Development and validation of a high-performance liquid chromatography method for the evaluation of niflumic acid cross-reactivity of two commercial immunoassays for cannabinoids in urine.

abstract：:Benzoylecgonine (BZE) extraction from urine was explored using Cerex Polycrom Clin II solid-phase extraction (SPE) columns and the Speedisk 48 Pressure Processor as an alternative to the Prep1 automated sample processor and XTRX Type RP/W columns. Linearity for urine standards extracted using the Cerex-Speedisk method...

journal_title：Journal of analytical toxicology

authors： Kuhnle JA,Churley M,Kawasaki SY,Lyons TP,Bruins MR

更新日期：2001-10-01 00:00:00

abstract：:The present study evaluates the suitability of headspace gas chromatography (GC) with a capillary column as a method for determining the ethanol content in different biological fluids. This procedure allows the use of headspace GC not only as a reference method but also in routine diagnostics and monitoring work. The ...

journal_title：Journal of analytical toxicology

authors： Macchia T,Mancinelli R,Gentili S,Lugaresi EC,Raponi A,Taggi F

更新日期：1995-07-01 00:00:00

abstract：:A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monk...

journal_title：Journal of analytical toxicology

authors： Yamamoto T,Takano R,Egashira T,Yamanaka Y,Terada M

更新日期：1989-03-01 00:00:00

abstract：:A high performance liquid chromatographic method is reported, which incorporates three internal standards (I-cinchonidine, N-propylprocainamide, and para-chlorodisopyramide) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: quinidine, procainamide, N-acetylprocainamide, and disopyrami...

journal_title：Journal of analytical toxicology

authors： Bridges RR,Jennison TA

更新日期：1983-03-01 00:00:00

abstract：:Cannabinoids were extracted from serum with C18 SPE cartridges and analyzed as their trimethylsilyl (TMS) derivatives. A benchtop gas chromatography-tandem mass spectrometry (GC-MS-MS) system based on an ion trap with external ionization was used. Quantitation was done in relation to trideuterated internal standards i...

journal_title：Journal of analytical toxicology

authors： Weller JP,Wolf M,Szidat S

更新日期：2000-07-01 00:00:00

abstract：:The opioids codeine and morphine have legitimate uses in managing chronic pain conditions, but they are frequently abused. Patients prescribed opioids submit urine samples for medication compliance monitoring, and the interpretation of the results is complex. The purpose of this study was to evaluate the percentage of...

journal_title：Journal of analytical toxicology

authors： Colby JM,Wu AH,Lynch KL

更新日期：2015-06-01 00:00:00

abstract：:A simple and sensitive method for determination of N,N-dimethyltryptamine (DMT) by gas chromatography (GC) with surface ionization detection (SID) is presented. Whole blood or urine, containing DMT and gramine (internal standard), was subjected to solid-phase extraction with a Sep-Pak C18 cartridge before analysis by ...

journal_title：Journal of analytical toxicology

authors： Ishii A,Seno H,Suzuki O,Hattori H,Kumazawa T

更新日期：1997-01-01 00:00:00

abstract：:Sixteen apparently intact procainamide tablets, in varied stages of drug depletion, were found distributed throughout the gastrointestinal tract of a man who died of arteriosclerotic heart disease with pulmonary complications. The tablets were found to contain procainamide by a thin layer chromatography system with ca...

journal_title：Journal of analytical toxicology

authors： Griesemer EC

更新日期：1984-09-01 00:00:00

abstract：:Cocaine is among the illicit substances most frequently implicated in deaths related to the use of drugs of abuse both worldwide and in Italy. Cutting agents involved in the adulterations of this substance are many and the process of lacing can take place at various stages of the production of the drug. In this Report...

journal_title：Journal of analytical toxicology

authors： Di Candia D,Boracchi M,Muccino E,Gentile G,Zoja R

更新日期：2021-01-08 00:00:00

abstract：:Analysis and interpretation of the findings for the drug of abuse gamma hydroxybutyric acid (GHB) in fatalities has become very problematic. This is primarily because of variable data in postmortem biological fluids resulting from the endogenous nature of the compound, possible postmortem production, and varying metho...

