Abstract:
:Cocaine is among the illicit substances most frequently implicated in deaths related to the use of drugs of abuse both worldwide and in Italy. Cutting agents involved in the adulterations of this substance are many and the process of lacing can take place at various stages of the production of the drug. In this Report we are discussing the case of a 27-year-old woman found death next to her car in a wooded area in the suburban area of Milan. On the crime scene, several specimens of white powder were collected and subsequently analyzed via Q-Exactive Orbitrap with a HPLC system and LC/MS-MS analysis along with biological matrices sampled during autopsy examination. The toxicological analysis revealed that the death could be ascribed to a lethal dose of methomyl, a carbamide pesticide used as cutting agent for cocaine. According to Literature, this is the first time that this substance is used as an adulterant.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Di Candia D,Boracchi M,Muccino E,Gentile G,Zoja Rdoi
10.1093/jat/bkab006subject
Has Abstractpub_date
2021-01-08 00:00:00eissn
0146-4760issn
1945-2403pii
6070627pub_type
杂志文章abstract::In an effort to determine a practical, efficient, and economical alternative for the use of a radioimmunoassay (RIA) for the detection of lysergic acid diethylamide (LSD) in human urine, the performance of two photometric immunoassays (Dade Behring EMIT II and Microgenics CEDIA) and the Diagnostics Products Corp. (DPC...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.7.519
更新日期:2002-10-01 00:00:00
abstract::A comparison was made of several cannabinoid urine assays. Two hundred randomly selected urine specimens were initially screened by two enzyme immunoassays (EMIT-st and EMIT-d.a.u.) and a radioimmunoassay (Abuscreen RIA). Selected specimens found positive by any of these methods were further analyzed by gas-liquid chr...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/8.4.192
更新日期:1984-07-01 00:00:00
abstract::Given that external contamination must be considered in hair analysis, there is still a demand for reliable tools to differentiate between incorporation of drugs into the hair as a result of drug consumption and of the hair shaft by external contamination. With the aim of establishing alternative discrimination parame...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz022
更新日期:2019-08-23 00:00:00
abstract::Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.6.509
更新日期:1996-10-01 00:00:00
abstract::Amoxicillin has been causally linked in the lay and medical literature to false-positive urine drug screens for cocaine metabolites. An exhaustive search of the peer-reviewed medical literature revealed no data to support this link. We hypothesized that amoxicillin does not cause false-positive urine drug screens for ...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
doi:10.1093/jat/32.4.315
更新日期:2008-05-01 00:00:00
abstract::Hypertension is one of the most important modifiable risk factor causing cardiovascular disease. Unfortunately, non-adherence to antihypertensive medications is frequently observed in hypertensive patients and can lead to an increase in morbidity and mortality. Until recently, there was no robust clinical method to ob...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkaa192
更新日期:2020-12-10 00:00:00
abstract::A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.1.14
更新日期:1993-01-01 00:00:00
abstract::In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.3.179
更新日期:2001-04-01 00:00:00
abstract::A colchicine blood concentration 250 microgram/L was determined in a 39-year-old white female 2 hours following the ingestion of an oral overdose of the drug. At death, 40 hours following ingestion, no drug was detected. Colchicine was extracted from buffered blood using dichloromethane. The evaporated extract was red...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/4.3.153
更新日期:1980-05-01 00:00:00
abstract::To determine the degree of ethanol absorption and the resultant formation and urinary excretion of its conjugated metabolites following intensive use of high ethanol content mouthwash, 10 subjects gargled with Listerine(®) antiseptic 4 times daily for 3¼ days. First morning void urine specimens were collected on each ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.5.264
更新日期:2011-06-01 00:00:00
abstract::Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz057
更新日期:2019-09-10 00:00:00
abstract::We present data from the analysis of the alcohol content of 391 beers and malt beverages available for sale in the State of Washington. The beverages were tested by gas chromatography for their alcohol content. Considerable variability in the alcoholic strength was found, even within the same class. Overall, the range...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/24.3.202
更新日期:2000-04-01 00:00:00
abstract::A new tetracyclic antidepressant drug, maprotiline hydrochloride was found to be the agent of death in a 23-year-old subject following massive injestion (4.5-6.0 g). The case may be the first reported maprotiline death (sole cause) in the United States. Analytical parameters were studies and various chromatographic an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.4.199
更新日期:1982-07-01 00:00:00
abstract::We present a method that permits the simultaneous analysis of carbamazepine (CBZ) and its major biotransformation products, carbamazepine-10,11-epoxide (CBZ-E) and carbamazepine-10,11-dihydroxide (CBZ-diOH), in plasma samples. The method consists of plasma extraction in alkaline medium with NaCl added using chloroform...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/16.2.88
更新日期:1992-03-01 00:00:00
abstract::Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章,评审
doi:10.1093/jat/25.5.419
更新日期:2001-07-01 00:00:00
