Gas chromatographic determination of urinary o-cresol for the monitoring of toluene exposure.

abstract：:An analytical method for determining exposure to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) has been enhanced. The method is based on the cleavage of adducted HD (protein-hydroxyethylthioethyl esters) to produce thiodiglycol. Following cleavage, a deuterated internal standard is added, and the analytes are extr...

journal_title：Journal of analytical toxicology

authors： Lawrence RJ,Smith JR,Boyd BL,Capacio BR

更新日期：2008-01-01 00:00:00

abstract：:A method for the simultaneous analysis of cocaine (COC), derivatized benzoylecgonine (BE), and derivatized ecgonine methyl ester (EME) has been developed. Blood or urine containing deuterated analogs of the three analytes is extracted by pouring over a Chem-Elut column and eluting with chloroform/isopropanol (9:1). Th...

journal_title：Journal of analytical toxicology

authors： Isenschmid DS,Levine BS,Caplan YH

更新日期：1988-09-01 00:00:00

abstract：:The objective of this project was to validate a new high-throughput homogeneous enzyme immunoassay (HEIA) for the rapid detection of carisoprodol in human urine. Carisoprodol (Soma(®)) and meprobamate are widely prescribed as musculoskeletal pain relief drugs and are listed as one of the 10 most frequently identified ...

journal_title：Journal of analytical toxicology

authors： Wang G,Huynh K,Barhate R,Rodrigues W,Moore C,Coulter C,Vincent M,Soares J

更新日期：2011-03-01 00:00:00

abstract：:A method for the detection and quantitation of methamphetamine and its major metabolite in hair, nails, sweat, and saliva from habitual users of methamphetamine by mass fragmentography has been developed. Hair and nail samples were washed with water and methanol to remove the external contamination, processed with 0.6...

journal_title：Journal of analytical toxicology

authors： Suzuki S,Inoue T,Hori H,Inayama S

更新日期：1989-05-01 00:00:00

abstract：:A fatal case attributed to flecainide intoxication is presented. Quantitation was by capillary gas chromatography with nitrogen-phosphorus detection. The flecainide concentration in the blood was 13 mg/L as compared to a therapeutic range in serum of 0.2-1.0 mg/L. Flecainide concentrations in other specimens were as f...

journal_title：Journal of analytical toxicology

authors： Levine B,Chute D,Caplan YH

更新日期：1990-09-01 00:00:00

abstract：:Positive benzoylecgonine (BZE) urinalysis results are sometimes challenged in legal and administrative proceedings on the grounds that the presence of BZE is due to the addition of cocaine to the urine sample with subsequent in vitro hydrolysis to BZE. Consequently, counsel for the respondent or defendant may move tha...

journal_title：Journal of analytical toxicology

authors： Klette KL,Poch GK,Czarny R,Lau CO

更新日期：2000-10-01 00:00:00

abstract：:We devised a highly sensitive method for simultaneously determining methamphetamine (MA) and amphetamine (AP) enantiomers, desmethylselegiline (DMSG) and selegiline (SG), in human hair using a derivatization technique and high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). M...

journal_title：Journal of analytical toxicology

authors： Nishida K,Itoh S,Inoue N,Kudo K,Ikeda N

更新日期：2006-05-01 00:00:00

abstract：:The aim of the present study was to assess the persistence of clenbuterol residues in retinal tissue of pigs after repeated administration in a growth-promoting dose, using enzyme-linked immunosorbent assay (ELISA) as a screening method for quantitative determination. A growth-promoting dose of clenbuterol (20 μg/kg b...

journal_title：Journal of analytical toxicology

authors： Pleadin J,Vulić A,Mitak M,Perši N,Milić D

更新日期：2011-01-01 00:00:00

abstract：:We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at p...

journal_title：Journal of analytical toxicology

authors： Guillot JG,Lefebvre M,Weber JP

更新日期：1997-03-01 00:00:00

abstract：:A new tetracyclic antidepressant drug, maprotiline hydrochloride was found to be the agent of death in a 23-year-old subject following massive injestion (4.5-6.0 g). The case may be the first reported maprotiline death (sole cause) in the United States. Analytical parameters were studies and various chromatographic an...

