Abstract：
:The content, chemical form, and distribution of mercury and selenium in edible tissue were determined for several samples of fish and other marine animal organisms (mollusks, crustaceans and pods). For most fish samples, except Pacific blue marlin, 53 to 94% of the total mercury content was present as methylmercury, being notably higher in freshwater species. Other marine organisms, except shrimp, contained only 29 to 47% methylmercury. For all samples, a significant part of the total selenium content (4 to 47%) was present as selenate (Se VI). Tissue selenium levels did not correlate with corresponding mercury levels. In freshwater and older processed (canned) marine fish, except marlin, 55 to 80% of the total mercury content was water-extractable. For non-processed (fresh) and newly-processed marine samples, only 22 to 47% was extractable. On a percentage basis, inorganic mercury was generally more extractable than methylmercury. For all fish samples, except marlin, 55 to 60% of the total selenium content was water-extractable, while only 35 to 45% was extractable for other marine species. On a percentage basis, Se VI was more extractable than selenite (Se IV) and selenide (Se II).
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Cappon CJ,Smith JCdoi
10.1093/jat/6.1.10subject
Has Abstractpub_date
1982-01-01 00:00:00pages
10-21issue
1eissn
0146-4760issn
1945-2403journal_volume
6pub_type
杂志文章abstract：:From a public health point of view, cocaine (COC) presents serious clinical problems and deaths from overdose and lifelong addiction patterns, not to mention its involvement in crime, in the United States. This study subjected rhesus monkeys to one intravenous administration of COC (1 mg/kg), which closely imitates th...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.7.571
更新日期：1995-11-01 00:00:00
abstract：:A sensitive and reproducible gas chromatographic procedure for the quantitative determination of urinary o-cresol is described. The first step involves acid hydrolysis (2N HCl, 100 degrees C, 10 min), which yields unconjugated o-cresol. After extraction (methylene chloride, pH 2), the organic layer is concentrated by ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/20.5.309
更新日期：1996-09-01 00:00:00
abstract：:A rapid and simple liquid chromatography tandem mass spectrometry method was developed and validated for the simultaneous determination of L-ephedrine, pseudoephedrine, and caffeine in male Fisher-344 rat plasma at nanogram-per-milliliter concentrations for use in support of toxicology studies. Only 25 μL of plasma is...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.6.341
更新日期：2011-07-01 00:00:00
abstract：:Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/17.7.436
更新日期：1993-11-01 00:00:00
abstract：:The aim of this study was to investigate the early-phase postmortem redistribution of the enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) in a rat model. Furthermore, we wanted to examine the role of the lungs as a reservoir of postmortem drug release and ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/29.4.223
更新日期：2005-05-01 00:00:00
abstract：:Conditions for the enzymatic hydrolysis of benzodiazepine conjugates were systematically examined. Optimal recovery of the free drugs occurs when 1 mL of urine buffered to pH 4.5 is incubated with 5000 U of Helix pomatia beta-glucuronidase at 56 degrees C for 2 h. Urine specimens containing conjugates of temazepam, ox...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/18.7.382
更新日期：1994-11-01 00:00:00
abstract：:3-Fluorophenmetrazine (3-FPM) is a stimulant-like novel psychoactive substance (NPS) and fluorinated analog of phenmetrazine that has recently appeared on the recreational drug market, with limited published information. Likewise, the synthetic opioid U-47700 has gained popularity among recreational drug users and is ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkx060
更新日期：2017-11-01 00:00:00
abstract：:The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic chec...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/34.3.155
更新日期：2010-04-01 00:00:00
abstract：:The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/33.1.56
更新日期：2009-01-01 00:00:00
abstract：:A method for the simultaneous analysis of cocaine (COC), derivatized benzoylecgonine (BE), and derivatized ecgonine methyl ester (EME) has been developed. Blood or urine containing deuterated analogs of the three analytes is extracted by pouring over a Chem-Elut column and eluting with chloroform/isopropanol (9:1). Th...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/12.5.242
更新日期：1988-09-01 00:00:00
abstract：:This study of 20,089 urine specimens from chronic pain patients provided a unique opportunity to evaluate the prevalence of prescription opiates and metabolites, assess the usefulness of inclusion of normetabolites in the test panel, and compare opiate and oxycodone screening results to liquid chromatography with tand...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/34.1.32
更新日期：2010-01-01 00:00:00
abstract：:Hydrocodone in combination with acetaminophen is commonly used to control moderate pain and is metabolized by cytochrome P4502D6 to form the active metabolite, hydromorphone. The purpose of this study was to determine the metabolic relationship and variability between hydrocodone and its conversion to hydromorphone us...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks019
更新日期：2012-05-01 00:00:00
abstract：:Benzoylecgonine (BZE) extraction from urine was explored using Cerex Polycrom Clin II solid-phase extraction (SPE) columns and the Speedisk 48 Pressure Processor as an alternative to the Prep1 automated sample processor and XTRX Type RP/W columns. Linearity for urine standards extracted using the Cerex-Speedisk method...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/25.7.616
更新日期：2001-10-01 00:00:00
