Pretreatment of urine samples for the analysis of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid using solid-phase extraction.

abstract：:There has been a recent and significant increase in the use and availability of hemp seed oil products. These products are being marketed as a healthy source of essential omega fatty acids when taken orally. Although the health aspects of these oils is open to debate, the probability that oils derived from the hemp se...

journal_title：Journal of analytical toxicology

authors： Bosy TZ,Cole KA

更新日期：2000-10-01 00:00:00

abstract：:Radioactive methadone, phenytoin, phenobarbital, and diazepam were easily and efficiently removed from human urine samples by adsorption on C18 bonded silica phases. These techniques were simpler than conventional extractions at pH 9.3 or 5.2 with dichloromethane, XAD-2 and methanol, or Celite 560 and dichloromethane....

journal_title：Journal of analytical toxicology

authors： Hyde PM

更新日期：1985-11-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA), or ecstasy, is excreted as unchanged drug, 3,4-methylenedioxyamphetamine (MDA), and free and glucuronidated/sulfated 4-hydroxy-3-methoxymethamphetamine (HMMA), and 4-hydroxy-3-methoxyamphetamine (HMA) metabolites. The aim of this paper is to describe the pattern and timeframe ...

journal_title：Journal of analytical toxicology

authors： Abraham TT,Barnes AJ,Lowe RH,Kolbrich Spargo EA,Milman G,Pirnay SO,Gorelick DA,Goodwin RS,Huestis MA

更新日期：2009-10-01 00:00:00

abstract：:Improvements have been made in recent years in on-site or point-of-care (POC) immunoassay testing devices. We evaluated the DrugCheck 9 cup, a new qualitative visually read, competitive binding, immunoassay cup that measures nine analytes. The study was performed according to the recent National Laboratory Certificati...

journal_title：Journal of analytical toxicology

authors： Taylor EH,Pizzo P

更新日期：2004-04-01 00:00:00

abstract：:Sterile whole human blood control materials were commercially prepared in batches containing anticoagulants and preservatives and approximately 90, 150, and 230 mg/dL ethanol with and without 0.3% (w/v) sodium azide. Aliquots in sealed vials were stored by the manufacturer at 2-8 degrees C until shipped monthly to thr...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Gadsden RH Sr,Poklis A

更新日期：1997-10-01 00:00:00

abstract：INTRODUCTION:We encountered unexpected false positive urine results in three patients for amphetamine-type substances by immunoassay, measured as part of community drug prevention programmes. Kavain was identified in all three urine samples by gas chromatography mass spectrometry (GC-MS). No other potential cross-react...

journal_title：Journal of analytical toxicology

authors： Madhavaram H,Patel T,Kyle C

更新日期：2020-12-16 00:00:00

abstract：:Cyanohydrins, also be called cyanoalcohols, are important industrial precursors to carboxylic acids and some amino acids. Acetone cyanohydrin (ACH) and formaldehyde cyanohydrin (glycolonitrile, FCH), which are the typical examples of cyanohydrins, are classified as extremely hazardous substances. As the cyanohydrins c...

journal_title：Journal of analytical toxicology

authors： Zheng S,Yuan X,Wang W,Liang C,Cao F,Zhang R

更新日期：2016-06-01 00:00:00

abstract：:The purpose of this study was to develop and validate a gas chromatography-mass spectrometry method to detect drugs of abuse in a single sample of tooth. Pulverized samples of dental materials were subjected to acid hydrolysis to detect opiates, cocaine and their metabolites. The residual dental materials from these a...

journal_title：Journal of analytical toxicology

authors： Ottaviani G,Cameriere R,Cippitelli M,Froldi R,Tassoni G,Zampi M,Cingolani M

更新日期：2017-01-01 00:00:00

abstract：:A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid extraction, followed by solid-phase extraction, and separation on an HP5 Trace column. Ionization mode was electronic ...

journal_title：Journal of analytical toxicology

authors： Charlier C,Dubois N,Cucchiaro S,Plomteux G

更新日期：2003-03-01 00:00:00

abstract：:The measurement of cefoperazone concentrations in cerebral spinal fluid (CSF) is important to understanding the biodisposition and pharmacokinetic behavior of the drug. We have demonstrated that cefoperazone is unstable in methanol and at alkaline pH and these factors may affect the accurate quantitation of the drug i...

