on a high-resolution mas...

journal_title：Journal of analytical toxicology

authors： Deville M,Dubois N,Charlier C

更新日期：2020-11-04 00:00:00

abstract：:In recent years, several synthetic cannabinoid compounds have become popular recreational drugs of abuse because of their psychoactive properties. This paper presents toxicological findings of synthetic cannabinoids in whole blood from some cases of severe intoxication including quantitative data from recreational use...

journal_title：Journal of analytical toxicology

authors： Kronstrand R,Roman M,Andersson M,Eklund A

更新日期：2013-10-01 00:00:00

abstract：:A new method was developed to apply the advantages of automated gas chromatographic headspace analysis to delayed measurement of alcohol in whole breath (W-B). End-expiratory breath and vapor-alcohol samples were collected in sealed, heated 22-mL glass vials, stored for 0-15 days, and thereafter analyzed for alcohol b...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Essary NA

更新日期：1982-09-01 00:00:00

abstract：:An online automatic sample cleanup system was developed for use with electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid (S-PMA) in human urine. The sample clean-up system was constructed with an autosampling device, a r...

journal_title：Journal of analytical toxicology

authors： Liao PC,Li CM,Lin LC,Hung CW,Shih TS

更新日期：2002-05-01 00:00:00

abstract：:A modification of the Syva EMIT-tox Serum Barbiturate Assay was developed to provide a rapid and practical method for quantitating serum barbiturates. Standard curves for eight selected barbiturates were run using specific sets of standards for each. Correlation coefficients, slopes, and y-intercepts for the curves of...

journal_title：Journal of analytical toxicology

authors： Watson AT,Manno JE,Manno BR

更新日期：1983-11-01 00:00:00

abstract：:A simple and efficient method, based on the adsorption properties of octadecasilane bonded silica, is described for the rapid extraction of acidic drugs from whole post mortem blood. The blood was diluted, passed through an extraction column containing the bonded silica and the absorbed drugs were eluted with methanol...

journal_title：Journal of analytical toxicology

authors： Ford B,Vine J,Watson TR

更新日期：1983-05-01 00:00:00

abstract：:A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous quantification of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. Drugs were extracted from all matrices by liquid-liquid extraction with 1-chlorobutane. Chromatography was achieved using a...

journal_title：Journal of analytical toxicology

authors： Laloup M,Ramirez Fernandez Mdel M,De Boeck G,Wood M,Maes V,Samyn N

更新日期：2005-10-01 00:00:00

abstract：:The stability of nortriptyline in aqueous solutions containing various concentrations of formaldehyde was investigated. Amitriptyline, as a reaction product, was determined by gas chromatography/mass spectrometry (GC/MS) in these experiments. Factors that may contribute to this phenomenon, including pH, formaldehyde c...

journal_title：Journal of analytical toxicology

authors： Dettling RJ,Briglia EJ,Dal Cortivo LA,Bidanset JH

更新日期：1990-09-01 00:00:00

abstract：INTRODUCTION:We encountered unexpected false positive urine results in three patients for amphetamine-type substances by immunoassay, measured as part of community drug prevention programmes. Kavain was identified in all three urine samples by gas chromatography mass spectrometry (GC-MS). No other potential cross-react...

journal_title：Journal of analytical toxicology

authors： Madhavaram H,Patel T,Kyle C

更新日期：2020-12-16 00:00:00

abstract：:A simple isocratic HPLC procedure for the analysis of cocaine in plasma, with or without an internal standard, is described for the first time. Basified plasma was extracted in ether, re-extracted in acetic acid, which was subsequently basified prior to the final extraction in n-hexane. The hexane extract was evaporat...

journal_title：Journal of analytical toxicology

authors： Masoud AN,Krupski DM

更新日期：1980-11-01 00:00:00

abstract：:Hair samples from 20 documented heroin users contained 6-acetylmorphine, a unique metabolite of heroin, in all samples. Heroin was identified in smaller amounts in seven of these samples. The identity of 6-acetylmorphine and heroin was established by comparison of full scan spectra of extracts to standard reference ma...

journal_title：Journal of analytical toxicology

authors： Goldberger BA,Caplan YH,Maguire T,Cone EJ

更新日期：1991-09-01 00:00:00

abstract：:Comprehensive investigation is necessary for determining the cause of death in cases with positive drug screens. We investigated the case of a male who reportedly expired from an acute asthma attack. He had limited access to both therapeutic drugs and drugs of abuse because he was a state prisoner. His autopsy was rem...

journal_title：Journal of analytical toxicology

authors： Merigian K,Blaho K

更新日期：1995-10-01 00:00:00

abstract：:An expert system applied as a screening test for amphetamine analogues found in recreational-drug exhibits (tablets or powders) is described. The knowledge base defining the reference Fourier transform infrared spectroscopic (FTIR) spectral patterns has been built according to criteria encompassing toxicological, phar...

journal_title：Journal of analytical toxicology

authors： Praisler M,Dirinck I,Van Bocxlaer JF,De Leenheer AP,Massart DL

更新日期：2001-01-01 00:00:00

abstract：:The selectivity of analytical methods used to determine ethanol in body fluids has always been an important concern in connection with chemical testing for intoxication. Allegations of false high breath-alcohol readings obtained because of the presence of volatile organic compounds (VOCs) other than ethanol is a well-...

journal_title：Journal of analytical toxicology

authors： Jones AW

更新日期：1996-11-01 00:00:00

abstract：:The U.S. Drug Enforcement Administration has several different systems for collecting information on drugs of abuse. One is an early warning system, which collects information to provide scientific data and interpretation on drug abuse. Another is the collection of data from evidence submitted to DEA laboratories. Thi...

journal_title：Journal of analytical toxicology

authors： Frank RS

更新日期：1987-11-01 00:00:00

abstract：:The National Institute of Standards and Technology (formerly the National Bureau of Standards), in cooperation with the College of American Pathologists (CAP), has certified the concentrations of phencyclidine (PCP) in two new reference materials (RMs). One of these materials is Standard Reference Material (SRM) 1511,...

journal_title：Journal of analytical toxicology

authors： Tai SS,Christensen RG,Coakley K,Ellerbe P,Long T,Welch MJ

更新日期：1996-01-01 00:00:00