Cannabinoid concentrations in spot serum samples 24-48 hours after discontinuation of cannabis smoking.

abstract：:An improved method has been developed for the quantitative determination of cyanide in human blood by headspace gas chromatography with electron-capture detection. In this novel method, cyanide was detected after conversion of hydrogen cyanide into cyanogen chloride by a reaction with chloramine T. The advantage of th...

journal_title：Journal of analytical toxicology

authors： Odoul M,Fouillet B,Nouri B,Chambon R,Chambon P

更新日期：1994-07-01 00:00:00

abstract：:Sixteen apparently intact procainamide tablets, in varied stages of drug depletion, were found distributed throughout the gastrointestinal tract of a man who died of arteriosclerotic heart disease with pulmonary complications. The tablets were found to contain procainamide by a thin layer chromatography system with ca...

journal_title：Journal of analytical toxicology

authors： Griesemer EC

更新日期：1984-09-01 00:00:00

abstract：:An existing GC-MS method for detecting benzoylecgonine (BZE) in urine was modified by changing derivatizing reagents. This method modification presents a cost-effective alternative derivatization procedure for the detection of BZE in urine by GC-MS. The combination of pentafluoropropanol and acetic anhydride was found...

journal_title：Journal of analytical toxicology

authors： Serafin MC,Paulemon KM,Fuller ZJ,Bronner WE

更新日期：2017-05-01 00:00:00

abstract：:This article reports the impact of diuresis on urinary excretion of ethanol in seven healthy volunteers who drank 1000 mL of export beer (44 g ethanol) in 30 min and, 120 min later, ingested 500 or 1000 mL of water within 5 min. Urine was voided before drinking started and every 30-60 min for 360 min after the start o...

journal_title：Journal of analytical toxicology

authors： Bendtsen P,Jones AW

更新日期：1999-11-01 00:00:00

abstract：:During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. A case recently received by CAMI screened positive for the anticonvulsant medication carbamazepine (CBZ;...

journal_title：Journal of analytical toxicology

authors： Lewis RJ,Angier MK,Johnson RD

更新日期：2014-10-01 00:00:00

abstract：:Clonazepam, nitrazepam and flunitrazepam are frequently used benzodiazepines, both as prescribed medication and as drugs of abuse. Little is, however, known about how these drugs are excreted in oral fluid. It has been claimed that the parent drugs are more likely to be detected in oral fluid than the 7-amino metaboli...

journal_title：Journal of analytical toxicology

authors： Vindenes V,Strand DH,Koksæter P,Gjerde H

更新日期：2016-05-01 00:00:00

abstract：:Selegiline (SE) is a selective, irreversible monoamine oxidase-B inhibitor, used for reducing symptoms in early-stage Parkinson's disease. The metabolites of SE include l-methamphetamine, l-amphetamine and desmethylselegiline (DSE). The stereoisomers of SE metabolites, d-methamphetamine and d-amphetamine are highly ad...

journal_title：Journal of analytical toxicology

authors： Shin I,Choi H,Kang S,Kim J,Park Y,Yang W

更新日期：2020-05-30 00:00:00

abstract：:This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...

journal_title：Journal of analytical toxicology

authors： Buzalaf MA,Caroselli EE,de Carvalho JG,de Oliveira RC,da Silva Cardoso VE,Whitford GM

更新日期：2005-11-01 00:00:00

abstract：:Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...

journal_title：Journal of analytical toxicology

authors： Guan F,Seno H,Ishii A,Watanabe K,Kumazawa T,Hattori H,Suzuki O

更新日期：1999-01-01 00:00:00

abstract：:The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods ...

journal_title：Journal of analytical toxicology

authors： Ellerbe P,Long T,Welch MJ

更新日期：1993-05-01 00:00:00

abstract：:The measurement of cefoperazone concentrations in cerebral spinal fluid (CSF) is important to understanding the biodisposition and pharmacokinetic behavior of the drug. We have demonstrated that cefoperazone is unstable in methanol and at alkaline pH and these factors may affect the accurate quantitation of the drug i...

journal_title：Journal of analytical toxicology

authors： Kinniburgh DW,Jennison TA,Matsen JM

更新日期：1982-03-01 00:00:00

abstract：:Two cases of death following the ingestion of tranylcypromine are presented. High concentrations of tranylcypromine were determined in blood, urine, and liver by gas-liquid chromatography. Tranylcypromine was extracted from buffered blood with n-butyl chloride. The evaporated extract was derivatized with trifluoroacet...

journal_title：Journal of analytical toxicology

authors： Boniface PJ

更新日期：1991-01-01 00:00:00

abstract：:Suvorexant (Belsomra®) is a novel dual orexin receptor antagonist used for the treatment of insomnia. The prevalence of suvorexant in forensic samples is relatively unknown, which demonstrates the need for robust analytical assays for the detection of this sedative hypnotic in forensic toxicology laboratories. In this...

journal_title：Journal of analytical toxicology

authors： Skillman B,Kerrigan S

更新日期：2020-04-30 00:00:00

abstract：:Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...

journal_title：Journal of analytical toxicology

authors： Vikingsson S,Rautio T,Wallgren J,Åstrand A,Watanabe S,Dahlén J,Wohlfarth A,Konradsson P,Wu X,Kronstrand R,Gréen H

