Abstract:
:The stability of nortriptyline in aqueous solutions containing various concentrations of formaldehyde was investigated. Amitriptyline, as a reaction product, was determined by gas chromatography/mass spectrometry (GC/MS) in these experiments. Factors that may contribute to this phenomenon, including pH, formaldehyde concentration, and incubation time were evaluated. At 40% (v/v) formaldehyde concentration and pH 4, there was a 68% decrease in nortriptyline concentration along with a concomitant formation of amitriptyline after 24 h. The N-methylated product was responsible for 48% of the total tricyclic drug present. The data also clearly indicate that the formation of amitriptyline is favored at elevated pH.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Dettling RJ,Briglia EJ,Dal Cortivo LA,Bidanset JHdoi
10.1093/jat/14.5.325subject
Has Abstractpub_date
1990-09-01 00:00:00pages
325-6issue
5eissn
0146-4760issn
1945-2403journal_volume
14pub_type
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