abstract：:We present data from the analysis of the alcohol content of 391 beers and malt beverages available for sale in the State of Washington. The beverages were tested by gas chromatography for their alcohol content. Considerable variability in the alcoholic strength was found, even within the same class. Overall, the range...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.3.202
更新日期：2000-04-01 00:00:00
abstract：:A suicide caused by oral ingestion of colchicine is reported. Postmortem examination revealed circulating Pelger-Huet polymorphonuclear leukocytes and numerous mitotic and chromatin bodies in tissues with rapid cell turnover. Colchicine was identified by gas chromatography/mass spectrometry (GC/MS) of an organic extra...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/15.3.151
更新日期：1991-05-01 00:00:00
abstract：:Niflumic acid is a nonsteroidal, anti-inflammatory drug widely prescribed in Greece. We recently noticed that this drug cross-reacts for cannabinoids in a kinetic interaction of microparticles in a solution (KIMS) immunoassay method but does not in an enzyme multiplied immunoassay technique (EMIT) immunoassay method. ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/34.4.229
更新日期：2010-05-01 00:00:00
abstract：:A gas chromatographic (GC) method was developed for the detection of propylene glycol dinitrate (PGDN) in rodent skin following extraction with ethyl acetate. Known quantities of PGDN contained in the torpedo fuel Otto Fuel II were added to homogenates of rat skin, which were subsequently extracted with two 10-mL port...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/16.6.356
更新日期：1992-11-01 00:00:00
abstract：:Bisphenol S (BPS) has been detected in personal care products, water, food and indoor house dust, demonstrating the potential for human exposure. Due to limited data to characterize the hazard of BPS, the National Toxicology Program (NTP) is investigating the toxicity of BPS in rodent models. Generating systemic expos...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkab008
更新日期：2021-01-09 00:00:00
abstract：:The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.9.613
更新日期：2011-11-01 00:00:00
abstract：:A method for analyzing urine for the presence of basic drugs and their metabolites using two fused silica capillary columns is described along with operating conditions and column characteristics. Urine extracts were injected into a gas chromatograph equipped with nitrogen phosphorous detectors (GC/NPD) and two capill...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.5.247
更新日期：1982-09-01 00:00:00
abstract：:Two cases of lethal overdose by temazepam are presented. In both cases, temazepam was the only drug detected, and there was no involvement of alcohol. The drug concentrations in blood, urine, and liver were measured. ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/10.2.77
更新日期：1986-03-01 00:00:00
abstract：:The National Institute of Standards and Technology (formerly the National Bureau of Standards), in cooperation with the College of American Pathologists (CAP), has certified the concentrations of phencyclidine (PCP) in two new reference materials (RMs). One of these materials is Standard Reference Material (SRM) 1511,...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/20.1.43
更新日期：1996-01-01 00:00:00
abstract：:Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章,评审
doi：10.1093/jat/30.2.65
更新日期：2006-03-01 00:00:00
abstract：:Baclofen (Lioresal), a lipophilic analogue of c-aminobutyric acid (GABA), and carisoprodol (Soma), a central nervous system depressant with an unknown mechanism of pharmacologic action, are categorized as muscle relaxants. Baclofen is used clinically in the management of spasticity and its sequelae secondary to severe...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/27.5.275
更新日期：2003-07-01 00:00:00
abstract：:We present a method that permits the simultaneous analysis of carbamazepine (CBZ) and its major biotransformation products, carbamazepine-10,11-epoxide (CBZ-E) and carbamazepine-10,11-dihydroxide (CBZ-diOH), in plasma samples. The method consists of plasma extraction in alkaline medium with NaCl added using chloroform...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/16.2.88
更新日期：1992-03-01 00:00:00
abstract：:This study identified ethyl sulfate (EtS) in human urine and compared the excretion characteristics of EtS with that of ethanol and ethyl glucuronide (EtG). Urine samples were collected from healthy subjects after a single ethanol dose, and also selected from routine clinical samples. Simultaneous analysis of EtS and ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/29.5.270
更新日期：2005-07-01 00:00:00
abstract：:An enzyme multiplied immunoassay technique (EMIT) was used to test for opiates (morphine, hydromorphone, and codeine) in extracts of blood, bile, and tissue homogenates. All immunoassay opiate positive specimens were then tested by a reversed-phase liquid chromatographic procedure using electrochemical detection (LCEC...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/8.2.78
更新日期：1984-03-01 00:00:00
abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/17.1.14
更新日期：1993-01-01 00:00:00
abstract：:Gas chromatographic methods have been developed using a Supelco 1240-DA column for the determination of pentachlorophenol (PCP) in plasma and urine samples, and phenol in urine samples. These methods required no derivatization. Electron capture detection has been used for PCP determination, while flame ionization dete...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.6.297
更新日期：1982-11-01 00:00:00
abstract：:For many reasons, forensic toxicologists are being asked to determine and report their measurement uncertainty in blood alcohol analysis. While understood conceptually, the elements and computations involved in determining measurement uncertainty are generally foreign to most forensic toxicologists. Several establishe...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks012
更新日期：2012-04-01 00:00:00
