当前位置： SCI文献检索 > JOURNAL OF ANALYTICAL TOXICOLOGY期刊下所有文献 > Early-phase postmortem redistribution of the enantiomers of citalopram and its demethylated metabolites in rats.

Early-phase postmortem redistribution of the enantiomers of citalopram and its demethylated metabolites in rats.

Abstract：

:The aim of this study was to investigate the early-phase postmortem redistribution of the enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) in a rat model. Furthermore, we wanted to examine the role of the lungs as a reservoir of postmortem drug release and to investigate the influence of storage temperature (21 degrees C vs. 4 degrees C) on postmortem changes. Rats were administered a single CIT dose of 100 mg/kg (s.c.), and heart blood and lung samples were collected antemortem and 15 min postmortem for enantioselective high-performance liquid chromatographic analysis. About three times higher blood drug and metabolite levels were observed in the postmortem rats than in the antemortem rats (p < 0.0001). Refrigeration at 4 degrees C did not prevent, but significantly reduced, the postmortem increase in heart blood CIT levels as compared to the concentrations in the rats stored at 21 degrees C (p < 0.05). The lung drug concentrations were lower postmortem than antemortem (p < 0.05). The enantiomeric (S/R) concentration ratios of CIT and metabolites in blood and lungs were of similar magnitude before and after death. The parent-drug-to-metabolite ratios for CIT/DCIT were unchanged after death. In conclusion, this study shows that heart blood CIT and metabolite levels increase rapidly after death. Further, a fall in postmortem CIT concentrations in the lungs was observed, indicating that the lungs seemed to represent one major source of drug release during early-phase postmortem redistribution.

journal_name

J Anal Toxicol

journal_title

Journal of analytical toxicology

authors

Kugelberg FC,Kingbäck M,Carlsson B,Druid H

doi

10.1093/jat/29.4.223

keywords:

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

223-8

issue

4

eissn

0146-4760

issn

1945-2403

journal_volume

29

pub_type

杂志文章

相关文献

JOURNAL OF ANALYTICAL TOXICOLOGY文献大全
  • Bone surface and whole bone as biomarkers for acute fluoride exposure.

    abstract：:This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/29.8.810

    authors： Buzalaf MA,Caroselli EE,de Carvalho JG,de Oliveira RC,da Silva Cardoso VE,Whitford GM

    更新日期：2005-11-01 00:00:00

  • Suicide due to cyclizine overdose.

    abstract：:Cyclizine is an antihistamine with sedative effect used to treat motion sickness. A few studies have reported on cyclizine abuse among teenagers, and cyclizine abuse has been reported among opioid dependants receiving methadone, with the combination having been reported to produce strong psychoactive effects. Few repo...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkt100

    authors： Arnestad M,Eldor KB,Stray-Pedersen A,Bachs L,Karinen R

    更新日期：2014-03-01 00:00:00

  • Simultaneous determination of eight anticoagulant rodenticides in blood serum and liver.

    abstract：:A liquid chromatographic method was developed for the analysis of indandione and 4-hydroxycoumarin anticoagulant rodenticides in blood serum and liver. The method enabled the measurement of serum and liver concentrations of eight anticoagulant rodenticides: brodifacoum, bromadiolone, chlorophacinone, coumafuryl, couma...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/17.1.56

    authors： Chalermchaikit T,Felice LJ,Murphy MJ

    更新日期：1993-01-01 00:00:00

  • Gas chromatographic-mass spectrometric determination of british anti-lewisite in plasma.

    abstract：:British anti-Lewisite (BAL) (2,3-dimercapto-1-propanol) is a potential therapeutic compound when used against the effects of cutaneous sulfur mustard, and a method for its determination in plasma has been developed. BAL and the internal standard (IS) ethane dithiol were isolated from plasma samples through solid-phase...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/28.5.384

    authors： Byers CE,Holloway ER,Korte WD,Smith JR,Clarkson ED,Platoff GE,Capacio BR

    更新日期：2004-07-01 00:00:00

  • Screening method for the detection of methamphetamine in hair using fluorescence polarization immunoassay.

