Abstract:
:As part of a search for phencyclidine (PCP) antagonists, a series of eleven aryl-substituted PCP analogs were prepared and characterized. TLC and GC elution profiles of these derivatives are described in a number of systems allowing for the tentative identification of the PCP analogs. Further, MS, NMR, UV/vis and IR spectral tabulations are provided. Correlation of chromatographic character with physical organic structure parameters, such as those of Hammet, showed good predictability.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Costa JF,Speaker TJdoi
10.1093/jat/7.5.252subject
Has Abstractpub_date
1983-09-01 00:00:00pages
252-6issue
5eissn
0146-4760issn
1945-2403journal_volume
7pub_type
杂志文章abstract::In mothers who had no prenatal care and in their newborns, the presence of cocaine and benzoylecgonine (BE) was determined in urine, hair, and meconium. Samples of urine and hair were obtained from pregnant women who entered the hospital for delivery. Cocaine usage was assessed by a urinary enzyme-multiplied immunoass...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/18.5.247
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abstract::A high-performance liquid chromatographic system based on gradient elution of an alumina packing material coated with polybutadiene is presented. The chromatographic eluent is a mixture of methanol and water, both containing 0.0125M NaOH. The effluent is monitored by photodiode array detection. The system allows detec...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.2.73
更新日期:1995-03-01 00:00:00
abstract::Postmortem redistribution (PMR) constitutes a multifaceted process, which complicates the interpretation of drug concentrations by forensic toxicologists. The present study aimed to apply quantitative structure-activity relationship (QSAR) analysis for modeling PMR data of structurally related drugs, 10 benzodiazepine...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku025
更新日期:2014-06-01 00:00:00
abstract::In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.3.179
更新日期:2001-04-01 00:00:00
abstract::3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive, synthetic analog of the central nervous system stimulant cathinone. Its recent popularity as a recreational drug in the United States has led to numerous reports to poison control centers across the country. As with other synthetic cathinones, the recreational u...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkt001
更新日期:2013-04-01 00:00:00
abstract::The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.678
更新日期:2005-10-01 00:00:00
abstract::A method for analyzing urine for the presence of basic drugs and their metabolites using two fused silica capillary columns is described along with operating conditions and column characteristics. Urine extracts were injected into a gas chromatograph equipped with nitrogen phosphorous detectors (GC/NPD) and two capill...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.5.247
更新日期:1982-09-01 00:00:00
abstract::A 59-year-old white male accidentally ingested a mouthful of a plant growth chemical, Cycocel, containing 11.8% of the active ingredient (2-chloroethyl)trimethylammonium chloride (chlormequat). He was seen by a family physician and then transferred to a hospital where he died as a result of ventricular fibrillation, w...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/14.4.257
更新日期:1990-07-01 00:00:00
abstract::Vitreous humor is a fluid contained in the eye that is largely composed of water. The advantages of vitreous humor as a specimen for postmortem drug analysis include its relatively low susceptibility to contamination and the ability to analyze vitreous humor with little or no pretreatment. The postmortem analysis of e...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/31.8.537
更新日期:2007-10-01 00:00:00
abstract::An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram. ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.5.260
更新日期:1982-09-01 00:00:00
abstract::A method is presented for the analysis of trace amounts of dinitroaniline herbicides in tissue and excreta. The method employs extraction of the tissue or excreta with organic solvent, clean up by liquid/liquid partitioning or silica gel chromatography, and ultimate analysis by gas chromatography using electron captur...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.1.15
更新日期:1985-01-01 00:00:00
abstract::A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During samplin...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.2.160
更新日期:2008-03-01 00:00:00
abstract::The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/33.1.56
更新日期:2009-01-01 00:00:00
abstract::Pharmacogenomics is the study of the linkage between an individual's genotype and the disposition of drugs in the body. The first association between adverse drug reactions and inherited variations was recognized in the 1950s, and since then, pharmacogenomics has come a long way. The importance of pharmacogenomics is ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章,评审
doi:10.1093/jat/30.2.65
更新日期:2006-03-01 00:00:00
abstract::An ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of 25 common pharmaceuticals in whole blood. The selected pharmaceuticals represent the most frequently detected drugs in our forensic laboratory with basic properties such as analgesics, antid...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks054
