Abstract：
:From a public health point of view, cocaine (COC) presents serious clinical problems and deaths from overdose and lifelong addiction patterns, not to mention its involvement in crime, in the United States. This study subjected rhesus monkeys to one intravenous administration of COC (1 mg/kg), which closely imitates the smoking of "crack" COC with regard to dose and effect. We monitored plasma concentrations over time, beginning when the primates were in a state of hyperarousal. Blood was sampled at 1, 6, 12, and 40 min after dosing. Plasma concentrations of COC decreased rapidly with a half life of 15.7 min. Mean COC concentrations in the drug-treated group (n = 7) for the four timepoints were 296, 225, 187, and 80 ng/mL, respectively. Ecgonine methyl ester (EME) concentrations ranged from 57 to 91 ng/mL. When compared with the 1-min COC concentrations, the mean EME concentration was 30.7%. Benzoylecgonine (BZE) ranged from 34 to 42 ng/mL, and the mean concentration was 11.5% of the mean COC concentration at 1 min. EME and BZE concentrations did not vary appreciably over the time course of the study. Plasma norcocaine concentrations were less than the limit of detection of 25 ng/mL. Because a rapid decline in plasma COC concentrations over time was observed along with a very small change in EME and BZE concentrations, we attribute tissue redistribution of COC, particularly to the brain, as significant and metabolism or hydrolysis of COC as minor.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Saady JJ,Bowman ER,Aceto MDdoi
10.1093/jat/19.7.571subject
Has Abstractpub_date
1995-11-01 00:00:00pages
571-5issue
7eissn
0146-4760issn
1945-2403journal_volume
19pub_type
杂志文章abstract：:Vitreous humor is a potential alternative matrix for postmortem toxicology drug screens when peripheral blood is unavailable. It is easily and reliably collected and may not suffer from the same postmortem redistribution as seen in blood. Here, we compared the concentrations of 7 acidic drugs (acetaminophen, ibuprofen...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkz076
更新日期：2019-11-06 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/bku121
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abstract：:Sampling and drug stability in oral fluid (OF) are crucial factors when interpreting forensic toxicological analysis, mainly because samples may not be analyzed immediately after collection, potentially altering drug concentrations. Therefore, the stability of some common drugs of abuse (morphine, codeine, 6-monoacety...
journal_title：Journal of analytical toxicology
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doi：10.1093/jat/bkz114
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.1.54
更新日期：2000-01-01 00:00:00
abstract：:The National Institute of Standards and Technology (formerly the National Bureau of Standards), in cooperation with the College of American Pathologists (CAP), has certified the concentrations of phencyclidine (PCP) in two new reference materials (RMs). One of these materials is Standard Reference Material (SRM) 1511,...
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doi：10.1093/jat/20.1.43
更新日期：1996-01-01 00:00:00
abstract：:A method is presented for the extraction and screening of basic and neutral drugs, including amphetamines. Two milliliters of blood are buffered to pH 9.0 and extracted with n-chlorobutane. Underivatized extracts are analyzed simultaneously on two complementary capillary columns placed together in one injection port u...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/10.5.198
更新日期：1986-09-01 00:00:00
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更新日期：2013-11-01 00:00:00
abstract：:A method for determining the chemical warfare agent soman (GD) in rat plasma has been validated and applied to low-level inhalation exposure studies currently being conducted. This method utilizes a fluoride ion-based regeneration assay with isotope dilution followed by large volume injection gas chromatography with a...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/32.1.92
更新日期：2008-01-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/19.5.323
更新日期：1995-09-01 00:00:00
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doi：10.1093/jat/25.1.45
更新日期：2001-01-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/21.2.127
更新日期：1997-03-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkv122
更新日期：2016-03-01 00:00:00
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journal_title：Journal of analytical toxicology
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更新日期：2014-10-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.2.115
更新日期：1995-03-01 00:00:00
abstract：:The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...
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pub_type： 杂志文章
doi：10.1093/jat/6.3.109
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/27.6.366
更新日期：2003-09-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/28.6.485
更新日期：2004-09-01 00:00:00
abstract：:A sensitive and specific method was developed for the quantitative analysis of l-alpha-acetylmethadol (LAAM), l-alpha-acetyl-N-normethadol (norLAAM), and l-alpha-acetyl-N,N-dinormethadol (dinorLAAM) in hair. In the development of this method, it was determined that sample pretreatment methods performed by the laborato...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/21.6.420
更新日期：1997-10-01 00:00:00
abstract：:A high-performance liquid chromatographic system based on gradient elution of an alumina packing material coated with polybutadiene is presented. The chromatographic eluent is a mixture of methanol and water, both containing 0.0125M NaOH. The effluent is monitored by photodiode array detection. The system allows detec...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/19.2.73
更新日期：1995-03-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/14.1.39
更新日期：1990-01-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/26.1.6
更新日期：2002-01-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章,多中心研究
doi：10.1093/jat/bky011
更新日期：2018-06-01 00:00:00
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更新日期：2009-10-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/25.7.559
更新日期：2001-10-01 00:00:00
abstract：:Oxymorphone, a semi-synthetic opioid analgesic, has been available as Numorphan since the 1950s in the form of injectable solutions and a suppository. Recently, in 2006, oxymorphone was approved by the Federal Drug Administration for use in the form of immediate and extended release tablets under the trade name Opana....
journal_title：Journal of analytical toxicology
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更新日期：2009-04-01 00:00:00
abstract：:A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exch...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bku141
更新日期：2015-03-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/28.5.384
更新日期：2004-07-01 00:00:00
abstract：:Confirmation of drugs of abuse by gas chromatography-mass spectrometry (GC-MS) is the most time-consuming process used by drug-testing laboratories. Cost effectiveness and competitive turnaround times for testing results demand fast, efficient, and reliable extraction methods. We applied the Cerex Polycrom-THC solid-p...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/24.4.245
更新日期：2000-05-01 00:00:00
abstract：:As part of a search for phencyclidine (PCP) antagonists, a series of eleven aryl-substituted PCP analogs were prepared and characterized. TLC and GC elution profiles of these derivatives are described in a number of systems allowing for the tentative identification of the PCP analogs. Further, MS, NMR, UV/vis and IR s...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/7.5.252
更新日期：1983-09-01 00:00:00
abstract：:Bone was analyzed for ketamine and norketamine to examine whether different patterns of drug exposure could be discriminated. Rats received (intraperitoneally) one 75 mg/kg dose (Acute-1 and Acute-2 groups), three 25-mg/kg doses 1 hour apart (Repeated group), or nine single daily ketamine doses of 75 mg/kg followed by...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bks045
更新日期：2012-07-01 00:00:00