    abstract：:A hair screening method has been developed for the detection of methamphetamine using an immunoassay analyzer (AxSYM) with a fluorescence polarization immunoassay (FPIA) technique. The method consisted of washing, cutting and digesting a hair sample (5 mg) with an enzymatic digestion solution. The digested hair sample...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkt011

    authors： Cheong JC,Suh S,Ko BJ,Lee JI,Kim JY,Suh YJ,In MK

    更新日期：2013-05-01 00:00:00

  • Metabolism of nine benzidine-congener-based azo dyes in rats based on gas chromatographic assays of the urine for potentially carcinogenic metabolites.

    abstract：:Metabolism experiments were conducted with rats dosed with nine azo dyes based on dimethyl-, dimethoxy-, or dichlorobenzidine to determine whether the free amine congeners, their monoacetyl or diacetyl metabolites, or alkaline hydrolyzable conjugates were excreted in the urine. After preliminary tests of the dyes, 2-m...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/7.1.55

    authors： Bowman MC,Nony CR,Billedeau SM,Martin JL,Thompson HC Jr,Lowry LK

    更新日期：1983-01-01 00:00:00

  • A Novel Liquid Chromatography Tandem Mass Spectrometry Technique using Multi-Period-Multi-Experiment of MRM-EPI-MRM3 with Library Matching for Simultaneous Determination of Amphetamine Type Stimulants Related Drugs in Whole Blood, Urine and Dried Blood St

    abstract：:A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. Th...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkz017

    authors： Zubaidi FA,Choo YM,Tan GH,Hamid HA,Choy YK

    更新日期：2019-08-23 00:00:00

  • The identification of a chlorinated MDMA.

    abstract：:The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA) is increasing throughout the world. They have become popular drugs at all night techno dance parties, and their detection is an important issue. The objective of the presented study was to identify an unknown compound detected by t...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/29.5.353

    authors： Maresova V,Hampl J,Chundela Z,Zrcek F,Polasek M,Chadt J

    更新日期：2005-07-01 00:00:00

  • Stability and Degradation Pathways of Different Psychoactive Drugs in Neat and in Buffered Oral Fluid.

    abstract：:Sampling and drug stability in oral fluid (OF) are crucial factors when interpreting forensic toxicological analysis, mainly because samples may not be analyzed immediately after collection, potentially altering drug concentrations. Therefore, the stability of some common drugs of abuse (morphine, codeine, 6-monoacety...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkz114

    authors： Marchei E,Malaca S,Graziano S,Gottardi M,Pichini S,Busardò FP

    更新日期：2020-07-31 00:00:00

  • Sensitivity of an opiate immunoassay for detecting hydrocodone and hydromorphone in urine from a clinical population: analysis of subthreshold results.

    abstract：:Urine drug testing (UDT) is an emerging standard of care in the evaluation and treatment of chronic non-cancer pain patients with opioid analgesics. UDT may be used both to verify adherence with the opioid analgesic regimen and to monitor abstinence from non-prescribed or illicit controlled substances. In the former s...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bku109

    authors： Bertholf RL,Johannsen LM,Reisfield GM

    更新日期：2015-01-01 00:00:00

  • An online automatic sample cleanup system for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid in human urine by electrospray ionization tandem mass spectrometry.

    abstract：:An online automatic sample cleanup system was developed for use with electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid (S-PMA) in human urine. The sample clean-up system was constructed with an autosampling device, a r...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/26.4.205

    authors： Liao PC,Li CM,Lin LC,Hung CW,Shih TS

    更新日期：2002-05-01 00:00:00

  • Stability of benzodiazepines and cocaine in blood spots stored on filter paper.

    abstract：:Previous studies have shown that drug concentrations in blood can change during storage, especially at room temperature, but even labile drugs such as cocaine may be stable in dried blood spots (DBS). A new method has been developed for the analysis of hydrolytically labile drugs in blood spots on filter paper in orde...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/32.7.511

    authors： Alfazil AA,Anderson RA

    更新日期：2008-09-01 00:00:00

  • Determination of phenanthrene and hydroxyphenanthrenes in various biological matrices at trace levels using gas chromatography-mass spectrometry.

