Abstract:
:A 5-mg dose of cocaine free base applied to the volar forearm skin surface of a volunteer resulted in a maximal urinary benzoylecgonine concentration of 55 ng/mL at 48 h, using discrete urine specimens. A total of 58 micrograms of benzoylecgonine, representing 1.2% of the dose, was excreted in the 96-h urine. An identical trial using 5 mg of cocaine hydrochloride resulted in a maximal urinary benzoylecgonine concentration of 15 ng/mL at 24 h. We conclude that dermal absorption of cocaine represents a minor, but significant route of exposure to this drug that needs to be considered when interpreting low-level urine drug testing results.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Baselt RC,Chang JY,Yoshikawa DMdoi
10.1093/jat/14.6.383subject
Has Abstractpub_date
1990-11-01 00:00:00pages
383-4issue
6eissn
0146-4760issn
1945-2403journal_volume
14pub_type
杂志文章abstract::The objective was to develop a simple routine method for quantitative measurement of endogenous formic acid in plasma and whole blood using headspace gas chromatography-flame ionization detection. (GC-FID). Two-hundred microliters of sample was placed in a 1-mL glass vial. Fifty microliters of aqueous ethanol (10%) wa...
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journal_title:Journal of analytical toxicology
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