Plasma determination of flumazenil, a benzodiazepine antagonist, by immunotoxicology and by capillary gas chromatography/mass spectrometry.

abstract：:Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable. Consequently, most laboratories employ liquid chromatography-tandem mass spectrometry (LC-MS-MS) screening, which can be complex ...

journal_title：Journal of analytical toxicology

authors： Neifeld JR,Regester LE,Holler JM,Vorce SP,Magluilo J Jr,Ramos G,Bosy TZ

更新日期：2016-06-01 00:00:00

abstract：:3,4-Methylenedioxypyrovalerone (MDPV) is a psychoactive, synthetic analog of the central nervous system stimulant cathinone. Its recent popularity as a recreational drug in the United States has led to numerous reports to poison control centers across the country. As with other synthetic cathinones, the recreational u...

journal_title：Journal of analytical toxicology

authors： Wyman JF,Lavins ES,Engelhart D,Armstrong EJ,Snell KD,Boggs PD,Taylor SM,Norris RN,Miller FP

更新日期：2013-04-01 00:00:00

abstract：:This study describes a matrix-assisted laser-desorption-ionization (MALDI) mass spectrometry for rapid screening of 12 diuretics in spiked urine. C60 is used as the matrix for MALDI. Diuretics are directly analyzed by C60-MALDI without previous derivatization. The fact that most diuretic molecules contain sulfate grou...

journal_title：Journal of analytical toxicology

authors： Huang JP,Yuan CH,Shiea J,Chen YC

更新日期：1999-09-01 00:00:00

abstract：:Although many deaths occur annually from heroin intoxication, the presence of heroin has not been reported in postmortem tissues. Recognizing heroin's susceptibility to rapid chemical and metabolic hydrolysis, extraction procedures were developed for the efficient recovery of heroin, 6-acetylmorphine, and morphine fro...

journal_title：Journal of analytical toxicology

authors： Goldberger BA,Cone EJ,Grant TM,Caplan YH,Levine BS,Smialek JE

更新日期：1994-01-01 00:00:00

abstract：:A new method was developed to apply the advantages of automated gas chromatographic headspace analysis to delayed measurement of alcohol in whole breath (W-B). End-expiratory breath and vapor-alcohol samples were collected in sealed, heated 22-mL glass vials, stored for 0-15 days, and thereafter analyzed for alcohol b...

journal_title：Journal of analytical toxicology

authors： Dubowski KM,Essary NA

更新日期：1982-09-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI), a still-emerging, non-invasive neuroimaging tool, has been applied to a wide range of questions in sensory, motor control, and cognitive psychology. Only more recently has it been applied to understand the sites and mechanisms of action of pharmacological agents within the...

journal_title：Journal of analytical toxicology

authors： Stein EA

更新日期：2001-07-01 00:00:00

abstract：:A quantitative analysis was developed for the determination of cocaine, benzoylecgonine, and cocaethylene in oral fluid using liquid chromatography-tandem mass spectrometry. After internal standardization and solid-phase extraction, chromatographic separation was achieved on a reversed-phase column by gradient elution...

journal_title：Journal of analytical toxicology

authors： Clauwaert K,Decaestecker T,Mortier K,Lambert W,Deforce D,Van Peteghem C,Van Bocxlaer J

更新日期：2004-11-01 00:00:00

abstract：:A fatality due to the ingestion of isoniazid, a tuberculostatic agent, is presented. Isoniazid was extracted by a single step extraction procedure, derivatized with trifluoroacetic anhydride, and identified and quantified by gas chromatography/mass spectrometry (GC/MS). The distribution of isoniazid was as follows: he...

journal_title：Journal of analytical toxicology

authors： LoDico CP,Levine BS,Goldberger BA,Caplan YH

更新日期：1992-01-01 00:00:00

abstract：:High doses of nutmeg (seeds from Myristica fragrans Houtt.) can be abused as a psychoactive drug due to phenylpropene ingredients. During controlled abstinence, e.g., in forensic psychiatric clinics, nutmeg abuse has to be distinguished from an ingestion of other spices having phenylpropene ingredients (e.g., black pe...

