Abstract:
:A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exchanger. Extracts are measured with liquid chromatography coupled with electrospray tandem mass spectrometry. The method was successfully validated according to the guidelines of the 'Society of Toxicological and Forensic Chemistry' (GTFCh). To obtain reference material hair was soaked in a solution of the analytes in dimethyl sulfoxide/methanol to allow incorporation into the hair. These fortified hair samples were used for method development and can be employed as quality controls.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Martin R,Schürenkamp J,Gasse A,Pfeiffer H,Köhler Hdoi
10.1093/jat/bku141subject
Has Abstractpub_date
2015-03-01 00:00:00pages
126-9issue
2eissn
0146-4760issn
1945-2403pii
bku141journal_volume
39pub_type
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