Abstract:
:Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the human CNS. However, in so doing, a new set of problems and concerns surrounding the technique must be addressed because of the unique transduction mechanisms (both physiological and biophysical) that exist to produce the fMRI signal from the underlying neuronal activity. Experimental design and control issues become paramount in performing fMRI pharmacological protocols and in signal interpretation. With these caveats, the use of pharmacological agents with fMRI is likely to greatly increase in the near term as new questions about both brain physiology and neuropharmacological mechanisms become addressable for the first time. Examples are given using nicotine and cocaine as a prototypical agents.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Stein EAdoi
10.1093/jat/25.5.419keywords:
subject
Has Abstractpub_date
2001-07-01 00:00:00pages
419-24issue
5eissn
0146-4760issn
1945-2403journal_volume
25pub_type
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