abstract::We report a case involving unusually high postmortem morphine concentrations in a 44-year-old male with end-stage pancreatic cancer. He was receiving morphine for pain control via a single subclavian intravenous catheter. Allegations of foul play were made by family members at the time of death, so a full autopsy was ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.6.529
更新日期:2004-09-01 00:00:00
abstract::A relatively simple procedure for the determination of carboxyhemoglobin percent saturation in postmortem samples is described. The procedure involves a quick and accurate method for calibration of the gas chromatograph to carbon monoxide. The mixed gases are extracted from blood prior to introduction into the gas chr...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/4.4.181
更新日期:1980-07-01 00:00:00
abstract::Proton nuclear magnetic resonance spectroscopy (1H MRS) has been used to identify ethanol in vivo and to detect other exogenous low molecular weight volatiles in human serum. 1H MRS was used to detect and quantitate 15 human sera containing various concentrations and combinations of ethanol, isopropanol, acetone, and ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.5.273
更新日期:1993-09-01 00:00:00
abstract::The U.S. Drug Enforcement Administration has several different systems for collecting information on drugs of abuse. One is an early warning system, which collects information to provide scientific data and interpretation on drug abuse. Another is the collection of data from evidence submitted to DEA laboratories. Thi...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/11.6.237
更新日期:1987-11-01 00:00:00
abstract::A case of lethal overdose by heroin ingestion is presented. The concentrations of drugs were measured several hours after death. Heroin, 06-monoacetylmorphine, and morphine were identified and quantitated in blood, urine, and gastrointestinal contents by gas chromatography-mass spectrometry and high-performance liquid...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/21.3.232
更新日期:1997-05-01 00:00:00
abstract::Methyl methacrylate polymer (PolyMMA) is widely used as the composite resin for the dental plate. During the fabrication process of PolyMMA for the polymerization reaction, benzoylperoxide (BPO) and N,N-dimethyl p-toluidine (DMPT) are added as the initiator and the stimulator, respectively. Because these compounds exh...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.2.73
更新日期:1993-03-01 00:00:00
abstract::A sensitive and robust ultra-high-performance liquid chromatography-tandem mass spectrometry method has been developed and validated for the quantification of acetaminophen, dexchlorpheniramine, caffeine, cotinine and salicylic acid in postmortem blood samples from children younger than 4 years. The sample was prepare...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkx089
更新日期:2018-03-01 00:00:00
abstract::A hair screening method has been developed for the detection of methamphetamine using an immunoassay analyzer (AxSYM) with a fluorescence polarization immunoassay (FPIA) technique. The method consisted of washing, cutting and digesting a hair sample (5 mg) with an enzymatic digestion solution. The digested hair sample...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt011
更新日期:2013-05-01 00:00:00
abstract::A high performance liquid chromatographic method is reported, which incorporates three internal standards (I-cinchonidine, N-propylprocainamide, and para-chlorodisopyramide) for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: quinidine, procainamide, N-acetylprocainamide, and disopyrami...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/7.2.65
更新日期:1983-03-01 00:00:00
abstract::From a public health point of view, cocaine (COC) presents serious clinical problems and deaths from overdose and lifelong addiction patterns, not to mention its involvement in crime, in the United States. This study subjected rhesus monkeys to one intravenous administration of COC (1 mg/kg), which closely imitates th...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.7.571
更新日期:1995-11-01 00:00:00
abstract::The application of gas chromatography/mass spectrometry (GC/MS) for the simultaneous quantitation of seven commonly encountered urinary benzodiazepine metabolites is described. After comparison of the signal-to-noise ratios of high mass ions of benzodiazepines using electron impact (EI), positive chemical ionization (...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.6.342
更新日期:1993-10-01 00:00:00
abstract::The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.3.109
更新日期:1982-05-01 00:00:00
abstract::Urine drug testing is common for workplace drug testing, prescription management, emergency medicine and the criminal justice system. Unsurprisingly, with the significant consequences based upon the results of urine drug testing, a donor in need of concealing the contents of their sample is highly motivated to cheat t...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw119
更新日期:2017-03-01 00:00:00
abstract::We report the validation of a quantitative method for paraquat in plasma and urine using high-performance liquid chromatography (HPLC) with ultraviolet detection (260 nm). Furthermore, we illustrate the use of this method in the clinic (over five years), in conjunction with a qualitative urine paraquat screen. Urine o...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.6.456
更新日期:2001-09-01 00:00:00
abstract::Ethanol is the most frequently identified compound in forensic toxicology. Although confirmation involving mass spectrometry is desirable, relatively few methods have been published to date. A novel technique utilizing a Dean's Switch to simultaneously quantitate and confirm ethyl alcohol by flame-ionization (FID) and...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.7.501
更新日期:2011-09-01 00:00:00