Monitoring of aluminum in whole blood, plasma, serum, and water by a single procedure using flameless atomic absorption spectrophotometry.

abstract：:A sensitive and specific method was developed for the quantitative analysis of l-alpha-acetylmethadol (LAAM), l-alpha-acetyl-N-normethadol (norLAAM), and l-alpha-acetyl-N,N-dinormethadol (dinorLAAM) in hair. In the development of this method, it was determined that sample pretreatment methods performed by the laborato...

journal_title：Journal of analytical toxicology

authors： Wilkins DG,Valdez AS,Krueger GG,Rollins DE

更新日期：1997-10-01 00:00:00

abstract：:The guidelines for screening of urinary cannabinoids require that all specimens testing positive should be confirmed by gas chromatography-mass spectrometry at a confirmatory test cutoff value of 15 ng/mL of 11-nor-9-carboxy-Δ9-tetrahydrocannabinol (THCCOOH). To assess the impact of lowering the confirmatory test cuto...

journal_title：Journal of analytical toxicology

authors： Lecompte Y,Perrin M,Salle S,Roussel O

更新日期：2012-10-01 00:00:00

abstract：:Pigmented (C57BI) and nonpigmented (balb/c) mice, 25 days of age, were treated intraperitoneally with [3H]-nicotine (4 mg/kg, 555 dpm/ng) or [3H]-flunitrazepam (1 mg/kg, 2200 dpm/ng) daily for three days. After 21 days, shaved back hair was digested at 37 degrees C for 24 h with either 1 M sodium hydroxide or 1 M sodi...

journal_title：Journal of analytical toxicology

authors： Claffey DJ,Stout PR,Ruth JA

更新日期：2000-01-01 00:00:00

abstract：:Previous measurements of elemental concentrations in liver mitochondria have generally required homogenization and fractionation of liver tissue, a procedure in which it is difficult to rule out ion movement between subcellular units. New techniques involving cryoultramicrotomy of rapidly frozen tissue, high resolutio...

journal_title：Journal of analytical toxicology

authors： Millette JR,Allenspach AL,Clark PJ,McCauley PT,Washington IS

更新日期：1985-07-01 00:00:00

abstract：:Four kinds of volatile anesthetics (halothane, enflurane, isoflurane, and sevoflurane) that were dissolved in 3 microL of experimental plasma samples were examined by the pulse-heating gas chromatographic-mass spectrometric method, and this approach was found to be reliable for qualitative and quantitative analysis. T...

journal_title：Journal of analytical toxicology

authors： Saito K,Takayasu T,Nishigami J,Kondo T,Ohtsuji M,Lin Z,Ohshima T

更新日期：1995-03-01 00:00:00

abstract：:We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium. The FPIA is sensitiv...

journal_title：Journal of analytical toxicology

authors： Clark GD,Rosenzweig IB,Raisys V,Callahan CM,Grant TM,Streissguth AP

更新日期：1992-07-01 00:00:00

abstract：:The metabolism of N-benzylpiperazine (BZP), a recently scheduled designer drug, in the rat has been studied by analyzing its urinary metabolites. p-Hydroxy-BZP (p-OH-BZP) was unequivocally identified as the main metabolite along with a minor metabolite m-hydroxy-BZP (m-OH-BZP), using gas chromatography-mass spectromet...

journal_title：Journal of analytical toxicology

authors： Tsutsumi H,Katagi M,Miki A,Shima N,Kamata T,Nakajima K,Inoue H,Kishi T,Tsuchihashi H

更新日期：2006-01-01 00:00:00

abstract：:We developed a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS-MS) method to measure metabolites of atrazine, phenylurea, and sulfonylurea herbicides in human urine. The metabolites measured in the method include atrazine mercapturate, desethyl atrazine, and desisopropyl atrazine as markers of...

journal_title：Journal of analytical toxicology

authors： Nguyen JV,Olsson AO,Bravo R,Needham LL,Barr DB

更新日期：2007-05-01 00:00:00

abstract：:In recent years, several synthetic cannabinoid compounds have become popular recreational drugs of abuse because of their psychoactive properties. This paper presents toxicological findings of synthetic cannabinoids in whole blood from some cases of severe intoxication including quantitative data from recreational use...

