Quantitative analysis of benzene by selected ion monitoring/gas chromatography/mass spectrometry.

abstract：:The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods ...

journal_title：Journal of analytical toxicology

authors： Ellerbe P,Long T,Welch MJ

更新日期：1993-05-01 00:00:00

abstract：:A sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantitation of oxymorphone (OM) in human whole blood and liver. Sample preparation was done by solid-phase extraction, using deuterated OM as the internal standard. Separation was achieved using a Waters Aquity UPLC ...

journal_title：Journal of analytical toxicology

authors： Crum ED,Bailey KM,Richards-Waugh LL,Clay DJ,Gebhardt MA,Kraner JC

更新日期：2013-10-01 00:00:00

abstract：:Ethylene glycol (EG), a relatively infrequent cause of fatal intoxication, presents an analytical challenge for forensic confirmation in postmortem toxicology. We report EG and glycolic acid (GA) quantification in postmortem blood by gas chromatography coupled with ion trap mass spectrometry (GC-MS) analysis using a m...

journal_title：Journal of analytical toxicology

authors： Rosano TG,Swift TA,Kranick CJ,Sikirica M

更新日期：2009-10-01 00:00:00

abstract：:A sensitive and reproducible gas chromatographic procedure for the quantitative determination of urinary o-cresol is described. The first step involves acid hydrolysis (2N HCl, 100 degrees C, 10 min), which yields unconjugated o-cresol. After extraction (methylene chloride, pH 2), the organic layer is concentrated by ...

journal_title：Journal of analytical toxicology

authors： Truchon G,Tardif R,Brodeur J

更新日期：1996-09-01 00:00:00

abstract：:Salicylate excretion was studied in the breast milk of a nursing mother (Patient A) taking chronic therapeutic doses of aspirin, and caffeine excretion was monitored in the breast milk of a nursing mother (Patient B) who was a heavy coffee drinker. Salicylate concentrations were maximal in serum at 2.25 hours (10.8 mg...

journal_title：Journal of analytical toxicology

authors： Bailey DN,Weibert RT,Naylor AJ,Shaw RF

更新日期：1982-03-01 00:00:00

abstract：:A method is presented for the extraction and screening of basic and neutral drugs, including amphetamines. Two milliliters of blood are buffered to pH 9.0 and extracted with n-chlorobutane. Underivatized extracts are analyzed simultaneously on two complementary capillary columns placed together in one injection port u...

journal_title：Journal of analytical toxicology

authors： Watts VW,Simonick TF

更新日期：1986-09-01 00:00:00

abstract：:A simple and efficient method, based on the adsorption properties of octadecasilane bonded silica, is described for the rapid extraction of acidic drugs from whole post mortem blood. The blood was diluted, passed through an extraction column containing the bonded silica and the absorbed drugs were eluted with methanol...

journal_title：Journal of analytical toxicology

authors： Ford B,Vine J,Watson TR

更新日期：1983-05-01 00:00:00

abstract：:This paper describes two relatively simple methods for the microdetermination of urinary cadmium (U-Cd) and urinary nickel (U-Ni) using electrothermal atomic absorption spectrometry. Reduction of nonspecific absorption interferences was achieved by temperature programming and background correction using a deuterium ar...

journal_title：Journal of analytical toxicology

authors： Ong CN,Chua LH,Lee BL,Ong HY,Chia KS

更新日期：1990-01-01 00:00:00

abstract：:The method presented describes a sensitive and specific quantitative assay for the determination of flumazenil in human plasma. Flumazenil and an internal standard, midazolam, are isolated by a basic extraction. The final extract is separated on a 25-m BP-1 capillary column and drugs are detected by selected ion monit...

journal_title：Journal of analytical toxicology

authors： Kintz P,Mangin P

更新日期：1991-07-01 00:00:00

abstract：:Unknown compounds that were not amenable to GC/MS were found during routine benzodiazepine HPLC screening in a postmortem case. The apparent thermolability made the application of liquid chromatography with mass spectrometry mandatory. The moving-belt interface was used because of its value for identification based on...