journal_title：Journal of analytical toxicology

authors： Rejent TA,Doyle RE

更新日期：1982-07-01 00:00:00

abstract：:Postmortem findings are presented for fourteen cases of Verapamil induced or related deaths. Liver, blood, and stomach concentrations of Verapamil alone or in combination with alcohol or other drugs are given with the age and sex of each victim and with the coroner's findings. The significance of these levels is discu...

journal_title：Journal of analytical toxicology

authors： Chan LF,Chhuy LH,Crowley RJ

更新日期：1987-07-01 00:00:00

abstract：:In clinical and forensic toxicology, general unknown screening is used to detect and identify exogenous compounds. In this study, we aimed to develop a fast (15 min) comprehensive screening method for 500 toxicologically relevant analytes based on ultra-performance liquid chromatography (UPLC) coupled with a quadrupol...

journal_title：Journal of analytical toxicology

authors： Humbert L,Grisel F,Richeval C,Lhermitte M

更新日期：2010-11-01 00:00:00

abstract：:An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...

journal_title：Journal of analytical toxicology

authors： Miki A,Tatsuno M,Katagi M,Nishikawa M,Tsuchihashi H

更新日期：2002-03-01 00:00:00

abstract：:This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Kintz P,Dubois N,Plomteux G

更新日期：2004-03-01 00:00:00

abstract：:The retention index system is a reproducible means for the identification of drugs in toxicology samples analyzed by gas chromatography with flame ionization detectors. Nitrogen-phosphorus (NP) detectors do not respond well to the standard n-alkanes, which lack nitrogen and phosphorus groups and which are used to obta...

journal_title：Journal of analytical toxicology

authors： Watts VW,Simonick TF

更新日期：1987-09-01 00:00:00

abstract：:A microextraction by packed sorbent (MEPS) procedure for rapid concentration of methadone and its primary metabolite (EDDP) in hair samples was developed. The miniaturized approach coupled to gas chromatography with tandem mass spectrometry (GC-MS-MS) was successfully validated. Hair samples (50 mg) were incubated wit...

journal_title：Journal of analytical toxicology

authors： Rosado T,Gallardo E,Vieira DN,Barroso M

更新日期：2020-12-12 00:00:00

abstract：:The aim of the present study was to develop and validate a method for the detection and quantitation of drugs of abuse in oral fluids. Fortified oral fluid samples (made in-house) and samples from donors collected with Quantasil oral fluid collection kits from Immunalysis were screened on an Olympus 5400 using reagent...

journal_title：Journal of analytical toxicology

authors： Kala SV,Harris SE,Freijo TD,Gerlich S

更新日期：2008-10-01 00:00:00

abstract：:A rapid, simple, highly sensitive procedure for the simultaneous analysis of bromazepam, alprazolam, clonazepam, lorazepam, oxazepam, diazepam, midazolam, flurazepam, flunitrazepam, nordiazepam, triazolam, temazepam, nitrazepam, and chlordiazepoxide in oral fluid is described, using liquid chromatography coupled to a ...

journal_title：Journal of analytical toxicology

authors： Moore C,Coulter C,Crompton K,Zumwalt M

更新日期：2007-11-01 00:00:00

abstract：:The popularity of designer drugs has increased over the past few years as users seek new, cheap and sometimes "legal" ways to get high. This case report focuses on a case that happened in the City of Henderson, Nevada, which involved the designer drug methoxetamine. Methoxetamine is a psychoactive compound that is str...

journal_title：Journal of analytical toxicology

authors： Fassette T,Martinez A

更新日期：2016-10-01 00:00:00

abstract：:A suicide caused by oral ingestion of colchicine is reported. Postmortem examination revealed circulating Pelger-Huet polymorphonuclear leukocytes and numerous mitotic and chromatin bodies in tissues with rapid cell turnover. Colchicine was identified by gas chromatography/mass spectrometry (GC/MS) of an organic extra...

journal_title：Journal of analytical toxicology

authors： Clevenger CV,August TF,Shaw LM

更新日期：1991-05-01 00:00:00

abstract：:Oral fluid (OF) is increasingly used for clinical, forensic and workplace drug testing as an alternative to urine. Uncertainties surrounding OF collection device performance, drug stability and testing reproducibility may be partially responsible for delays in the implementation of OF testing in regulated drug testing...