journal_title：Journal of analytical toxicology

authors： Kronstrand R,Roman M,Andersson M,Eklund A

更新日期：2013-10-01 00:00:00

abstract：:In an effort to determine a practical, efficient, and economical alternative for the use of a radioimmunoassay (RIA) for the detection of lysergic acid diethylamide (LSD) in human urine, the performance of two photometric immunoassays (Dade Behring EMIT II and Microgenics CEDIA) and the Diagnostics Products Corp. (DPC...

journal_title：Journal of analytical toxicology

authors： Wiegand RF,Klette KL,Stout PR,Gehlhausen JM

更新日期：2002-10-01 00:00:00

abstract：:A 59-year-old white male accidentally ingested a mouthful of a plant growth chemical, Cycocel, containing 11.8% of the active ingredient (2-chloroethyl)trimethylammonium chloride (chlormequat). He was seen by a family physician and then transferred to a hospital where he died as a result of ventricular fibrillation, w...

journal_title：Journal of analytical toxicology

authors： Winek CL,Wahba WW,Edelstein JM

更新日期：1990-07-01 00:00:00

abstract：:A method is described for the simultaneous determination of the ratio of l- and d-enantiomers of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxymethamphetamine (MDMA), and 3,4-methylenedioxyethylamphetamine (MDEA) in urine. The assay uses liquid-liquid extraction followed by deriv...

journal_title：Journal of analytical toxicology

authors： Hensley D,Cody JT

更新日期：1999-10-01 00:00:00

abstract：:In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a fast (15 min) comprehensive screening method for 500 toxicologically relevant analytes based on ultra-performance liquid chromatography (UPLC) coupled with a quadrupol...

journal_title：Journal of analytical toxicology

authors： Humbert L,Grisel F,Richeval C,Lhermitte M

更新日期：2010-11-01 00:00:00

abstract：:A sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitation of oxymorphone (OM) in human whole blood and liver. Sample preparation was done by solid-phase extraction, using deuterated OM as the internal standard. Separation was achieved using a Waters Aquity UPLC ...

journal_title：Journal of analytical toxicology

authors： Crum ED,Bailey KM,Richards-Waugh LL,Clay DJ,Gebhardt MA,Kraner JC

更新日期：2013-10-01 00:00:00

abstract：:An analytical procedure for the determination of the new pain medication tapentadol and its main metabolite N-desmethyltapentadol (DMT), in urine and oral fluid has been developed and validated using liquid chromatography with tandem mass spectral detection (LC-MS-MS). Oral fluid was collected using Quantisal™ devices...

journal_title：Journal of analytical toxicology

authors： Coulter C,Taruc M,Tuyay J,Moore C

更新日期：2010-10-01 00:00:00

abstract：:A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desmethyl-clomipramine and didesmethyl-clomipramine [DDCMI]), an...

journal_title：Journal of analytical toxicology

authors： Coudoré F,Hourcade F,Molinier-Manoukian C,Eschalier A,Lavarenne J

更新日期：1996-03-01 00:00:00

abstract：:Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control...

journal_title：Journal of analytical toxicology

authors： Desharnais B,Camirand-Lemyre F,Mireault P,Skinner CD

更新日期：2017-05-01 00:00:00

abstract：:To study the disposition kinetics of methamphetamine (MAP), we have developed a sensitive high-performance liquid chromatographic (HPLC) assay to quantitate the enantiomers of MAP and its major metabolites, amphetamine (AP), p-hydroxymethamphetamine (p-OH-MAP), and p-hydroxyamphetamine (p-OH-AP), the latter two of whi...

journal_title：Journal of analytical toxicology

authors： Sukbuntherng J,Hutchaleelaha A,Chow HH,Mayersohn M

更新日期：1995-05-01 00:00:00

abstract：:A rapid, simple, highly sensitive procedure for the simultaneous analysis of bromazepam, alprazolam, clonazepam, lorazepam, oxazepam, diazepam, midazolam, flurazepam, flunitrazepam, nordiazepam, triazolam, temazepam, nitrazepam, and chlordiazepoxide in oral fluid is described, using liquid chromatography coupled to a ...