journal_title：Journal of analytical toxicology

authors： Kinniburgh DW,Jennison TA,Matsen JM

更新日期：1982-03-01 00:00:00

abstract：:Methods for extraction of cocaine, some of its metabolites, morphine, and codeine from hair and methods for analyzing the extracts have been investigated. Results of these studies have shown that extractions with 0.1N HCl are efficient at removing the target compounds from hair and appear to be as effective as enzymat...

journal_title：Journal of analytical toxicology

authors： Welch MJ,Sniegoski LT,Allgood CC,Habram M

更新日期：1993-11-01 00:00:00

abstract：:During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at ...

journal_title：Journal of analytical toxicology

authors： Paul BD,Past MR,McKinley RM,Foreman JD,McWhorter LK,Snyder JJ

更新日期：1994-10-01 00:00:00

abstract：:A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in o...

journal_title：Journal of analytical toxicology

authors： Bynum ND,Poklis JL,Gaffney-Kraft M,Garside D,Ropero-Miller JD

更新日期：2005-07-01 00:00:00

abstract：:This article reports the investigation by 1H nuclear magnetic resonance (1H NMR) spectroscopy of biological fluids in a case of intentional poisoning with tetrahydrofuran (THF). Occupational exposures to this solvent are well documented, but acute poisoning cases are extremely rare, and the one presented here is the s...

journal_title：Journal of analytical toxicology

authors： Cartigny B,Azaroual N,Imbenotte M,Sadeg N,Testart F,Richecoeur J,Vermeersch G,Lhermitte M

更新日期：2001-05-01 00:00:00

abstract：:New psychoactive substances (NPS) are a major public health problem, primarily due to the increased number of acute poisoning cases. Detection of these substances is a challenge. The aim of this research was to develop and validate a sensitive screening method for 104 drugs of abuse, including synthetic cannabinoids, ...

journal_title：Journal of analytical toxicology

authors： da Cunha KF,Oliveira KD,Huestis MA,Costa JL

更新日期：2020-10-12 00:00:00

abstract：:Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolic hydrolysis, extraction procedures were developed for the efficient recovery of heroin, 6-acetylmorphine, and morphine fro...

journal_title：Journal of analytical toxicology

authors： Goldberger BA,Cone EJ,Grant TM,Caplan YH,Levine BS,Smialek JE

更新日期：1994-01-01 00:00:00

abstract：:British anti-Lewisite (BAL) (2,3-dimercapto-1-propanol) is a potential therapeutic compound when used against the effects of cutaneous sulfur mustard, and a method for its determination in plasma has been developed. BAL and the internal standard (IS) ethane dithiol were isolated from plasma samples through solid-phase...

journal_title：Journal of analytical toxicology

authors： Byers CE,Holloway ER,Korte WD,Smith JR,Clarkson ED,Platoff GE,Capacio BR

更新日期：2004-07-01 00:00:00

abstract：:A variety of chemical agents were evaluated to determine their effects on fluorescence polarization immunoassays for drugs of abuse. Sixteen different agents, at concentrations up to 10%, were tested against urine assays for cannabinoids, cocaine (metabolite), amphetamines, opiates, phencyclidine (PCP), and barbiturat...

journal_title：Journal of analytical toxicology

authors： Schwarzhoff R,Cody JT

更新日期：1993-01-01 00:00:00

abstract：:Oxymorphone (OM), a prescription opioid and metabolite of oxycodone, was included in the recently published proposed revisions to the Mandatory Guidelines for Federal Workplace Drug Testing Programs. To facilitate toxicological interpretation, this study characterized the time course of OM and its metabolite, noroxymo...

journal_title：Journal of analytical toxicology

authors： DePriest AZ,Heltsley R,Black DL,Mitchell JM,LoDico C,Flegel R,Cone EJ

更新日期：2016-10-01 00:00:00

abstract：:Calibration model selection is required for all quantitative methods in toxicology and more broadly in bioanalysis. This typically involves selecting the equation order (quadratic or linear) and weighting factor correctly modelizing the data. A mis-selection of the calibration model will generate lower quality control...