journal_title：Journal of analytical toxicology

authors： Verheij ER,van der Greef J,La Vos GF,van der Pol W,Niessen WM

更新日期：1989-01-01 00:00:00

abstract：:A protocol is described for the preparation and characterization of bovine blood lead (Pb) reference material (RM). Adult bovine animals are orally dosed with Pb as Pb(NO3)2, and blood is collected directly from the jugular vein into 5-mL evacuated, low-Pb glass tubes containing EDTA as anticoagulant. The blood is coo...

journal_title：Journal of analytical toxicology

authors： Cox DH,Duncan CE,Wyatt GP,Meadow JS,Robinson JB

更新日期：1989-07-01 00:00:00

abstract：:Given that external contamination must be considered in hair analysis, there is still a demand for reliable tools to differentiate between incorporation of drugs into the hair as a result of drug consumption and of the hair shaft by external contamination. With the aim of establishing alternative discrimination parame...

journal_title：Journal of analytical toxicology

authors： Scholz C,Quednow BB,Herdener M,Kraemer T,Baumgartner MR

更新日期：2019-08-23 00:00:00

abstract：:Prolintane is a sympathomimetic amine with pharmacologic properties similar to d-amphetamine. Side effects include insomnia, nervousness, and irritability. Overdoses of prolintane may cause hallucinations, psychosis, and death. The drug is commonly prescribed in Africa, Australia, and Europe but is not available in th...

journal_title：Journal of analytical toxicology

authors： Kyle PB,Daley WP

更新日期：2007-09-01 00:00:00

abstract：:In previous experimental studies on heroin metabolites excretion in urine, the first sample was often collected a few hours after intake. In forensic cases, it is sometimes questioned if a positive urine result is expected e.g., 30 min after intake. The aim of this study was to investigate urinary excretion of heroin ...

journal_title：Journal of analytical toxicology

authors： Høiseth G,Gottås A,Berg T,Arnestad M,Halvorsen PS,Bachs LC

更新日期：2017-06-01 00:00:00

abstract：:Cyclopropylfentanyl is a fentanyl analog implicated in 78 deaths in Europe and over 100 deaths in the United States, but toxicological information including metabolism data about this drug is scarce. The aim of this study was to provide the exact structure of abundant and unique metabolites of cyclopropylfentanyl alon...

journal_title：Journal of analytical toxicology

authors： Vikingsson S,Rautio T,Wallgren J,Åstrand A,Watanabe S,Dahlén J,Wohlfarth A,Konradsson P,Wu X,Kronstrand R,Gréen H

更新日期：2019-09-10 00:00:00

abstract：:With the increased availability of nitrite-containing commercial products that are used for the adulteration of urine samples in the workplace, it is necessary for laboratories to be able to detect and confirm the presence of nitrite in these samples. We have developed a method to confirm the presence of nitrite in ur...

journal_title：Journal of analytical toxicology

authors： Singh J,Elberling JA,Hemphill DG,Holmstrom J

更新日期：1999-05-01 00:00:00

abstract：:A rapid and sensitive assay for pyridinium oximes in plasma and tissue was developed. The method was suitable for the analysis of mono- and di-pyridinium oximes and utilizes ultrafiltration followed by cation-exchange high-performance liquid chromatography with UV detection. The assay was originally developed for the ...

journal_title：Journal of analytical toxicology

authors： Singh H,Moorad-Doctor D,Ratcliffe RH,Wachtel K,Castillo A,Garcia GE

更新日期：2007-03-01 00:00:00

abstract：:This manuscript reviews data available in the scientific literature relative to drug testing for the five mandated drug classes and circumstances other than abuse of the drug itself that could result in a positive test. For marijuana, passive inhalation, unknowing oral ingestion, and the use of Marinol are discussed. ...

journal_title：Journal of analytical toxicology

authors： elSohly MA,Jones AB

更新日期：1995-10-01 00:00:00

abstract：:An automated solid-phase extraction (SPE) protocol followed by gas chromatography coupled with tandem mass spectrometry was developed for quantification of caffeine, cyamemazine, meprobamate, morphine and 6-monoacetylmorphine (6-MAM) in 11 biological matrices [blood, urine, bile, vitreous humor, liver, kidney, lung an...