更新日期:2012-09-01 00:00:00
abstract::Exposure to drugs and toxins is a major cause for the rising number of emergency department visits each year. Immunoassays are commonly used in the emergency department to provide rapid turnaround time for acute care. The purpose of this study was to compare two automated immunoassay chemistry analyzers to determine w...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks028
更新日期:2012-06-01 00:00:00
abstract::This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.8.810
更新日期:2005-11-01 00:00:00
abstract::A simple, rapid ethanol screen based on a microdiffusion technique (Analytical Systems, Marion Laboratories) has been evaluated and compared to an established enzymatic procedure (Abbott TDx). They showed agreement in 484 of 488 biological specimens and all control specimens. They disagreed on 4 specimens--3 positive ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/12.6.348
更新日期:1988-11-01 00:00:00
abstract::A sensitive and reproducible gas chromatographic procedure for the quantitative determination of urinary o-cresol is described. The first step involves acid hydrolysis (2N HCl, 100 degrees C, 10 min), which yields unconjugated o-cresol. After extraction (methylene chloride, pH 2), the organic layer is concentrated by ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.5.309
更新日期:1996-09-01 00:00:00
abstract::In this study, the relationships between the concentrations of R/S-methamphetamine (MA) and its metabolite R/S-amphetamine (AP), the AP/MA ratio in hair samples, and MA dependence were investigated by performing segmental hair analysis in MA users. Authentic hair samples collected from 10 chronic MA abusers were cut i...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz089
更新日期:2020-07-31 00:00:00
abstract::In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a fast (15 min) comprehensive screening method for 500 toxicologically relevant analytes based on ultra-performance liquid chromatography (UPLC) coupled with a quadrupol...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/34.9.571
更新日期:2010-11-01 00:00:00
abstract::Draft guidelines for the use of oral fluid for workplace drug testing are under development by the Substance Abuse and Mental Health Services Administration (SAMHSA) in cooperation with industry and researchers. Comparison studies of the effectiveness of oral fluid testing versus urine testing are needed to establish ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.8.541
更新日期:2002-11-01 00:00:00
abstract::The Abbott TDx Urine Amphetamine/Methamphetamine II fluorescence polarization immunoassay technique was applied to the determination of D-methamphetamine in hemolyzed whole blood. The assay was found to have 100% cross-reactivity with D-methamphetamine and only an 8% cross-reactivity with L-methamphetamine. Whole bloo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/16.2.115
更新日期:1992-03-01 00:00:00
abstract::As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as flunitrazepam in Taiwan. Alleged misuses of this substance h...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.2.118
更新日期:2005-03-01 00:00:00
abstract::A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. Th...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz017
更新日期:2019-08-23 00:00:00
abstract::A simple, time-saving procedure to measure aluminum (AI) in whole blood, plasma, and water samples of low ionic strength by flameless atomic absorption spectrometry is presented. With this procedure, an analagous pretreatment is given to all samples. Moreover, the pretreated samples are analyzed using an identical pro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.3.97
更新日期:1985-05-01 00:00:00
abstract::In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites. Urine specimens (N = 1689) were collected during elimination of cannabinoids from 25 subjects with a history of marijuana use. Specimens were analyzed conc...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.7.559
更新日期:2001-10-01 00:00:00
abstract::The quantification of drugs of abuse in keratinized matrices is becoming of special relevance for monitoring consumption and for post-mortem investigations. We aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone (MET), 2-ethylidene-1,5-dime...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkx099
更新日期:2018-04-01 00:00:00
abstract::Ethiofencarb is one of the carbamate compounds, which are, in general, less toxic than organophosphorus insecticides. This is due to their reversible acetylcholinesterase inhibition and relative inability to cross the blood-brain barrier. Generally, ethiofencarb is regarded to be of low toxicity (LD(50) > 200 mg/kg); ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/33.7.389
更新日期:2009-09-01 00:00:00
abstract::Amoxicillin has been causally linked in the lay and medical literature to false-positive urine drug screens for cocaine metabolites. An exhaustive search of the peer-reviewed medical literature revealed no data to support this link. We hypothesized that amoxicillin does not cause false-positive urine drug screens for ...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
doi:10.1093/jat/32.4.315
更新日期:2008-05-01 00:00:00