Abstract:
:A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. The ATS-related drugs analyzed in this study include ephedrine, pseudoephedrine, amphetamine, methamphetamine, MDMA (3,4-Methylenedioxymethamphetamine), MDA (3,4-Methylenedioxyamphetamine), MDEA (3,4-Methylenedioxy-N-ethylamphetamine) and phentermine. The relative standard deviation for inter and intraday was less than 15% while recoveries ranged from 80% to 120% for all three matrices, i.e., whole blood, urine and dried blood stain. All compounds gave library matching percentage of more than 85% based on the purity. This method was proven to be simple and robust, and provide high confident results complemented with library matching confirmation.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Zubaidi FA,Choo YM,Tan GH,Hamid HA,Choy YKdoi
10.1093/jat/bkz017subject
Has Abstractpub_date
2019-08-23 00:00:00pages
528-535issue
7eissn
0146-4760issn
1945-2403pii
5505412journal_volume
43pub_type
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