journal_title：Journal of analytical toxicology

authors： Bévalot F,Bottinelli C,Cartiser N,Fanton L,Guitton J

更新日期：2014-06-01 00:00:00

abstract：:The post mortem findings of pentazocine and tripelennamine ("T's and Blues") in abusers dying in the City of St. Louis between July 1, 1979 and July 30, 1981 are presented. Thirty-three deaths were homicides; 30 black males, ages 21-38; one white male, age 26, died from gunshot wounds; and two black females, age 18 an...

journal_title：Journal of analytical toxicology

authors： Poklis A,Mackell MA

更新日期：1982-05-01 00:00:00

abstract：:A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exch...

journal_title：Journal of analytical toxicology

authors： Martin R,Schürenkamp J,Gasse A,Pfeiffer H,Köhler H

更新日期：2015-03-01 00:00:00

abstract：:Hydrocodone in combination with acetaminophen is commonly used to control moderate pain and is metabolized by cytochrome P4502D6 to form the active metabolite, hydromorphone. The purpose of this study was to determine the metabolic relationship and variability between hydrocodone and its conversion to hydromorphone us...

journal_title：Journal of analytical toxicology

authors： Barakat NH,Atayee RS,Best BM,Pesce AJ

更新日期：2012-05-01 00:00:00

abstract：:Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen ...

journal_title：Journal of analytical toxicology

authors： Moore C,Dempsey D,Deitermann D,Lewis D,Leikin J

更新日期：1996-10-01 00:00:00

abstract：:We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium. The FPIA is sensitiv...

journal_title：Journal of analytical toxicology

authors： Clark GD,Rosenzweig IB,Raisys V,Callahan CM,Grant TM,Streissguth AP

更新日期：1992-07-01 00:00:00

abstract：:Ethanol is the most frequently identified compound in forensic toxicology. Although confirmation involving mass spectrometry is desirable, relatively few methods have been published to date. A novel technique utilizing a Dean's Switch to simultaneously quantitate and confirm ethyl alcohol by flame-ionization (FID) and...

journal_title：Journal of analytical toxicology

authors： Tiscione NB,Alford I,Yeatman DT,Shan X

更新日期：2011-09-01 00:00:00

abstract：:Hop-derived iso-α-acid (IAA) ingredient congeners are specific to beer. Concentrations of IAAs were determined in blood of five volunteers over 6 h following the consumption of small volumes of beer containing relatively high (Pale Ale beer) or low (wheat beer) concentrations of IAAs. IAAs were quickly absorbed with p...

journal_title：Journal of analytical toxicology

authors： Rodda LN,Gerostamoulos D,Drummer OH

更新日期：2014-07-01 00:00:00

abstract：:A preliminary investigation was undertaken to determine the feasibility of monitoring saliva levels of drugs for forensic purposes. Single oral doses of the title compounds were administered to healthy volunteers. Plasma and saliva levels were measured and ratios calculated for all drugs except diazepam. Saliva/plasma...

journal_title：Journal of analytical toxicology

authors： Sharp ME,Wallace SM,Hindmarsh KW,Peel HW

更新日期：1983-01-01 00:00:00

abstract：:A high-performance liquid chromatographic method has been developed for the simultaneous analysis of eight frequently used benzodiazepines and some of their metabolites in postmortem samples. The method includes a liquid-liquid extraction with n-hexane-ethyl acetate (70:30, v/v), gradient elution of a C8 reversed-phas...

journal_title：Journal of analytical toxicology

authors： Lambert WE,Meyer E,Xue-Ping Y,De Leenheer AP

更新日期：1995-01-01 00:00:00

abstract：:The maximum stability conditions for cocaine and its metabolite benzoylecgonine (BE) in urine were analyzed. Suggestions were presented after careful review of many studies and personal communications concerning cocaine and BE stability in urine. The optimal storage conditions for urine specimens with cocaine and BE w...

journal_title：Journal of analytical toxicology

authors： Hippenstiel MJ,Gerson B

更新日期：1994-03-01 00:00:00

abstract：:A sensitive method for identifying and quantifying brucine by means of liquid chromatography-tandem mass spectrometry is presented in this article. Based on a solid-phase extraction for human serum, the validation indicated limits of detection and quantification of 0.12 and 0.23 ng/mL, respectively. In one case of let...

journal_title：Journal of analytical toxicology

authors： Teske J,Weller JP,Albrecht UV,Fieguth A

更新日期：2011-05-01 00:00:00