journal_title：Journal of analytical toxicology

authors： Moore C,Coulter C,Crompton K,Zumwalt M

更新日期：2007-11-01 00:00:00

abstract：:The effects of decomposition microclimate on the distribution of dextromethorphan (DXM) and dextrorphan (DXT) in skeletonized remains of rats acutely exposed to DXM were examined. Animals (n = 10) received DXM (75 mg/kg, i.p.), were euthanized 30 min post-dose and immediately allowed to decompose at either Site A (sha...

journal_title：Journal of analytical toxicology

authors： Unger KA,Watterson JH

更新日期：2016-10-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:A simple isocratic HPLC procedure for the analysis of cocaine in plasma, with or without an internal standard, is described for the first time. Basified plasma was extracted in ether, re-extracted in acetic acid, which was subsequently basified prior to the final extraction in n-hexane. The hexane extract was evaporat...

journal_title：Journal of analytical toxicology

authors： Masoud AN,Krupski DM

更新日期：1980-11-01 00:00:00

abstract：:Two cases of overdose due to ingestion of trazodone are described. In one case, blood collected several hours following ingestion of an estimated 4 or more grams contained a trazodone concentration of 25.7 mg/L. Recovery was uneventful. The second case did not survive and death was attributed to the ingestion of multi...

journal_title：Journal of analytical toxicology

authors： Root I,Ohlson GB

更新日期：1984-03-01 00:00:00

abstract：:The purpose of this study was to develop and validate a gas chromatography-mass spectrometry method to detect drugs of abuse in a single sample of tooth. Pulverized samples of dental materials were subjected to acid hydrolysis to detect opiates, cocaine and their metabolites. The residual dental materials from these a...

journal_title：Journal of analytical toxicology

authors： Ottaviani G,Cameriere R,Cippitelli M,Froldi R,Tassoni G,Zampi M,Cingolani M

更新日期：2017-01-01 00:00:00

abstract：:With the increased availability of nitrite-containing commercial products that are used for the adulteration of urine samples in the workplace, it is necessary for laboratories to be able to detect and confirm the presence of nitrite in these samples. We have developed a method to confirm the presence of nitrite in ur...

journal_title：Journal of analytical toxicology

authors： Singh J,Elberling JA,Hemphill DG,Holmstrom J

更新日期：1999-05-01 00:00:00

abstract：:A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in o...

journal_title：Journal of analytical toxicology

authors： Bynum ND,Poklis JL,Gaffney-Kraft M,Garside D,Ropero-Miller JD

更新日期：2005-07-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is an endogenous androgenic steroid produced by the ovaries and adrenal glands. Research suggests that DHEA can be converted to testosterone in peripheral tissues. Classified as a nutritional supplement, this compound may be purchased without a prescription. The military and international...

journal_title：Journal of analytical toxicology

authors： Bosy TZ,Moore KA,Poklis A

更新日期：1998-10-01 00:00:00

abstract：:A high-performance liquid chromatographic method has been developed for the simultaneous analysis of eight frequently used benzodiazepines and some of their metabolites in postmortem samples. The method includes a liquid-liquid extraction with n-hexane-ethyl acetate (70:30, v/v), gradient elution of a C8 reversed-phas...

journal_title：Journal of analytical toxicology

authors： Lambert WE,Meyer E,Xue-Ping Y,De Leenheer AP

更新日期：1995-01-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:Analytical methods were developed to determine the presence of ethylenediaminetetraacetic acid (EDTA) in dried bloodstains to provide probative information when allegations of evidence tampering have been made in criminal cases. A simple screening method using ion chromatography to analyze stains was found to be quant...

journal_title：Journal of analytical toxicology

authors： Miller ML,McCord BR,Martz R,Budowle B

更新日期：1997-11-01 00:00:00