journal_title：Journal of analytical toxicology

authors： Samano KL,Anne L,Johnson T,Tang K,Sample RH

更新日期：2015-10-01 00:00:00

abstract：:An assay for neurotoxic esterase (neuropathy target esterase, NTE) was developed by Johnson (1,2) to assess the delayed neurotoxic potential of organophosphorus compounds. NTE activity is calculated from the rate of phenyl valerate hydrolysis resistant to paraoxon and sensitive to mipafox inhibition under specified co...

journal_title：Journal of analytical toxicology

authors： Kayyali US,Moore TB,Randall JC,Richardson RJ

更新日期：1991-03-01 00:00:00

abstract：:A protocol is described for the preparation and characterization of bovine blood lead (Pb) reference material (RM). Adult bovine animals are orally dosed with Pb as Pb(NO3)2, and blood is collected directly from the jugular vein into 5-mL evacuated, low-Pb glass tubes containing EDTA as anticoagulant. The blood is coo...

journal_title：Journal of analytical toxicology

authors： Cox DH,Duncan CE,Wyatt GP,Meadow JS,Robinson JB

更新日期：1989-07-01 00:00:00

abstract：:In order to achieve accurate quantitation of drugs and metabolites (analytes) in complex matrices, 2H- (and less commonly 13C-) labeled analogues of the analytes are now routinely adapted as the internal standards (IS) using linear calibration models to fit data generated by selected ion monitoring gas chromatography-...

journal_title：Journal of analytical toxicology

authors： Whiting TC,Liu RH,Chang WT,Bodapati MR

更新日期：2001-04-01 00:00:00

abstract：:The percent recovery of mercury from human hair digest samples, using the peak height cold-vapor atomic adsorption method is 73.0% +/- 10.3%. This value and its reproducibility are raised to 102.2% +/- 6.3% by use of peak area measurements in place of peak height. The so-called matrix effect is thus eliminated, and it...

journal_title：Journal of analytical toxicology

authors： Wigfield DC,Croteau SM,Perkins SL

更新日期：1981-01-01 00:00:00

abstract：:A modification of the Syva EMIT-tox Serum Barbiturate Assay was developed to provide a rapid and practical method for quantitating serum barbiturates. Standard curves for eight selected barbiturates were run using specific sets of standards for each. Correlation coefficients, slopes, and y-intercepts for the curves of...

journal_title：Journal of analytical toxicology

authors： Watson AT,Manno JE,Manno BR

更新日期：1983-11-01 00:00:00

abstract：:Bone was analyzed for ketamine and norketamine to examine whether different patterns of drug exposure could be discriminated. Rats received (intraperitoneally) one 75 mg/kg dose (Acute-1 and Acute-2 groups), three 25-mg/kg doses 1 hour apart (Repeated group), or nine single daily ketamine doses of 75 mg/kg followed by...

journal_title：Journal of analytical toxicology

authors： Watterson JH,Donohue JP,Betit CC

更新日期：2012-07-01 00:00:00

abstract：:Sixteen apparently intact procainamide tablets, in varied stages of drug depletion, were found distributed throughout the gastrointestinal tract of a man who died of arteriosclerotic heart disease with pulmonary complications. The tablets were found to contain procainamide by a thin layer chromatography system with ca...

journal_title：Journal of analytical toxicology

authors： Griesemer EC

更新日期：1984-09-01 00:00:00

abstract：:A gas-chromatographic analysis of vinylidene chloride (1,1-dichloroethylene) is presented. Vinylidene chloride was sampled by adsorbing on activated carbon. It was desorbed with carbon disulfide. The desorption efficiency was 97.2 +/- 1.05 (mean +/- standard error). The analytical column was packed with 10% Apiezon L ...

journal_title：Journal of analytical toxicology

authors： Sidhu KS

更新日期：1980-09-01 00:00:00

abstract：:In an effort to determine a practical, efficient, and economical alternative for the use of a radioimmunoassay (RIA) for the detection of lysergic acid diethylamide (LSD) in human urine, the performance of two photometric immunoassays (Dade Behring EMIT II and Microgenics CEDIA) and the Diagnostics Products Corp. (DPC...

journal_title：Journal of analytical toxicology

authors： Wiegand RF,Klette KL,Stout PR,Gehlhausen JM

更新日期：2002-10-01 00:00:00