Abstract:
:A 25 mg oral dose of cocaine HCl given to a single volunteer resulted in a peak urinary cocaine concentration of 269 ng/mL at 1 h, and a peak benzoylecgonine concentration of 7,940 ng/mL at 12 h. Urine benzoylecgonine concentrations remained in excess of 300 ng/mL for 48 h. We conclude that small, oral doses of cocaine, potentially undetectable to the user, may cause positive urine test results for at least 48 h using routine detection methods.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Baselt RC,Chang Rdoi
10.1093/jat/11.2.81subject
Has Abstractpub_date
1987-03-01 00:00:00pages
81-2issue
2eissn
0146-4760issn
1945-2403journal_volume
11pub_type
杂志文章abstract::A simple isocratic HPLC procedure for the analysis of cocaine in plasma, with or without an internal standard, is described for the first time. Basified plasma was extracted in ether, re-extracted in acetic acid, which was subsequently basified prior to the final extraction in n-hexane. The hexane extract was evaporat...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/4.6.305
更新日期:1980-11-01 00:00:00
abstract::In mothers who had no prenatal care and in their newborns, the presence of cocaine and benzoylecgonine (BE) was determined in urine, hair, and meconium. Samples of urine and hair were obtained from pregnant women who entered the hospital for delivery. Cocaine usage was assessed by a urinary enzyme-multiplied immunoass...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/18.5.247
更新日期:1994-09-01 00:00:00
abstract::The misuse of the commonly used chemical diethylene glycol (DEG) has lead to many poisonings worldwide. Methods were developed for analysis of DEG and its potential metabolites; ethylene glycol, glycolic acid, oxalic acid, diglycolic acid and hydroxyethoxy acetic acid in human urine, serum and cerebrospinal fluid samp...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku018
更新日期:2014-05-01 00:00:00
abstract::Urinary metabolites of famprofazone following oral administration in humans were identified by gas chromatography-mass spectrometry with electron impact-ionization and comparison with the spectra and retention times of authentic standards. The metabolites were determined following selective derivatization with N-methy...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章
doi:10.1093/jat/22.1.55
更新日期:1998-01-01 00:00:00
abstract::Different analytical procedures for quantitation of total morphine and codeine in urine were evaluated. Hydrolysis of urine with hydrochloric acid and four different enzymes was compared. In order to effect complete hydrolysis of glucuronide conjugates, hydrolysis with 6.5M HCl containing bisulphite and heating at 100...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/18.3.129
更新日期:1994-05-01 00:00:00
abstract::Because mycotoxins occur worldwide in grain and grain products, evaluating their effects on the health of the population has become important. The development of a high performance liquid chromatographic (HPLC) procedure was investigated for the analysis of aflatoxin B1, citrinin, and ochratoxin A, from hydrolyzed hum...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/10.2.41
更新日期:1986-03-01 00:00:00
abstract::The aim of this study is to investigate the concentrations of ethyl glucuronide (EtG) in oral fluid and both EtG and ethyl sulfate (EtS) in blood and urine following intense use of mouthwash and ingestion of nonalcoholic wine, which are proven to contain 3 mg/L EtG, 1.5 mg/L EtS, and 0.2 g/L ethanol. Twelve subjects p...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/34.2.84
更新日期:2010-03-01 00:00:00
abstract::A liquid chromatography-tandem mass spectrometry method was developed for the simultaneous quantification of 26 benzodiazepines and metabolites, zolpidem and zopiclone, in blood, urine, and hair. Drugs were extracted from all matrices by liquid-liquid extraction with 1-chlorobutane. Chromatography was achieved using a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.616
更新日期:2005-10-01 00:00:00
abstract::A group of 16 volatile substances (ethyl acetate, 2-propanol, 1-propanol, methanol, acetone, ethanol, acetaldehyde, diethyl ether, methyl ethyl ketone, 1-butanol, 2-butanol, t-butanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, 1-pentanol) were qualitatively and quantitatively analyzed through a method develo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkaa154
更新日期:2020-10-08 00:00:00
abstract::N,N-Diethyl-m-toluamide (DEET) is an effective component of several insect repellent products. A 19-year-old woman was admitted to the emergency department following ingestion of 15-25 mL 95% diethyltoluamide (Muscol). Serum and urine toxicology screening tests were negative except for detection of DEET. DEET was qual...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/19.3.197
更新日期:1995-05-01 00:00:00
abstract::The concentrations of amphetamine and methamphetamine in a new lyophilized human urine reference material (RM) were determined at the National Institute of Standards and Technology, in cooperation with the College of American Pathologists. In order to minimize the possibility of undetected bias, two different methods ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.3.165
更新日期:1993-05-01 00:00:00
abstract::Endogenous γ-hydroxybutyric acid (GHB) concentrations in blood and urine are well documented, but there are very little data on natural levels in saliva, a biological matrix increasingly used for drug testing. We measured endogenous GHB concentrations in 120 unpaid volunteers who also provided anonymous epidemiologica...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/anatox/35.3.148
更新日期:2011-04-01 00:00:00
abstract::Bupropion is a "second generation" antidepressant agent structurally related to the phenethylamines. Postmortem toxicology data are presented from three suicidal drug overdoses in which bupropion was detected. In two cases in which bupropion was the major toxicology finding, peripheral blood levels of the parent drug ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/17.7.436
