Screening of stimulants including designer drugs in urine using a liquid chromatography tandem mass spectrometry system.

abstract：:Estimating the equivalent whole blood ethanol level from a serum or plasma determination has been addressed by numerous articles in both the clinical and forensic literature. All previous studies have either involved sample sizes insufficient for adequate statistical evaluation or have utilized gas chromatography for ...

journal_title：Journal of analytical toxicology

authors： Barnhill MT Jr,Herbert D,Wells DJ Jr

更新日期：2007-01-01 00:00:00

abstract：:The National Institute of Standards and Technology (formerly the National Bureau of Standards), in cooperation with the College of American Pathologists (CAP), has certified the concentrations of phencyclidine (PCP) in two new reference materials (RMs). One of these materials is Standard Reference Material (SRM) 1511,...

journal_title：Journal of analytical toxicology

authors： Tai SS,Christensen RG,Coakley K,Ellerbe P,Long T,Welch MJ

更新日期：1996-01-01 00:00:00

abstract：:Phenazepam and etizolam were the first uncontrolled benzodiazepines available for sale in the UK. Pyrazolam, flubromazepam and diclazepam are not used medicinally anywhere in the world; they are produced exclusively for the uncontrolled, recreational market. It is important to know whether potentially abused drugs lik...

journal_title：Journal of analytical toxicology

authors： O'Connor LC,Torrance HJ,McKeown DA

更新日期：2016-03-01 00:00:00

abstract：:A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C18 columns is described. Samples are analyzed by gas chromatography with nitrogen-selective detection usin...

journal_title：Journal of analytical toxicology

authors： Rifai N,Levtzow CB,Howlett CM,Phillips JC,Parker NC,Cross RE

更新日期：1988-05-01 00:00:00

abstract：:Ethiofencarb is one of the carbamate compounds, which are, in general, less toxic than organophosphorus insecticides. This is due to their reversible acetylcholinesterase inhibition and relative inability to cross the blood-brain barrier. Generally, ethiofencarb is regarded to be of low toxicity (LD(50) > 200 mg/kg); ...

journal_title：Journal of analytical toxicology

authors： Al-Samarraie MS,Karinen R,Rognum T,Hasvold I,Opdal Stokke M,Christophersen AS

更新日期：2009-09-01 00:00:00

abstract：:Screening for emerging drugs of abuse, specifically synthetic cathinones and synthetic cannabinoids, is difficult for high-throughput laboratories as immunoassay kits are often unavailable. Consequently, most laboratories employ liquid chromatography-tandem mass spectrometry (LC-MS-MS) screening, which can be complex ...

journal_title：Journal of analytical toxicology

authors： Neifeld JR,Regester LE,Holler JM,Vorce SP,Magluilo J Jr,Ramos G,Bosy TZ

更新日期：2016-06-01 00:00:00

abstract：:As part of a search for phencyclidine (PCP) antagonists, a series of eleven aryl-substituted PCP analogs were prepared and characterized. TLC and GC elution profiles of these derivatives are described in a number of systems allowing for the tentative identification of the PCP analogs. Further, MS, NMR, UV/vis and IR s...

journal_title：Journal of analytical toxicology

authors： Costa JF,Speaker TJ

更新日期：1983-09-01 00:00:00

abstract：:Previous studies have shown that drug concentrations in blood can change during storage, especially at room temperature, but even labile drugs such as cocaine may be stable in dried blood spots (DBS). A new method has been developed for the analysis of hydrolytically labile drugs in blood spots on filter paper in orde...

journal_title：Journal of analytical toxicology

authors： Alfazil AA,Anderson RA

更新日期：2008-09-01 00:00:00

abstract：:Positive benzoylecgonine (BZE) urinalysis results are sometimes challenged in legal and administrative proceedings on the grounds that the presence of BZE is due to the addition of cocaine to the urine sample with subsequent in vitro hydrolysis to BZE. Consequently, counsel for the respondent or defendant may move tha...

journal_title：Journal of analytical toxicology

authors： Klette KL,Poch GK,Czarny R,Lau CO

更新日期：2000-10-01 00:00:00

abstract：:An ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of 25 common pharmaceuticals in whole blood. The selected pharmaceuticals represent the most frequently detected drugs in our forensic laboratory with basic properties such as analgesics, antid...

