Abstract:
:The misuse of the commonly used chemical diethylene glycol (DEG) has lead to many poisonings worldwide. Methods were developed for analysis of DEG and its potential metabolites; ethylene glycol, glycolic acid, oxalic acid, diglycolic acid and hydroxyethoxy acetic acid in human urine, serum and cerebrospinal fluid samples, collected following a DEG-associated poisoning in the Republic of Panama during 2006. In addition, methods were developed for rat blood, urine, kidney and liver tissue to support toxicokinetic analysis during the conduct of DEG acute toxicity studies in the rat. Sample analysis was conducted using two techniques; ion chromatography with suppressed conductivity and negative ion electrospray ionization with MS detection or with gas chromatography using electron impact ionization or methane negative chemical ionization with MS detection. Stable-isotope-labeled analogs of each analyte were employed as quantitative internal standards in the assays.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Perala AW,Filary MJ,Bartels MJ,McMartin KEdoi
10.1093/jat/bku018subject
Has Abstractpub_date
2014-05-01 00:00:00pages
184-93issue
4eissn
0146-4760issn
1945-2403pii
bku018journal_volume
38pub_type
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