Abstract:
:High levels of verapamil (1) were found in the blood, stomach contents, and liver and kidney specimens in a fatal overdose case. The drug was extracted from both acid and enzyme digested tissue with ether, chloroform, and 1-chlorobutane and the digests analysed by both high-performance liquid chromatography and gas chromatography. Verapamil was extracted directly from the blood and stomach contents. The extraction efficiencies of each method are discussed. The metabolite, norverapamil (II), was observed in liver and kidney extractions and identified by gas chromatography/mass spectrometry.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Thomson BM,Pannell LKdoi
10.1093/jat/5.3.105subject
Has Abstractpub_date
1981-05-01 00:00:00pages
105-9issue
3eissn
0146-4760issn
1945-2403journal_volume
5pub_type
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