Abstract:
:A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monkeys singly and repeatedly treated with methamphetamine. We have shown that the repeated administration of methamphetamine causes the reduction of urinary excretion of aromatic hydroxylated metabolites. We propose that the method described here can be used for biological monitoring.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Yamamoto T,Takano R,Egashira T,Yamanaka Y,Terada Mdoi
10.1093/jat/13.2.117subject
Has Abstractpub_date
1989-03-01 00:00:00pages
117-9issue
2eissn
0146-4760issn
1945-2403journal_volume
13pub_type
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