Modified Method for Detection of Benzoylecgonine in Human Urine by GC-MS: Derivatization Using Pentafluoropropanol/Acetic Anhydride.

abstract：:Separating drugs which are both polar and basic has long been difficult because of the limited operating pH range of conventional HPLC columns. This paper describes a liquid chromatographic method capable of being used with either diode-array or mass spectrometric detection for the identification and quantitation of 1...

journal_title：Journal of analytical toxicology

authors： Goeringer KE,McIntyre lM,Drummer OH

更新日期：2003-01-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:A rapid, reproducible and sensitive reversed phase liquid chromatography-mass spectrometry method was developed and validated for the identification and semi-quantitative confirmation of stimulants in urine. The method is capable of separating compounds such as cocaine and metabolites, amphetamines, substituted cathin...

journal_title：Journal of analytical toxicology

authors： O'Byrne PM,Kavanagh PV,McNamara SM,Stokes SM

更新日期：2013-03-01 00:00:00

abstract：:Since the introduction in 1990, the solid-phase microextraction (SPME) technology has brought significant progress in many fields of forensic sciences due to the versatility of this fast and solventless alternative to conventional extraction techniques. A systematic review about SPME applications in forensic context f...

journal_title：Journal of analytical toxicology

authors： De Giovanni N,Marchetti D

更新日期：2020-04-30 00:00:00

abstract：:Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...

journal_title：Journal of analytical toxicology

authors： Wells DJ,Hanks BM,Yarbrough CS,Davis MA

更新日期：1988-01-01 00:00:00

abstract：:A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, ...

journal_title：Journal of analytical toxicology

authors： Chung H,Choi H,Kim E,Jin W,Lee H,Yoo Y

更新日期：2000-05-01 00:00:00

abstract：:A method is presented for the extraction and screening of basic and neutral drugs, including amphetamines. Two milliliters of blood are buffered to pH 9.0 and extracted with n-chlorobutane. Underivatized extracts are analyzed simultaneously on two complementary capillary columns placed together in one injection port u...

journal_title：Journal of analytical toxicology

authors： Watts VW,Simonick TF

更新日期：1986-09-01 00:00:00

abstract：:The content, chemical form, and distribution of mercury and selenium in edible tissue were determined for several samples of fish and other marine animal organisms (mollusks, crustaceans and pods). For most fish samples, except Pacific blue marlin, 53 to 94% of the total mercury content was present as methylmercury, b...

journal_title：Journal of analytical toxicology

authors： Cappon CJ,Smith JC

更新日期：1982-01-01 00:00:00

abstract：INTRODUCTION:We encountered unexpected false positive urine results in three patients for amphetamine-type substances by immunoassay, measured as part of community drug prevention programmes. Kavain was identified in all three urine samples by gas chromatography mass spectrometry (GC-MS). No other potential cross-react...

journal_title：Journal of analytical toxicology

authors： Madhavaram H,Patel T,Kyle C

更新日期：2020-12-16 00:00:00

abstract：:Different analytical procedures for quantitation of total morphine and codeine in urine were evaluated. Hydrolysis of urine with hydrochloric acid and four different enzymes was compared. In order to effect complete hydrolysis of glucuronide conjugates, hydrolysis with 6.5M HCl containing bisulphite and heating at 100...

journal_title：Journal of analytical toxicology

authors： Lin Z,Lafolie P,Beck O

更新日期：1994-05-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:This work was aimed at developing and validating a hydrophilic interaction chromatography (HILIC)-electrospray ionization (ESI)-ion trap-tandem mass spectrometric method for identification and quantification of ethyl glucuronide (ETG) and ethyl sulfate (ETS) as ethanol biomarkers and at employing this method for analy...

journal_title：Journal of analytical toxicology

authors： Al-Asmari AI,Anderson RA,Appelblad P

更新日期：2010-06-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the...

journal_title：Journal of analytical toxicology

authors： Stein EA

更新日期：2001-07-01 00:00:00

abstract：:Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen...

journal_title：Journal of analytical toxicology

authors： Hubbard JA,Navarrete AL,Fitzgerald RL,McIntyre IM

更新日期：2019-11-06 00:00:00

abstract：:Endogenous γ-hydroxybutyric acid (GHB) concentrations in blood and urine are well documented, but there are very little data on natural levels in saliva, a biological matrix increasingly used for drug testing. We measured endogenous GHB concentrations in 120 unpaid volunteers who also provided anonymous epidemiologica...

journal_title：Journal of analytical toxicology

authors： De Paoli G,Walker KM,Pounder DJ

更新日期：2011-04-01 00:00:00

abstract：:The stability of nortriptyline in aqueous solutions containing various concentrations of formaldehyde was investigated. Amitriptyline, as a reaction product, was determined by gas chromatography/mass spectrometry (GC/MS) in these experiments. Factors that may contribute to this phenomenon, including pH, formaldehyde c...

