Abstract:
:A preliminary investigation was undertaken to determine the feasibility of monitoring saliva levels of drugs for forensic purposes. Single oral doses of the title compounds were administered to healthy volunteers. Plasma and saliva levels were measured and ratios calculated for all drugs except diazepam. Saliva/plasma ratios for methaqualone, diphenhydramine and secobarbital were all less than one and reasonably consistent between collection times and subjects. The saliva/plasma ratios for codeine were more variable, but always greater than one. Although more detailed investigation is necessary, saliva may be a useful medium for forensic monitoring of drug ingestion.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Sharp ME,Wallace SM,Hindmarsh KW,Peel HWdoi
10.1093/jat/7.1.11subject
Has Abstractpub_date
1983-01-01 00:00:00pages
11-4issue
1eissn
0146-4760issn
1945-2403journal_volume
7pub_type
杂志文章abstract::1-(4-Methylphenyl)-2-pyrrolidin-1-ylhexan-1-one (4'-methyl-alpha-pyrrolidinohexanophenone, MPHP) is a new designer drug that appeared on the illicit drug market. It is mainly metabolized to 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone (HO-MPHP) followed by oxidation to the respective carboxylic acid. For studies on...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/33.4.190
更新日期:2009-05-01 00:00:00
abstract::Gas chromatographic-mass spectrometric (GC-MS) quantitation of 25 cannabis sed oils determined delta 9-tetrahydrocannabinol (THC) concentrations from 3 to 1500 micrograms/g oil. In a pilot study, the morning urine of six volunteers who had ingested 11 or 22 g of the oil, which contained the highest THC content (1500 m...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/21.5.373
更新日期:1997-09-01 00:00:00
abstract::The identification of benzodiazepines (BZD) in biological fluids can be a challenging process. The large number of various BZD in pharmaceutical distribution, with similar core structures, and individual metabolic profiles all contribute to a complicated and time-consuming analysis. The purpose of the current study wa...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.6.433
更新日期:2008-07-01 00:00:00
abstract::Postmortem redistribution (PMR) constitutes a multifaceted process, which complicates the interpretation of drug concentrations by forensic toxicologists. The present study aimed to apply quantitative structure-activity relationship (QSAR) analysis for modeling PMR data of structurally related drugs, 10 benzodiazepine...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku025
更新日期:2014-06-01 00:00:00
abstract::Fentanyl and its analogs, such as acetylfentanyl, have become a concern for potential abuse. Fentanyl compliance monitoring and urine drug testing are becoming increasingly necessary; however, a limited number of fentanyl immunoassays have been validated for clinical use. The purpose of this study was to validate the ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku103
更新日期:2014-11-01 00:00:00
abstract::The Connecticut Department of Public Safety laboratory recently addressed a legal challenge to a hospital alcohol dehydrogenase (ADH)-based serum ethanol determination based on the suggestion of interference by lactate dehydrogenase (LDH)-catalyzed oxidation of lactate. Both ADH- and LDH-oxidations require NAD(+) (pre...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/33.8.561
更新日期:2009-10-01 00:00:00
abstract::A 5-mg dose of cocaine free base applied to the volar forearm skin surface of a volunteer resulted in a maximal urinary benzoylecgonine concentration of 55 ng/mL at 48 h, using discrete urine specimens. A total of 58 micrograms of benzoylecgonine, representing 1.2% of the dose, was excreted in the 96-h urine. An ident...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/14.6.383
更新日期:1990-11-01 00:00:00
abstract::The popularity of designer drugs has increased over the past few years as users seek new, cheap and sometimes "legal" ways to get high. This case report focuses on a case that happened in the City of Henderson, Nevada, which involved the designer drug methoxetamine. Methoxetamine is a psychoactive compound that is str...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkw054
更新日期:2016-10-01 00:00:00
abstract::Estimating the equivalent whole blood ethanol level from a serum or plasma determination has been addressed by numerous articles in both the clinical and forensic literature. All previous studies have either involved sample sizes insufficient for adequate statistical evaluation or have utilized gas chromatography for ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/31.1.23
更新日期:2007-01-01 00:00:00
abstract::A simple, rapid ethanol screen based on a microdiffusion technique (Analytical Systems, Marion Laboratories) has been evaluated and compared to an established enzymatic procedure (Abbott TDx). They showed agreement in 484 of 488 biological specimens and all control specimens. They disagreed on 4 specimens--3 positive ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/12.6.348
更新日期:1988-11-01 00:00:00
abstract::A rapid and simple method is described for the separation of quinidine (Q), its metabolites 3-hydroxyquinidine (30HQ) and 2'oxoquinidinone (QD) as well as the quinidine salt contaminant, dihydroquinidine (DHQ) in plasma by high pressure liquid chromatography (HPLC). A silica column was used with methanol: 1 N ammonium...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.3.153
更新日期:1982-05-01 00:00:00
abstract::A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in o...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.5.401
更新日期:2005-07-01 00:00:00
abstract::Previous measurements of elemental concentrations in liver mitochondria have generally required homogenization and fractionation of liver tissue, a procedure in which it is difficult to rule out ion movement between subcellular units. New techniques involving cryoultramicrotomy of rapidly frozen tissue, high resolutio...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.4.145