journal_title：Journal of analytical toxicology

authors： Nielsen MK,Johansen SS

更新日期：2012-09-01 00:00:00

abstract：:Solid-phase extraction (SPE) and a one-step derivatization are combined with gas chromatography-negative ion chemical ionization-mass spectrometry to simplify a previously reported method for the determination of naltrexone and its metabolite, 6-beta-naltrexol, in human plasma. Deuterated isotopomers of naltrexone and...

journal_title：Journal of analytical toxicology

authors： Huang W,Moody DE,Foltz RL,Walsh SL

更新日期：1997-07-01 00:00:00

abstract：:A case of lethal overdose by heroin ingestion is presented. The concentrations of drugs were measured several hours after death. Heroin, 06-monoacetylmorphine, and morphine were identified and quantitated in blood, urine, and gastrointestinal contents by gas chromatography-mass spectrometry and high-performance liquid...

journal_title：Journal of analytical toxicology

authors： Rop PP,Fornaris M,Salmon T,Burle J,Bresson M

更新日期：1997-05-01 00:00:00

abstract：:Preliminary data regarding the use of vernix caseosa (VC) as an alternative to other biological specimens for the determination of fetal cocaine exposure are presented. Advantages of VC analysis include its presence on all newborn babies, historical record of drug exposure, and ease of collection and storage. Fifteen ...

journal_title：Journal of analytical toxicology

authors： Moore C,Dempsey D,Deitermann D,Lewis D,Leikin J

更新日期：1996-10-01 00:00:00

abstract：:A selective, sensitive, and reliable method was devised to determine concentrations of amitriptyline and its major metabolite, nortriptyline, in human plasma using high-performance liquid chromatography (HPLC) combined with UV and particle beam mass spectrometry (PBMS). Amitriptyline and nortriptyline were effectively...

journal_title：Journal of analytical toxicology

authors： Kudo K,Jitsufuchi N,Imamura T

更新日期：1997-05-01 00:00:00

abstract：:A liquid chromatographic-mass spectrometric assay with atmospheric pressure chemical ionization is presented for quantification (selected-ion mode) of tramadol (T) and O-desmethyltramadol (ODT) in blood plasma after liquid-liquid extraction. The enantiomeric separation was achieved on a Chiralpak AD column containing ...

journal_title：Journal of analytical toxicology

authors： Musshoff F,Madea B,Stuber F,Stamer UM

更新日期：2006-09-01 00:00:00

abstract：:A simple, rapid method for the gas-liquid chromatographic (GLC) determination of valproic acid in serum without prior derivatization on a Nukol wide-bore capillary column is presented. The method was determined to have a lower limit of detection (LOD) of 5 mg/L and a lower limit of quantitation (LOQ) of 10 mg/L; the m...

journal_title：Journal of analytical toxicology

authors： Wohler AS,Poklis A

更新日期：1997-07-01 00:00:00

abstract：:This report describes a possible suicide by overdosage with diltiazem. The decreased, a 39-year-old male who had been under treatment for an unidentified heart condition, was discovered on the bathroom floor in his residence. Comprehensive drug screens performed on available postmortem specimens revealed the presence ...

journal_title：Journal of analytical toxicology

authors： Kalin JR,Wood KM,Lee AJ

更新日期：1994-05-01 00:00:00

abstract：:A liquid chromatographic method was developed for the analysis of indandione and 4-hydroxycoumarin anticoagulant rodenticides in blood serum and liver. The method enabled the measurement of serum and liver concentrations of eight anticoagulant rodenticides: brodifacoum, bromadiolone, chlorophacinone, coumafuryl, couma...

journal_title：Journal of analytical toxicology

authors： Chalermchaikit T,Felice LJ,Murphy MJ

更新日期：1993-01-01 00:00:00

abstract：:The analysis of biological specimens collected at autopsy for the presence of exogenous insulin(s) is of special interest in select death investigations as they may be suspected in the cause of a death. Technical challenges include the limited stability of insulin, and the forensic requirement of differentiating endog...

journal_title：Journal of analytical toxicology

authors： Legg KM,Labay LM,Aiken SS,Logan BK

更新日期：2019-08-23 00:00:00

abstract：:Drug-facilitated sexual assault (DFSA) cases are pretty common in forensic toxicology. In this case report, a 56-year-old female tourist claimed to have been sexually assaulted by five men after having had a drug-spiked alcoholic drink. Urine samples were collected at 38, 44, and 45 hours after the alleged rape. After...

journal_title：Journal of analytical toxicology

authors： Carfora A,Campobasso CP,Cassandro P,Petrella R,Borriello R

更新日期：2020-11-12 00:00:00

abstract：:A fatal case attributed to flecainide intoxication is presented. Quantitation was by capillary gas chromatography with nitrogen-phosphorus detection. The flecainide concentration in the blood was 13 mg/L as compared to a therapeutic range in serum of 0.2-1.0 mg/L. Flecainide concentrations in other specimens were as f...