journal_title：Journal of analytical toxicology

authors： Neukamm MA,Schwelm HM,Vieser S,Schiesel N,Auwärter V

更新日期：2020-01-07 00:00:00

abstract：:The opioids codeine and morphine have legitimate uses in managing chronic pain conditions, but they are frequently abused. Patients prescribed opioids submit urine samples for medication compliance monitoring, and the interpretation of the results is complex. The purpose of this study was to evaluate the percentage of...

journal_title：Journal of analytical toxicology

authors： Colby JM,Wu AH,Lynch KL

更新日期：2015-06-01 00:00:00

abstract：:A new point-of-care colloidal metal immunoassay urine drugs-of-abuse testing device, the BIOSITE TRIAGE Plus Propoxyphene (TPP), was evaluated for the rapid detection of dextropropoxyphene (PPY) and/or its primary metabolite, norpropoxyphene (NP), in urine at a total PPY/NP concentration of 300 ng/mL or greater. This ...

journal_title：Journal of analytical toxicology

authors： Poklis A,Poklis JL,Tarnai LD,Backer RC

更新日期：2004-09-01 00:00:00

abstract：:Buprenorphine, which is used in France as a substitution drug for opioid addiction, is widely abused, and several fatal cases have been reported. In order to confirm a recent intoxication or to establish retrospectively chronic abuse, a simple and reliable gas chromatographic-mass spectrometric method was developed an...

journal_title：Journal of analytical toxicology

authors： Vincent F,Bessard J,Vacheron J,Mallaret M,Bessard G

更新日期：1999-07-01 00:00:00

abstract：:Quantitative analysis of Δ9-tetrahydrocannabinol (Δ9-THC) in oral fluid has gained increasing interest in clinical and forensic toxicology laboratories. New medicinal and/or recreational cannabinoid products require laboratories to distinguish different patterns of cannabinoid use. This study validated a high-performa...

journal_title：Journal of analytical toxicology

authors： Lin L,Amaratunga P,Reed J,Huang P,Lemberg BL,Lemberg D

更新日期：2020-12-03 00:00:00

abstract：:The content, chemical form, and distribution of mercury and selenium in edible tissue were determined for several samples of fish and other marine animal organisms (mollusks, crustaceans and pods). For most fish samples, except Pacific blue marlin, 53 to 94% of the total mercury content was present as methylmercury, b...

journal_title：Journal of analytical toxicology

authors： Cappon CJ,Smith JC

更新日期：1982-01-01 00:00:00

abstract：:A method for determining the chemical warfare agent soman (GD) in rat plasma has been validated and applied to low-level inhalation exposure studies currently being conducted. This method utilizes a fluoride ion-based regeneration assay with isotope dilution followed by large volume injection gas chromatography with a...

journal_title：Journal of analytical toxicology

authors： Renner JA,Dabisch PA,Evans RA,McGuire JM,Totura AL,Jakubowski EM,Thomson SA

更新日期：2008-01-01 00:00:00

abstract：:Drug-facilitated sexual assault (DFSA) cases are pretty common in forensic toxicology. In this case report, a 56-year-old female tourist claimed to have been sexually assaulted by five men after having had a drug-spiked alcoholic drink. Urine samples were collected at 38, 44, and 45 hours after the alleged rape. After...

journal_title：Journal of analytical toxicology

authors： Carfora A,Campobasso CP,Cassandro P,Petrella R,Borriello R

更新日期：2020-11-12 00:00:00

abstract：:Six cases involving the antidepressant mirtazapine were analyzed in detail at the San Diego County Medical Examiner's Office from 2004 to 2005. Mirtazapine was initially detected and confirmed in each of these cases by a liquid-liquid gas chromatography (GC)-MS basic drug screen. Following another liquid-liquid basic ...

journal_title：Journal of analytical toxicology

authors： Kirkton C,McIntyre IM

更新日期：2006-11-01 00:00:00

abstract：:Human exposure to organophosphate pesticides can be estimated from the presence of urinary metabolites. An isotope-dilution gas chromatography-tandem mass spectrometry (GC-MS-MS) method was developed for quantitating the six dialkyl phosphate urinary metabolites of at least 29 organophosphate pesticides. Urine samples...

journal_title：Journal of analytical toxicology

authors： Bravo R,Driskell WJ,Whitehead RD Jr,Needham LL,Barr DB

更新日期：2002-07-01 00:00:00

abstract：:Analytical chemical procedures are described to determine residues of the drugs clofibrate and tibric acid in animal feed, wastewater, and human urine. Clofibrate was extracted from animal feed and human urine with hexane, whereas residues from wastewater were collected on a Sep-PakTM then eluted with methanol for ana...