更新日期:1985-07-01 00:00:00
abstract::Results of urine drug analyses for three racing greyhounds that tested positive for caffeine in this laboratory were contested by the animal trainer, who asserted that positives were achieved from deliberate chocolate feeding by a rival kennel. The metabolism and excretion of methylxanthines was examined by high-perfo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/12.1.30
更新日期:1988-01-01 00:00:00
abstract::A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During samplin...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.2.160
更新日期:2008-03-01 00:00:00
abstract::Sixteen apparently intact procainamide tablets, in varied stages of drug depletion, were found distributed throughout the gastrointestinal tract of a man who died of arteriosclerotic heart disease with pulmonary complications. The tablets were found to contain procainamide by a thin layer chromatography system with ca...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/8.5.244
更新日期:1984-09-01 00:00:00
abstract::Fentanyl is a potent, short-acting narcotic analgesic widely used as a surgical anesthetic and for the control of pain when administered in the form of a transdermal patch. The success of the patch can be attributed to fentanyl's low molecular weight and its highly lipophilic nature, which enables it to be readily abs...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/24.7.627
更新日期:2000-10-01 00:00:00
abstract::A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.1.28
更新日期:2005-01-01 00:00:00
abstract::Analytical chemical procedures are described to determine residues of the drugs clofibrate and tibric acid in animal feed, wastewater, and human urine. Clofibrate was extracted from animal feed and human urine with hexane, whereas residues from wastewater were collected on a Sep-PakTM then eluted with methanol for ana...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.4.175
更新日期:1982-07-01 00:00:00
abstract::An arsenic death was investigated six and one half years after the demise. Analysis of tissue embedded in paraffin blocks demonstrated toxic concentrations. Spectrophotometry was employed with the use of a hydride generator to provide specificity and sensitivity to less than 0.05 microgram. ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/6.5.260
更新日期:1982-09-01 00:00:00
abstract::A method that measures 12 analytes in urine and reflects possible exposure to pesticides was developed. The sample preparation involves enzyme hydrolysis and solvent extraction through the use of laboratory robotics, followed by phase-transfer catalysis derivatization and silica cleanup. Samples are analyzed by capill...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.5.323
更新日期:1995-09-01 00:00:00
abstract::This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.2.138
更新日期:2004-03-01 00:00:00
abstract::A method is presented for the analysis of trace amounts of dinitroaniline herbicides in tissue and excreta. The method employs extraction of the tissue or excreta with organic solvent, clean up by liquid/liquid partitioning or silica gel chromatography, and ultimate analysis by gas chromatography using electron captur...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/9.1.15
更新日期:1985-01-01 00:00:00
abstract::An analytical procedure for the determination of the new pain medication tapentadol and its main metabolite N-desmethyltapentadol (DMT), in urine and oral fluid has been developed and validated using liquid chromatography with tandem mass spectral detection (LC-MS-MS). Oral fluid was collected using Quantisal™ devices...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/34.8.458
更新日期:2010-10-01 00:00:00
abstract::Synthetic cannabinoids emerged on the designer drug market in recent years due to their ability to produce cannabis-like effects without the risk of detection by traditional drug testing techniques such as immunoassay and gas chromatography-mass spectrometry. As government agencies work to schedule existing synthetic ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv137
更新日期:2016-04-01 00:00:00
abstract::Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/23.1.54
更新日期:1999-01-01 00:00:00
abstract::Oral fluid (OF) is increasingly used for clinical, forensic and workplace drug testing as an alternative to urine. Uncertainties surrounding OF collection device performance, drug stability and testing reproducibility may be partially responsible for delays in the implementation of OF testing in regulated drug testing...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkv093
更新日期:2015-10-01 00:00:00
abstract::This article reports the investigation by 1H nuclear magnetic resonance (1H NMR) spectroscopy of biological fluids in a case of intentional poisoning with tetrahydrofuran (THF). Occupational exposures to this solvent are well documented, but acute poisoning cases are extremely rare, and the one presented here is the s...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.4.270
更新日期:2001-05-01 00:00:00
abstract::Despite the efforts to prevent the spread of new psychoactive substances (NPS) such as synthetic amphetamine derivatives, it is apparent that newer types of NPS are still emerging on the market in recent years. Due to high potential for their abuse, reliable analytical methods are required to determine these substance...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bky037
更新日期:2018-11-01 00:00:00
abstract::Bone was analyzed for ketamine and norketamine to examine whether different patterns of drug exposure could be discriminated. Rats received (intraperitoneally) one 75 mg/kg dose (Acute-1 and Acute-2 groups), three 25-mg/kg doses 1 hour apart (Repeated group), or nine single daily ketamine doses of 75 mg/kg followed by...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bks045
更新日期:2012-07-01 00:00:00