    abstract：:A fast and efficient multiresidue extraction-purification procedure was developed for low levels (ppb range) of phenanthrene and hydroxyphenanthrene in biological matrices, in order to quantify phenanthrene and metabolites in blood, milk, urine, and biological tissues of lactating goats. Detection and identification o...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/29.3.175

    authors： Grova N,Monteau F,Le Bizec B,Feidt C,Andre F,Rychen G

    更新日期：2005-04-01 00:00:00

  • Endogenous concentrations of GHB in postmortem blood from deaths unrelated to GHB use.

    abstract：:Gamma-hydroxybutyrate (GHB) is an endogenous compound, but its presence in postmortem blood presents a challenge when interpreting elevated levels as GHB is misused as a recreational drug and is also produced postmortem. A total of 387 postmortem cases (273 male and 114 female) submitted to the toxicology laboratory b...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bku088

    authors： Korb AS,Cooper G

    更新日期：2014-10-01 00:00:00

  • Excretion of cannabinoids in urine after ingestion of cannabis seed oil.

    abstract：:Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 micrograms/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 m...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/21.5.373

    authors： Lehmann T,Sager F,Brenneisen R

    更新日期：1997-09-01 00:00:00

  • Sudden death following accidental ingestion of chlormequat.

    abstract：:A 59-year-old white male accidentally ingested a mouthful of a plant growth chemical, Cycocel, containing 11.8% of the active ingredient (2-chloroethyl)trimethylammonium chloride (chlormequat). He was seen by a family physician and then transferred to a hospital where he died as a result of ventricular fibrillation, w...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/14.4.257

    authors： Winek CL,Wahba WW,Edelstein JM

    更新日期：1990-07-01 00:00:00

  • Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry.

    abstract：:A previously reported procedure for quantification of LSD in urine was modified to permit measurement of the drug in plasma. After addition of deuterium-labelled LSD, the plasma is extracted and the extract is treated with trifluoroacetylimidazole to convert the LSD to its N-trifluoroacetyl derivative. The derivatized...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/14.3.189

    authors： Papac DI,Foltz RL

    更新日期：1990-05-01 00:00:00

  • Evaluation of the Abbott ADx Amphetamine/Methamphetamine II abused drug assay: comparison to TDx, EMIT, and GC/MS methods.

    abstract：:Although the legitimate clinical use of amphetamine and amphetamine congeners is declining, the illicit use of these drugs remains high. There is a need for a rapid and conclusive method for detecting these compounds in routine urine drug testing, drug screening in drug rehabilitation centers, and as an aid in the dia...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/15.6.323

    authors： Przekop MA,Manno JE,Kunsman GW,Cockerham KR,Manno BR

    更新日期：1991-11-01 00:00:00

  • Ethyl glucuronide, ethyl sulfate, and ethanol in urine after intensive exposure to high ethanol content mouthwash.

    abstract：:To determine the degree of ethanol absorption and the resultant formation and urinary excretion of its conjugated metabolites following intensive use of high ethanol content mouthwash, 10 subjects gargled with Listerine(®) antiseptic 4 times daily for 3¼ days. First morning void urine specimens were collected on each ...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/anatox/35.5.264

    authors： Reisfield GM,Goldberger BA,Pesce AJ,Crews BO,Wilson GR,Teitelbaum SA,Bertholf RL

    更新日期：2011-06-01 00:00:00

  • Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine.

    abstract：:The aim of this study is to investigate the concentrations of ethyl glucuronide (EtG) in oral fluid and both EtG and ethyl sulfate (EtS) in blood and urine following intense use of mouthwash and ingestion of nonalcoholic wine, which are proven to contain 3 mg/L EtG, 1.5 mg/L EtS, and 0.2 g/L ethanol. Twelve subjects p...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/34.2.84

    authors： Høiseth G,Yttredal B,Karinen R,Gjerde H,Christophersen A

    更新日期：2010-03-01 00:00:00

  • Urinary Kinetics of Heroin Metabolites in Pigs Shortly After Intake.

    abstract：:In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin ...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkx017

    authors： Høiseth G,Gottås A,Berg T,Arnestad M,Halvorsen PS,Bachs LC

    更新日期：2017-06-01 00:00:00

  • Background levels of bromide in human blood.