journal_title：Journal of analytical toxicology

authors： Oller WL,Kendall DC,Bowman MC

更新日期：1982-07-01 00:00:00

abstract：:The quantification of drugs of abuse in keratinized matrices is becoming of special relevance for monitoring consumption and for post-mortem investigations. We aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone (MET), 2-ethylidene-1,5-dime...

journal_title：Journal of analytical toxicology

authors： Magalhães TP,Cravo S,Silva DDD,Dinis-Oliveira RJ,Afonso C,Lourdes Bastos M,Carmo H

更新日期：2018-04-01 00:00:00

abstract：:Methoxyacetylfentanyl and cyclopropylfentanyl are two of the newest illicit opioids that are infiltrating the heroin market. Methoxyacetylfentanyl and cyclopropylfentanyl were reported by the Drug Enforcement Administration (DEA) in their third quarter report of 2017 to have been chemically identified seven and five t...

journal_title：Journal of analytical toxicology

authors： Fogarty MF,Papsun DM,Logan BK

更新日期：2018-11-01 00:00:00

abstract：:cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL,...

journal_title：Journal of analytical toxicology

authors： Rop PP

更新日期：2001-07-01 00:00:00

abstract：:A high performance liquid chromatographic method is described for the simultaneous quantitation of four commonly prescribed antiarrhythmic drugs: lidocaine, mexiletine, disopyramide, and quinidine. An isocratic system using a reverse phase column was used to separate these compounds. Coefficients of variation were les...

journal_title：Journal of analytical toxicology

authors： Dusci LJ,Hackett LP

更新日期：1985-03-01 00:00:00

abstract：:Analysis of drugs in hair differs from their analysis in other tissues due to the extended detection window, as well as the opportunity that segmental hair analysis offers for the detection of changes in drug intake over time. The antipsychotic drug chlorprothixene is widely used, but few reports exist on chlorprothix...

journal_title：Journal of analytical toxicology

authors： Günther KN,Johansen SS,Wicktor P,Banner J,Linnet K

更新日期：2018-11-01 00:00:00

abstract：:Pigmented (C57BI) and nonpigmented (balb/c) mice, 25 days of age, were treated intraperitoneally with [3H]-nicotine (4 mg/kg, 555 dpm/ng) or [3H]-flunitrazepam (1 mg/kg, 2200 dpm/ng) daily for three days. After 21 days, shaved back hair was digested at 37 degrees C for 24 h with either 1 M sodium hydroxide or 1 M sodi...

journal_title：Journal of analytical toxicology

authors： Claffey DJ,Stout PR,Ruth JA

更新日期：2000-01-01 00:00:00

abstract：:Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methy...

journal_title：Journal of analytical toxicology

authors： Shin HS,Park BB,Choi SN,Oh JJ,Hong CP,Ryu H

更新日期：1998-01-01 00:00:00

abstract：:An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram. ...

journal_title：Journal of analytical toxicology

authors： Bednarczyk LR,Matusiak W

更新日期：1982-09-01 00:00:00

abstract：:The effects of decomposition microclimate on the distribution of dextromethorphan (DXM) and dextrorphan (DXT) in skeletonized remains of rats acutely exposed to DXM were examined. Animals (n = 10) received DXM (75 mg/kg, i.p.), were euthanized 30 min post-dose and immediately allowed to decompose at either Site A (sha...

journal_title：Journal of analytical toxicology

authors： Unger KA,Watterson JH

更新日期：2016-10-01 00:00:00

abstract：:The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...

journal_title：Journal of analytical toxicology

authors： Sokoro A,Lehotay D,Eichhorst J,Treble R

更新日期：2007-07-01 00:00:00

abstract：:A 69-year-old male radio technician drank an unknown amount of a liquid and died within 5 h at a hospital. Mainly silver, potassium, and calcium, among other substances, were found in the residue of the liquid from the empty bottle by means of the spectrographic method (30.7% silver and 25.5% potassium using atomic ab...

journal_title：Journal of analytical toxicology

authors： Lech T

更新日期：1997-11-01 00:00:00