journal_title：Journal of analytical toxicology

authors： Elliott SP

更新日期：2004-01-01 00:00:00

abstract：:Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...

journal_title：Journal of analytical toxicology

authors： Wells DJ,Hanks BM,Yarbrough CS,Davis MA

更新日期：1988-01-01 00:00:00

abstract：:Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen...

journal_title：Journal of analytical toxicology

authors： Hubbard JA,Navarrete AL,Fitzgerald RL,McIntyre IM

更新日期：2019-11-06 00:00:00

abstract：:Urine specimens containing 11 common beta blockers were processed using solid-phase extraction technology to extract the drugs from the urine matrix, then converted to their cyclic methaneboronates by treatment with methaneboronic acid in ethyl acetate. The compounds tested included acebutolol, atenolol, alprenolol, b...

journal_title：Journal of analytical toxicology

authors： Branum GD,Sweeney S,Palmeri A,Haines L,Huber C

更新日期：1998-03-01 00:00:00

abstract：:This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Kintz P,Dubois N,Plomteux G

更新日期：2004-03-01 00:00:00

abstract：:High levels of verapamil (1) were found in the blood, stomach contents, and liver and kidney specimens in a fatal overdose case. The drug was extracted from both acid and enzyme digested tissue with ether, chloroform, and 1-chlorobutane and the digests analysed by both high-performance liquid chromatography and gas ch...

journal_title：Journal of analytical toxicology

authors： Thomson BM,Pannell LK

更新日期：1981-05-01 00:00:00

abstract：:Use of methiopropamine (MPA), a synthetic metamfetamine analog, has been detected since 2011 in Europe, but there is limited information on its acute toxicity. A 30-year-old man was admitted to the emergency department in a confused state, with paranoid delusion, auditory and visual hallucinatory experiences, and inco...

journal_title：Journal of analytical toxicology

authors： Daveluy A,Castaing N,Cherifi H,Richeval C,Humbert L,Faure I,Labadie M,Allorge D,Haramburu F,Molimard M,Titier K

更新日期：2016-11-01 00:00:00

abstract：:In June 1986, an epidemic of poisoning occurred in Sierra Leone, West Africa; it involved 49 persons--with 14 deaths. Our laboratory's approach and investigation of this incident is described. Using positive chemical ionization mass spectrometry and nuclear magnetic resonance spectroscopy, the toxicant was identified ...

journal_title：Journal of analytical toxicology

authors： Hill RH Jr,Alley CC,Ashley DL,Cline RE,Head SL,Needham LL,Etzel RA

更新日期：1990-07-01 00:00:00

abstract：:Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 micrograms/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 m...

journal_title：Journal of analytical toxicology

authors： Lehmann T,Sager F,Brenneisen R

更新日期：1997-09-01 00:00:00

abstract：:The effects of decomposition microclimate on the distribution of dextromethorphan (DXM) and dextrorphan (DXT) in skeletonized remains of rats acutely exposed to DXM were examined. Animals (n = 10) received DXM (75 mg/kg, i.p.), were euthanized 30 min post-dose and immediately allowed to decompose at either Site A (sha...

journal_title：Journal of analytical toxicology

authors： Unger KA,Watterson JH

更新日期：2016-10-01 00:00:00

abstract：:Intoxications with the antifreeze constituent ethylene glycol (EG) occur infrequently, but may be fatal if not recognized and treated promptly. The aim of the present work was to develop an analytical method for rapid diagnosis of EG poisoning and for monitoring EG removal by hemodialysis. EG was measured by gas chrom...