journal_title：Journal of analytical toxicology

authors： Desharnais B,Camirand-Lemyre F,Mireault P,Skinner CD

更新日期：2017-05-01 00:00:00

abstract：:A new tetracyclic antidepressant drug, maprotiline hydrochloride was found to be the agent of death in a 23-year-old subject following massive injestion (4.5-6.0 g). The case may be the first reported maprotiline death (sole cause) in the United States. Analytical parameters were studies and various chromatographic an...

journal_title：Journal of analytical toxicology

authors： Rejent TA,Doyle RE

更新日期：1982-07-01 00:00:00

abstract：:Bleach, nitrite, chromate, and hydrogen peroxide-peroxidase are effective urine adulterants used by the illicit drug users to conceal marijuana-positive results. Methods for detecting nitrite and chromate are available. Effects of other oxidizing agents that could possibly be used as adulterants and are difficult to d...

journal_title：Journal of analytical toxicology

authors： Paul BD,Jacobs A

更新日期：2002-10-01 00:00:00

abstract：:The metabolism of N-benzylpiperazine (BZP), a recently scheduled designer drug, in the rat has been studied by analyzing its urinary metabolites. p-Hydroxy-BZP (p-OH-BZP) was unequivocally identified as the main metabolite along with a minor metabolite m-hydroxy-BZP (m-OH-BZP), using gas chromatography-mass spectromet...

journal_title：Journal of analytical toxicology

authors： Tsutsumi H,Katagi M,Miki A,Shima N,Kamata T,Nakajima K,Inoue H,Kishi T,Tsuchihashi H

更新日期：2006-01-01 00:00:00

abstract：:Selegiline (SE) is a selective, irreversible monoamine oxidase-B inhibitor, used for reducing symptoms in early-stage Parkinson's disease. The metabolites of SE include l-methamphetamine, l-amphetamine and desmethylselegiline (DSE). The stereoisomers of SE metabolites, d-methamphetamine and d-amphetamine are highly ad...

journal_title：Journal of analytical toxicology

authors： Shin I,Choi H,Kang S,Kim J,Park Y,Yang W

更新日期：2020-05-30 00:00:00

abstract：:Sulfur mustard (SM) is a chemical warfare agent that causes painful blisters and chemically modifies endogenous biomacromolecules by alkylation to hydroxyethylthioethyl (HETE) adducts representing valuable long-term markers for post-exposure analysis. The albumin adduct formed in human plasma in vitro (HETE bound to t...

journal_title：Journal of analytical toxicology

authors： Gandor F,Gawlik M,Thiermann H,John H

更新日期：2015-05-01 00:00:00

abstract：:The method presented describes a sensitive and specific quantitative assay for the determination of flumazenil in human plasma. Flumazenil and an internal standard, midazolam, are isolated by a basic extraction. The final extract is separated on a 25-m BP-1 capillary column and drugs are detected by selected ion monit...

journal_title：Journal of analytical toxicology

authors： Kintz P,Mangin P

更新日期：1991-07-01 00:00:00

abstract：:Urine drug testing is common for workplace drug testing, prescription management, emergency medicine and the criminal justice system. Unsurprisingly, with the significant consequences based upon the results of urine drug testing, a donor in need of concealing the contents of their sample is highly motivated to cheat t...

journal_title：Journal of analytical toxicology

authors： Goggin MM,Tann CM,Miller A,Nguyen A,Janis GC

更新日期：2017-03-01 00:00:00

abstract：:The collection and analysis of drugs in oral fluid (OF) at the roadside has become more feasible with the introduction of portable testing devices such as the Alere™ DDS®2 Mobile Test System (DDS®2). The objective of this study was to compare the on-site results for the DDS®2 to laboratory-based confirmatory assays wi...

journal_title：Journal of analytical toxicology

authors： Krotulski AJ,Mohr ALA,Friscia M,Logan BK

更新日期：2018-04-01 00:00:00

abstract：:In cases of death by inert gas asphyxiation, it can be difficult to obtain toxicological evidence supporting assignment of a cause of death. Because of its low mass and high diffusivity, and its common use as a carrier gas, helium presents a particular challenge in this respect. We describe a rapid and simple gas chro...

journal_title：Journal of analytical toxicology

authors： Schaff JE,Karas RP,Marinetti L

更新日期：2012-03-01 00:00:00

abstract：:A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...

journal_title：Journal of analytical toxicology

authors： Gaudette NF,Lodge JW

更新日期：2005-01-01 00:00:00