journal_title：Journal of analytical toxicology

authors： Levine B,Chute D,Caplan YH

更新日期：1990-09-01 00:00:00

abstract：:An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...

journal_title：Journal of analytical toxicology

authors： Miki A,Tatsuno M,Katagi M,Nishikawa M,Tsuchihashi H

更新日期：2002-03-01 00:00:00

abstract：:We describe an assay for measuring cocaine and benzoylecgonine in meconium of infants born to mothers suspected of using cocaine during their pregnancy. The assay involves the use of fluorescence polarization immunoassay (FPIA) to screen for benzoylecgonine in a methanolic extract of the meconium. The FPIA is sensitiv...

journal_title：Journal of analytical toxicology

authors： Clark GD,Rosenzweig IB,Raisys V,Callahan CM,Grant TM,Streissguth AP

更新日期：1992-07-01 00:00:00

abstract：:Two cases of death following the ingestion of tranylcypromine are presented. High concentrations of tranylcypromine were determined in blood, urine, and liver by gas-liquid chromatography. Tranylcypromine was extracted from buffered blood with n-butyl chloride. The evaporated extract was derivatized with trifluoroacet...

journal_title：Journal of analytical toxicology

authors： Boniface PJ

更新日期：1991-01-01 00:00:00

abstract：:While earlier studies have attempted to resolve the challenges encountered when interpreting gamma-hydroxybutyric acid (GHB) concentrations in hair (primarily due to its endogenous presence), few have had large sample sizes. The first objective of this study was to evaluate the inter-individual variation of endogenous...

journal_title：Journal of analytical toxicology

authors： Thomas JL,Strickland EC,Lloyd EW,Donnelly CC,Rankoth A,Pieczonka SM,Colpoys C,Smith MA,LeBeau MA,Montgomery MA,Karas RP,Peters EM,Miller ML

更新日期：2020-10-12 00:00:00

abstract：:The Abbott TDx Urine Amphetamine/Methamphetamine II fluorescence polarization immunoassay technique was applied to the determination of D-methamphetamine in hemolyzed whole blood. The assay was found to have 100% cross-reactivity with D-methamphetamine and only an 8% cross-reactivity with L-methamphetamine. Whole bloo...

journal_title：Journal of analytical toxicology

authors： Simonick TF,Watts VW

更新日期：1992-03-01 00:00:00

abstract：:Part I. Expert 4: The object of this study was to investigate the applicability of commercially available expert system shells to interpretation in forensic toxicology. Amitriptyline toxicology was selected as a pilot trial. Blood and tissue concentrations of amitriptyline and nortriptyline in fatal and nonfatal amitr...

journal_title：Journal of analytical toxicology

authors： Spiehler V,Spiehler E,Osselton MD

更新日期：1988-07-01 00:00:00

abstract：:This report describes a gas chromatographic procedure using a packed column and a flame ionization detector, which is suitable for the therapeutic monitoring of N-methylformamide (N-MF). N-MF is a polar compound that induces cancer cell maturation in vitro and exhibits antitumor activity with human tumors xenografted ...

journal_title：Journal of analytical toxicology

authors： Griffiths WC,Matook GM,Dexter DL,Crabtree GW,Spremulli EN,Calabresi P,Diamond I

更新日期：1983-03-01 00:00:00

abstract：:Benzoylecgonine (BZE) extraction from urine was explored using Cerex Polycrom Clin II solid-phase extraction (SPE) columns and the Speedisk 48 Pressure Processor as an alternative to the Prep1 automated sample processor and XTRX Type RP/W columns. Linearity for urine standards extracted using the Cerex-Speedisk method...

journal_title：Journal of analytical toxicology

authors： Kuhnle JA,Churley M,Kawasaki SY,Lyons TP,Bruins MR

更新日期：2001-10-01 00:00:00

abstract：:A simple, rapid, and reliable gas-liquid chromatographic (GLC) confirmation procedure was developed for urine samples found positive by the EMIT-dau benzodiazepine metabolite assay. The procedure involves acid hydrolysis, organic extraction, and identification using GLC-nitrogen-phosphorus detection (NPD). The method ...

journal_title：Journal of analytical toxicology

authors： Verebey K,Jukofsky D,Mulé SJ

更新日期：1982-11-01 00:00:00