Abstract：
:From a public health point of view, cocaine (COC) presents serious clinical problems and deaths from overdose and lifelong addiction patterns, not to mention its involvement in crime, in the United States. This study subjected rhesus monkeys to one intravenous administration of COC (1 mg/kg), which closely imitates the smoking of "crack" COC with regard to dose and effect. We monitored plasma concentrations over time, beginning when the primates were in a state of hyperarousal. Blood was sampled at 1, 6, 12, and 40 min after dosing. Plasma concentrations of COC decreased rapidly with a half life of 15.7 min. Mean COC concentrations in the drug-treated group (n = 7) for the four timepoints were 296, 225, 187, and 80 ng/mL, respectively. Ecgonine methyl ester (EME) concentrations ranged from 57 to 91 ng/mL. When compared with the 1-min COC concentrations, the mean EME concentration was 30.7%. Benzoylecgonine (BZE) ranged from 34 to 42 ng/mL, and the mean concentration was 11.5% of the mean COC concentration at 1 min. EME and BZE concentrations did not vary appreciably over the time course of the study. Plasma norcocaine concentrations were less than the limit of detection of 25 ng/mL. Because a rapid decline in plasma COC concentrations over time was observed along with a very small change in EME and BZE concentrations, we attribute tissue redistribution of COC, particularly to the brain, as significant and metabolism or hydrolysis of COC as minor.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Saady JJ,Bowman ER,Aceto MDdoi
10.1093/jat/19.7.571subject
Has Abstractpub_date
1995-11-01 00:00:00pages
571-5issue
7eissn
0146-4760issn
1945-2403journal_volume
19pub_type
杂志文章abstract：:The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/31.6.342
更新日期：2007-07-01 00:00:00
abstract：:3-Fluorophenmetrazine (3-FPM) is a stimulant-like novel psychoactive substance (NPS) and fluorinated analog of phenmetrazine that has recently appeared on the recreational drug market, with limited published information. Likewise, the synthetic opioid U-47700 has gained popularity among recreational drug users and is ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkx060
更新日期：2017-11-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/6.3.153
更新日期：1982-05-01 00:00:00
abstract：:Gas chromatographic methods have been developed using a Supelco 1240-DA column for the determination of pentachlorophenol (PCP) in plasma and urine samples, and phenol in urine samples. These methods required no derivatization. Electron capture detection has been used for PCP determination, while flame ionization dete...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.6.297
更新日期：1982-11-01 00:00:00
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doi：10.1093/jat/20.7.522
更新日期：1996-11-01 00:00:00
abstract：:The objective of this project was to validate a new high-throughput homogeneous enzyme immunoassay (HEIA) for the rapid detection of carisoprodol in human urine. Carisoprodol (Soma(®)) and meprobamate are widely prescribed as musculoskeletal pain relief drugs and are listed as one of the 10 most frequently identified ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/anatox/35.2.108
更新日期：2011-03-01 00:00:00
abstract：:A 24-year-old man known to consume illegal drugs was found dead in his apartment. A reclosable plastic zipper bag containing several hundred milligrams of a brown powder was found close to the dead body and the first assumption of the investigators was death due to heroin intoxication. Therefore, a legal autopsy was o...
journal_title：Journal of analytical toxicology
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/29.1.28
更新日期：2005-01-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/10.2.41
更新日期：1986-03-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/16.4.261
更新日期：1992-07-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2004-09-01 00:00:00
abstract：:Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章,评审
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abstract：:The Substance Abuse and Mental Health Services Administration (SAMHSA) is currently evaluating hydrocodone (HC) for inclusion in the Mandatory Guidelines for Federal Workplace Drug Testing Programs. This study evaluated the time course of HC, norhydrocodone (NHC), dihydrocodeine (DHC) and hydromorphone (HM) in paired ...
journal_title：Journal of analytical toxicology
pub_type： 临床试验,杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/14.1.29
更新日期：1990-01-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkx089
更新日期：2018-03-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/23.7.565
更新日期：1999-11-01 00:00:00
abstract：:Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable. Consequently, most laboratories employ liquid chromatography-tandem mass spectrometry (LC-MS-MS) screening, which can be complex ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkw025
更新日期：2016-06-01 00:00:00
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journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/4.4.181
更新日期：1980-07-01 00:00:00
abstract：:Analytical methods were developed to determine the presence of ethylenediaminetetraacetic acid (EDTA) in dried bloodstains to provide probative information when allegations of evidence tampering have been made in criminal cases. A simple screening method using ion chromatography to analyze stains was found to be quant...
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pub_type： 杂志文章
doi：10.1093/jat/21.7.521
更新日期：1997-11-01 00:00:00
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journal_title：Journal of analytical toxicology
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journal_title：Journal of analytical toxicology
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更新日期：2013-09-01 00:00:00
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journal_title：Journal of analytical toxicology
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doi：10.1093/jat/19.6.375
更新日期：1995-10-01 00:00:00
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journal_title：Journal of analytical toxicology
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更新日期：1993-01-01 00:00:00
abstract：:Endogenous γ-hydroxybutyric acid (GHB) concentrations in blood and urine are well documented, but there are very little data on natural levels in saliva, a biological matrix increasingly used for drug testing. We measured endogenous GHB concentrations in 120 unpaid volunteers who also provided anonymous epidemiologica...
journal_title：Journal of analytical toxicology
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更新日期：2011-04-01 00:00:00
abstract：:A rapid capillary gas-liquid chromatographic method for the determination of barbiturates in plasma at concentrations of clinical importance is presented. This method employs a rapid and simple extraction procedure and direct flame ionization detection with no derivatization. ...
journal_title：Journal of analytical toxicology
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doi：10.1093/jat/7.4.178
更新日期：1983-07-01 00:00:00
abstract：:Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...
journal_title：Journal of analytical toxicology
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更新日期：1997-07-01 00:00:00
abstract：:A simple, rapid, and reliable gas-liquid chromatographic (GLC) confirmation procedure was developed for urine samples found positive by the EMIT-dau benzodiazepine metabolite assay. The procedure involves acid hydrolysis, organic extraction, and identification using GLC-nitrogen-phosphorus detection (NPD). The method ...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/6.6.305
更新日期：1982-11-01 00:00:00
abstract：:Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control...
journal_title：Journal of analytical toxicology
pub_type： 杂志文章
doi：10.1093/jat/bkx001
更新日期：2017-05-01 00:00:00
abstract：:In preparation for a treatment program concerning the medical coprescription of heroin and methadone to treatment-resistant addicts in the Netherlands, we studied a novel strategy for monitoring co-use of illicit (nonprescribed) heroin. A deuterated analogue of heroin was added (1:20) to pharmaceutical, smokable heroi...
journal_title：Journal of analytical toxicology
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doi：10.1093/jat/29.6.564
更新日期：2005-09-01 00:00:00