    abstract：:A total of 183 random, whole-blood specimens was collected from healthy individuals within the State of Queensland (Australia), and the bromide concentration was determined by wavelength-dispersive X-ray fluorescence spectrometry (WDXRF). The intensity of the tube Compton scatter line was used to account for differenc...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/22.3.225

    authors： Olszowy HA,Rossiter J,Hegarty J,Geoghegan P

    更新日期：1998-05-01 00:00:00

  • Benzodiazepine analysis by negative chemical ionization gas chromatography/mass spectrometry.

    abstract：:The application of gas chromatography/mass spectrometry (GC/MS) for the simultaneous quantitation of seven commonly encountered urinary benzodiazepine metabolites is described. After comparison of the signal-to-noise ratios of high mass ions of benzodiazepines using electron impact (EI), positive chemical ionization (...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/17.6.342

    authors： Fitzgerald RL,Rexin DA,Herold DA

    更新日期：1993-10-01 00:00:00

  • Validation of a Fully Automated Immunoaffinity Workflow for the Detection and Quantification of Insulin Analogs by LC-MS-MS in Postmortem Vitreous Humor.

    abstract：:The analysis of biological specimens collected at autopsy for the presence of exogenous insulin(s) is of special interest in select death investigations as they may be suspected in the cause of a death. Technical challenges include the limited stability of insulin, and the forensic requirement of differentiating endog...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkz014

    authors： Legg KM,Labay LM,Aiken SS,Logan BK

    更新日期：2019-08-23 00:00:00

  • Pentazocine and tripelennamine (T's and Blues) abuse: toxicological findings in 39 cases.

    abstract：:The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/6.3.109

    authors： Poklis A,Mackell MA

    更新日期：1982-05-01 00:00:00

  • Long-Term Detection In Hair Of Zolpidem, Oxazepam And Flunitrazepam In A Case Of Drug-Facilitated Sexual Assault.

    abstract：:Drug-facilitated sexual assault (DFSA) cases are pretty common in forensic toxicology. In this case report, a 56-year-old female tourist claimed to have been sexually assaulted by five men after having had a drug-spiked alcoholic drink. Urine samples were collected at 38, 44, and 45 hours after the alleged rape. After...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bkaa174

    authors： Carfora A,Campobasso CP,Cassandro P,Petrella R,Borriello R

    更新日期：2020-11-12 00:00:00

  • Comparison of relative distribution of ketamine and norketamine in decomposed skeletal tissues following single and repeated exposures.

    abstract：:Bone was analyzed for ketamine and norketamine to examine whether different patterns of drug exposure could be discriminated. Rats received (intraperitoneally) one 75 mg/kg dose (Acute-1 and Acute-2 groups), three 25-mg/kg doses 1 hour apart (Repeated group), or nine single daily ketamine doses of 75 mg/kg followed by...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/bks045

    authors： Watterson JH,Donohue JP,Betit CC

    更新日期：2012-07-01 00:00:00

  • Identification of basic drugs in urine by dual fused silica capillary column GC.

    abstract：:A method for analyzing urine for the presence of basic drugs and their metabolites using two fused silica capillary columns is described along with operating conditions and column characteristics. Urine extracts were injected into a gas chromatograph equipped with nitrogen phosphorous detectors (GC/NPD) and two capill...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/6.5.247

    authors： Hime GW,Bednarczyk LR

    更新日期：1982-09-01 00:00:00

  • Determination of naltrexone and 6-beta-naltrexol in plasma by solid-phase extraction and gas chromatography-negative ion chemical ionization-mass spectrometry.

    abstract：:Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...

    journal_title：Journal of analytical toxicology

    pub_type： 临床试验,杂志文章

    doi：10.1093/jat/21.4.252

    authors： Huang W,Moody DE,Foltz RL,Walsh SL

    更新日期：1997-07-01 00:00:00

  • Quantification of atrazine, phenylurea, and sulfonylurea herbicide metabolites in urine by high-performance liquid chromatography-tandem mass spectrometry.

    abstract：:We developed a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method to measure metabolites of atrazine, phenylurea, and sulfonylurea herbicides in human urine. The metabolites measured in the method include atrazine mercapturate, desethyl atrazine, and desisopropyl atrazine as markers of...

    journal_title：Journal of analytical toxicology

    pub_type： 杂志文章

    doi：10.1093/jat/31.4.181

    authors： Nguyen JV,Olsson AO,Bravo R,Needham LL,Barr DB

    更新日期：2007-05-01 00:00:00