更新日期：2019-09-10 00:00:00

abstract：:Feces are a possible medium to be used for horse doping control. Efficient methods for detecting drugs in feces collected from various animals are routinely applied in institutes of food safety in Belgium. We have already tested whether they are applicable to horse feces. In this report, accelerated solvent extraction...

journal_title：Journal of analytical toxicology

authors： Popot MA,Donval A,Bonnaire Y,Huau J

更新日期：2006-06-01 00:00:00

abstract：:The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...

journal_title：Journal of analytical toxicology

authors： Cooper G,Wilson L,Reid C,Baldwin D,Hand C,Spiehler V

更新日期：2005-10-01 00:00:00

abstract：:A high-performance liquid chromatographic method was used for the detection of etodolac in equine serum and urine. The method consisted of a one-step liquid-liquid extraction, separation on a reversed-phase (RP-18) column and detection using an ultraviolet detector. Additional confirmation methods included a HPLC coup...

journal_title：Journal of analytical toxicology

authors： Koupai-Abyazani MR,Esaw B,Laviolette B

更新日期：1999-05-01 00:00:00

abstract：:Publications reporting concentrations of caffeine in postmortem blood were reviewed if the cause of death was attributed to overdosing (poisoning) with drugs. Age and gender of the deceased, the manner of death (accident, suicide or undetermined) and types of co-ingested drugs were evaluated in relation to the concent...

journal_title：Journal of analytical toxicology

authors： Jones AW

更新日期：2017-04-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the simultaneous determination of Delta(9)-tetrahydrocannabinol (THC), 11-hydroxy-Delta(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol (THC-COOH) in whole blo...

journal_title：Journal of analytical toxicology

authors： Jamey C,Szwarc E,Tracqui A,Ludes B

更新日期：2008-06-01 00:00:00

abstract：:Toxicological analyses of medicines and chemicals in formaldehyde-treated specimens are a component of forensic toxicology. This review involves two parts: (i) reactions of formaldehyde with substances in tissues fixed with formalin (aqueous formaldehyde solution) and (ii) the stability of substances in formalin-treat...

journal_title：Journal of analytical toxicology

authors： Takayasu T

更新日期：2013-11-01 00:00:00

abstract：:The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...

journal_title：Journal of analytical toxicology

authors： Sokoro A,Lehotay D,Eichhorst J,Treble R

更新日期：2007-07-01 00:00:00

abstract：:Bone was analyzed for ketamine and norketamine to examine whether different patterns of drug exposure could be discriminated. Rats received (intraperitoneally) one 75 mg/kg dose (Acute-1 and Acute-2 groups), three 25-mg/kg doses 1 hour apart (Repeated group), or nine single daily ketamine doses of 75 mg/kg followed by...

journal_title：Journal of analytical toxicology

authors： Watterson JH,Donohue JP,Betit CC

更新日期：2012-07-01 00:00:00

abstract：:While circumventing legislative controls, synthetic piperazines are encountered as "legal" alternatives to ecstasy. Unforeseeable challenges may delay quantitative analysis of these compounds in biological fluids. Enzymatic reactions, matrix interferences and limited knowledge of analyte stability further complicate i...

journal_title：Journal of analytical toxicology

authors： Lau T,LeBlanc R,Botch-Jones S

更新日期：2018-03-01 00:00:00

abstract：:We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at p...

journal_title：Journal of analytical toxicology

authors： Guillot JG,Lefebvre M,Weber JP

更新日期：1997-03-01 00:00:00

abstract：:A case of lethal overdose by prilocaine, a local anaesthetic, is presented. The patient died in the dental office during treatment, and the time course of events was documented. The drug concentration in blood, urine, and liver was measured. ...

journal_title：Journal of analytical toxicology

authors： Kaliciak HA,Chan SC

更新日期：1986-03-01 00:00:00

abstract：:Hop-derived iso-α-acid (IAA) ingredient congeners are specific to beer. Concentrations of IAAs were determined in blood of five volunteers over 6 h following the consumption of small volumes of beer containing relatively high (Pale Ale beer) or low (wheat beer) concentrations of IAAs. IAAs were quickly absorbed with p...

journal_title：Journal of analytical toxicology

authors： Rodda LN,Gerostamoulos D,Drummer OH

更新日期：2014-07-01 00:00:00

abstract：:Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen ...

journal_title：Journal of analytical toxicology

authors： Moore C,Dempsey D,Deitermann D,Lewis D,Leikin J

更新日期：1996-10-01 00:00:00

abstract：:Six cases involving the antidepressant mirtazapine were analyzed in detail at the San Diego County Medical Examiner's Office from 2004 to 2005. Mirtazapine was initially detected and confirmed in each of these cases by a liquid-liquid gas chromatography (GC)-MS basic drug screen. Following another liquid-liquid basic ...

journal_title：Journal of analytical toxicology

authors： Kirkton C,McIntyre IM

更新日期：2006-11-01 00:00:00

abstract：:A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium...

journal_title：Journal of analytical toxicology

authors： Pershing LK,Peat MA,Finkle BS

更新日期：1982-05-01 00:00:00

abstract：:The List of Prohibited Substances and Methods (the List), an International Standard published yearly by the World Anti-Doping Agency (WADA), determines which substances and methods are prohibited in sport in- and out-of-competition. Stimulants are included within drug class S.6 under the in-competition testing sectio...

journal_title：Journal of analytical toxicology

authors： Boghosian T,Mazzoni I,Barroso O,Rabin O

更新日期：2011-11-01 00:00:00