更新日期:1993-11-01 00:00:00
abstract::This report describes a possible suicide by overdosage with diltiazem. The decreased, a 39-year-old male who had been under treatment for an unidentified heart condition, was discovered on the bathroom floor in his residence. Comprehensive drug screens performed on available postmortem specimens revealed the presence ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/18.3.180
更新日期:1994-05-01 00:00:00
abstract::The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.678
更新日期:2005-10-01 00:00:00
abstract::A rapid and efficient high-performance liquid chromatographic method using a reversed-phase eluent of methanol-water with butylamine on a silica column was developed for the separation and quantitation of clomipramine (CMI), its demethylated metabolites (desmethyl-clomipramine and didesmethyl-clomipramine [DDCMI]), an...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/20.2.101
更新日期:1996-03-01 00:00:00
abstract::About 22,000 samples of oral fluid have been collected in five population studies in Norway using either the Intercept or Statsure oral fluid sampling devices. The prevalence of alcohol and drugs was found to be higher in oral fluid samples with small volumes than in those with large volumes for both sampling devices;...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/34.7.416
更新日期:2010-09-01 00:00:00
abstract::A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exch...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bku141
更新日期:2015-03-01 00:00:00
abstract::Benzodiazepines are common drugs that cause intoxication. Benzodiazepines and their metabolites can be converted by hydrolysis in acid to the corresponding benzophenones, which are easier to be separated from matrices because of their hydrophobic properties. In this study, a new separation technique called solid-phase...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/23.1.54
更新日期:1999-01-01 00:00:00
abstract::Doxepin is a tricyclic antidepressant that is widely prescribed for the treatment of mild depression. In this study, hair samples collected from a patient receiving 25 mg of doxepin daily were analyzed. Doxepin was administered to the patient for 4 months (June 15 to October 15, 1996). Five hair samples were collected...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/22.6.531
更新日期:1998-10-01 00:00:00
abstract::During periodate degradation of interfering ephedrine, pseudoephedrine, and phenylpropanolamine in the extraction of methamphetamine from urine, it was observed that a small amount of methamphetamine was demethylated to amphetamine. although all three interfering phenylpropanolamines could be degraded by periodate at ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/18.6.331
更新日期:1994-10-01 00:00:00
abstract::A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/24.4.305
更新日期:2000-05-01 00:00:00
abstract::A novel mass spectrometry detection technique based on a multi-period and multi- experiment (MRM-EPI-MRM3) with library matching in a single run for fast and rapid screening and identification of amphetamine type stimulants (ATS) related drugs in whole blood, urine and dried blood stain was developed and validated. Th...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/bkz017
更新日期:2019-08-23 00:00:00
abstract::This study identified ethyl sulfate (EtS) in human urine and compared the excretion characteristics of EtS with that of ethanol and ethyl glucuronide (EtG). Urine samples were collected from healthy subjects after a single ethanol dose, and also selected from routine clinical samples. Simultaneous analysis of EtS and ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.5.270
更新日期:2005-07-01 00:00:00
abstract::The gelsemium plants are highly poisonous but toxicological evaluation of suspected poisoning cases has been hampered by the chemical complexity of the gelsemium toxins involved. A novel liquid chromatography-tandem mass spectrometry protocol was optimized for the collective detection of gelsemine and related alkaloid...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/33.1.56
更新日期:2009-01-01 00:00:00
abstract::This study compares fluoride concentrations ([F]) in surface and whole bone for up to 27 days following an acute oral dose of F. Four groups of rats received single oral F dose (50 mg/kg body weight), and the control group received deionized water (n = 10/group). Groups were euthanized at 1, 3, 9, or 27 days after F a...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.8.810
更新日期:2005-11-01 00:00:00
abstract::Acetaminophen (APAP, n-acetyl-p-aminophenol) and salicylate (ASA, acetylsalicylic acid) are two of the most frequently overdosed drugs reported in the emergency room. Most APAP and ASA tests are performed with analytical instruments in laboratories, which are not always ideal for emergency situations. A rapid membrane...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.6.366
更新日期:2003-09-01 00:00:00
abstract::This study shows a simple, rapid, and specific method for the quantitative determination of cyanide ion in body fluids, especially blood, by fluorimetry. It is based upon the transformation of cyanide ion into hydrocyanic acid, which then reacts with 2,3-naphthalenedialdehyde and taurine in a self-contained system. Th...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/22.5.363
更新日期:1998-09-01 00:00:00
abstract::A blood concentration of tetrahydrocannabinol (THC) in the low nanograms-per-milliliter range is often claimed to result from drug use more than 24-48 h previously. The present investigation determined concentrations of cannabinoids in blood collected at least 24 h from smoking in an in-patient setting. During samplin...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/32.2.160
更新日期:2008-03-01 00:00:00
abstract::A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine. The method has been applied to the analysis of urine samples from monk...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/13.2.117
更新日期:1989-03-01 00:00:00