journal_title：Journal of analytical toxicology

authors： Aarstad K,Dale O,Aakervik O,Ovrebø S,Zahlsen K

更新日期：1993-07-01 00:00:00

abstract：:The Rapid Stat assay, a point-of-collection drug-testing device for detection of amphetamines, cannabinoids, cocaine, opiates, methadone, and benzodiazepines in oral fluid, was evaluated for cannabis and amphetamine-type stimulants. The Rapid Stat tests (n = 134) were applied by police officers in routine traffic chec...

journal_title：Journal of analytical toxicology

authors： Röhrich J,Zörntlein S,Becker J,Urban R

更新日期：2010-04-01 00:00:00

abstract：:Cyclizine is an antihistamine with sedative effect used to treat motion sickness. A few studies have reported on cyclizine abuse among teenagers, and cyclizine abuse has been reported among opioid dependants receiving methadone, with the combination having been reported to produce strong psychoactive effects. Few repo...

journal_title：Journal of analytical toxicology

authors： Arnestad M,Eldor KB,Stray-Pedersen A,Bachs L,Karinen R

更新日期：2014-03-01 00:00:00

abstract：:The National Institute of Standards and Technology (formerly the National Bureau of Standards), in cooperation with the College of American Pathologists (CAP), has certified the concentrations of phencyclidine (PCP) in two new reference materials (RMs). One of these materials is Standard Reference Material (SRM) 1511,...

journal_title：Journal of analytical toxicology

authors： Tai SS,Christensen RG,Coakley K,Ellerbe P,Long T,Welch MJ

更新日期：1996-01-01 00:00:00

abstract：:Synthetic cathinones have recently emerged as a substitute for common drugs of abuse. Synthetic cathinones can elicit powerful adverse effects such as delusions, hallucinations and potentially dangerous behavior. To develop a method to analyze 10 synthetic cathinones in oral fluid, we implemented a combined approach o...

journal_title：Journal of analytical toxicology

authors： Amaratunga P,Lorenz Lemberg B,Lemberg D

更新日期：2013-11-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...

journal_title：Journal of analytical toxicology

authors： Nishida K,Itoh S,Inoue N,Kudo K,Ikeda N

更新日期：2006-05-01 00:00:00

abstract：:A selected ion monitoring gas chromatographic/mass spectrometric method for the quantitative determination of benzene in air, breath, and blood was developed utilizing a headspace assay with benzene-d3 as an internal standard. Limits of detection for 2 ng/mL in blood and 0.1 ppb in a 5-L sample of air or breath were a...

journal_title：Journal of analytical toxicology

authors： Gruenke LD,Craig JC,Wester RC,Maibach HI

更新日期：1986-11-01 00:00:00

abstract：:A 38-year-old man was admitted in the intensive care unit (ICU) after supposed ingestion of 504 sustained-release tablets of Theralithe™ corresponding ~200 g of lithium carbonate. At the admission, ~19.5 h after ingestion, the patient was conscious with trembling limbs, intense thirst, profuse sweats and vomiting and ...

journal_title：Journal of analytical toxicology

authors： Jamal T,Hennequin C,Gahoual R,Leyris A,Beaudeux JL,Baud FJ,Houzé P

更新日期：2019-08-23 00:00:00

abstract：:Selegiline (SE) is a selective, irreversible monoamine oxidase-B inhibitor, used for reducing symptoms in early-stage Parkinson's disease. The metabolites of SE include l-methamphetamine, l-amphetamine and desmethylselegiline (DSE). The stereoisomers of SE metabolites, d-methamphetamine and d-amphetamine are highly ad...

journal_title：Journal of analytical toxicology

authors： Shin I,Choi H,Kang S,Kim J,Park Y,Yang W

更新日期：2020-05-30 00:00:00

abstract：:A method utilizing microwave dissolution in a closed Teflon bomb followed by hydride generation atomic absorption spectrometry has been used for the routine analysis of arsenic in fish species from the coast of the province of Granada, Spain. The technique was evaluated for decomposing biological standard reference ma...

journal_title：Journal of analytical toxicology

authors： Navarro M,López H,López MC,Sánchez M

更新日期：1992-05-01 00:00:00