Abstract：
:Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n = 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry. Results (mean +/- SE) for the 40-mg precise delivery doses are as follows: (Table can not be represented) Mean C(max) for all analytes linearly increased with increasing dose. T(max) was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe.
journal_name
J Anal Toxicoljournal_title
Journal of analytical toxicologyauthors
Huestis MA,Darwin WD,Shimomura E,Lalani SA,Trinidad DV,Jenkins AJ,Cone EJ,Jacobs AJ,Smith ML,Paul BDdoi
10.1093/jat/31.8.462subject
Has Abstractpub_date
2007-10-01 00:00:00pages
462-8issue
8eissn
0146-4760issn
1945-2403journal_volume
31pub_type
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