Abstract:
:Metabolism experiments were conducted with rats dosed with nine azo dyes based on dimethyl-, dimethoxy-, or dichlorobenzidine to determine whether the free amine congeners, their monoacetyl or diacetyl metabolites, or alkaline hydrolyzable conjugates were excreted in the urine. After preliminary tests of the dyes, 2-mg doses were administered to each animal and urine samples were collected at intervals up to 96 hours. EC/GC procedures were based on the analysis of heptafluorobutyryl derivatives of the free amine congener moieties or their monoacetyl metabolites. Peak levels of metabolites were excreted either 0-12 or 12-24 hours after administration and, in seven of nine instances, no metabolites persisted in the urine after 48 hours. Minimum detectable levels of all metabolites were 12 ppb or less. All nine dyes were shown to be converted to measurable levels of their benzidine-congener-based metabolites in rats.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Bowman MC,Nony CR,Billedeau SM,Martin JL,Thompson HC Jr,Lowry LKdoi
10.1093/jat/7.1.55subject
Has Abstractpub_date
1983-01-01 00:00:00pages
55-60issue
1eissn
0146-4760issn
1945-2403journal_volume
7pub_type
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