journal_title：Journal of analytical toxicology

authors： Dettling RJ,Briglia EJ,Dal Cortivo LA,Bidanset JH

更新日期：1990-09-01 00:00:00

abstract：:Urine specimens containing 11 common beta blockers were processed using solid-phase extraction technology to extract the drugs from the urine matrix, then converted to their cyclic methaneboronates by treatment with methaneboronic acid in ethyl acetate. The compounds tested included acebutolol, atenolol, alprenolol, b...

journal_title：Journal of analytical toxicology

authors： Branum GD,Sweeney S,Palmeri A,Haines L,Huber C

更新日期：1998-03-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is an endogenous compound, but its presence in postmortem blood presents a challenge when interpreting elevated levels as GHB is misused as a recreational drug and is also produced postmortem. A total of 387 postmortem cases (273 male and 114 female) submitted to the toxicology laboratory b...

journal_title：Journal of analytical toxicology

authors： Korb AS,Cooper G

更新日期：2014-10-01 00:00:00

abstract：:A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was red...

journal_title：Journal of analytical toxicology

authors： Caplan YH,Orloff KG,Thompson BC

更新日期：1980-05-01 00:00:00

abstract：:Metabolism experiments were conducted with rats dosed with nine azo dyes based on dimethyl-, dimethoxy-, or dichlorobenzidine to determine whether the free amine congeners, their monoacetyl or diacetyl metabolites, or alkaline hydrolyzable conjugates were excreted in the urine. After preliminary tests of the dyes, 2-m...

journal_title：Journal of analytical toxicology

authors： Bowman MC,Nony CR,Billedeau SM,Martin JL,Thompson HC Jr,Lowry LK

更新日期：1983-01-01 00:00:00

abstract：:Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substance...

journal_title：Journal of analytical toxicology

authors： Kim JY,Suh S,Park J,In MK

更新日期：2018-11-01 00:00:00

abstract：:For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...

journal_title：Journal of analytical toxicology

authors： Gullberg RG

更新日期：2012-04-01 00:00:00

abstract：:A fatal case attributed to flecainide intoxication is presented. Quantitation was by capillary gas chromatography with nitrogen-phosphorus detection. The flecainide concentration in the blood was 13 mg/L as compared to a therapeutic range in serum of 0.2-1.0 mg/L. Flecainide concentrations in other specimens were as f...

journal_title：Journal of analytical toxicology

authors： Levine B,Chute D,Caplan YH

更新日期：1990-09-01 00:00:00

abstract：:A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...

journal_title：Journal of analytical toxicology

authors： Gaudette NF,Lodge JW

更新日期：2005-01-01 00:00:00

abstract：:A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F...

journal_title：Journal of analytical toxicology

authors： Poklis A,Backer R

更新日期：2004-09-01 00:00:00

abstract：:Analytical methods were developed to determine the presence of ethylenediaminetetraacetic acid (EDTA) in dried bloodstains to provide probative information when allegations of evidence tampering have been made in criminal cases. A simple screening method using ion chromatography to analyze stains was found to be quant...

journal_title：Journal of analytical toxicology

authors： Miller ML,McCord BR,Martz R,Budowle B

更新日期：1997-11-01 00:00:00

abstract：:3-Fluorophenmetrazine (3-FPM) is a stimulant-like novel psychoactive substance (NPS) and fluorinated analog of phenmetrazine that has recently appeared on the recreational drug market, with limited published information. Likewise, the synthetic opioid U-47700 has gained popularity among recreational drug users and is ...

journal_title：Journal of analytical toxicology

authors： Ellefsen KN,Taylor EA,Simmons P,Willoughby V,Hall BJ

更新日期：2017-11-01 00:00:00

abstract：:Fentanyl and its analogs, such as acetylfentanyl, have become a concern for potential abuse. Fentanyl compliance monitoring and urine drug testing are becoming increasingly necessary; however, a limited number of fentanyl immunoassays have been validated for clinical use. The purpose of this study was to validate the ...

journal_title：Journal of analytical toxicology

authors： Wang BT,Colby JM,Wu AH,Lynch KL

更新日期：2014-11-01 00:00:00

abstract：:A gas chromatographic (GC) method was developed for the detection of propylene glycol dinitrate (PGDN) in rodent skin following extraction with ethyl acetate. Known quantities of PGDN contained in the torpedo fuel Otto Fuel II were added to homogenates of rat skin, which were subsequently extracted with two 10-mL port...

journal_title：Journal of analytical toxicology

authors： Godin CS,Pollard DL

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to develop, optimize, and validate an analytical procedure to determine a group of eight amphetamines, amphetamine (AMP), ephedrine (EP), methcathinone (MTC), paramethoxyamphetamine (PMA), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methyle...

journal_title：Journal of analytical toxicology

authors： Stanaszek R,Piekoszewski W

更新日期：2004-03-01 00:00:00