Enhanced delivery of synthetic oligonucleotides to human leukaemic cells by liposomes and immunoliposomes.

abstract：:A role for post-induction chemotherapy for adult patients with acute myeloblastic leukemia in remission has not been established. We have studied 125 patients with acute myeloblastic leukemia in complete remission to determine the effect on survival of remission maintenance therapy and of early reinduction therapy giv...

journal_title：Leukemia research

authors：

更新日期：1988-01-01 00:00:00

abstract：:Adult T-cell leukemia/lymphoma is a distinct clinical entity characterized by a clonal proliferation of malignant T-lymphocytes. The etiologic agent of the disease is a Human T-cell lymphotropic virus type I. It occurs almost exclusively in areas where the virus is endemic; however the disease develops only in the min...

journal_title：Leukemia research

authors： Zámecníkova A,Al Bahar S,Elshinnawy SE

更新日期：2010-12-01 00:00:00

abstract：:It has been suggested that imatinib mesylate (IM) influences osteogenesis and bone turnover in treated patients. Here we show that the inhibitory effect of IM on cell multiplication is associated with an increased proportion of spliced osteocalcin (OCNs) in leukemia (HL-60) and osteosarcoma cells (MG-63, U-2 OS), desp...

journal_title：Leukemia research

authors： Wihlidal P,Karlic H,Pfeilstöcker M,Klaushofer K,Varga F

更新日期：2008-03-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is rare in Asians living in Asia and possibly in US Asians. In contrast, CLL is the most common leukemia in whites. The basis for this ethnic and geographic variation is unknown. We compared average annual age-adjusted incidence rates (AAIR) of CLL diagnosed from 1972 to 1995 among L...

journal_title：Leukemia research

authors： Gale RP,Cozen W,Goodman MT,Wang FF,Bernstein L

更新日期：2000-08-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm of the hematopoietic stem cell characterized by presence of the oncoprotein BCR-ABL1, which have constitutive tyrosine kinase activity. BCR-ABL1 activation induces aurora kinase A (AURKA) and aurora kinase B (AURKB) expression, which are serine-thr...

journal_title：Leukemia research

authors： Rodrigues Alves AP,Machado-Neto JA,Scheucher PS,Paiva HH,Simões BP,Rego EM,Traina F

更新日期：2016-09-01 00:00:00

abstract：:A rare case of a 46-year-old man who underwent myelodysplastic syndrome, acute monocytic leukemia with FLT3-ITD mutation and splenic disruption following orthotopic liver transplantation is reported. The study of this case may be helpful to understand both the pathogenesis of acute leukemia and new complication of liv...

journal_title：Leukemia research

authors： Zhang GS,Dai CW,Peng HL,Xu YX,Pei MF

更新日期：2006-07-01 00:00:00

abstract：:We have previously shown that HL-60 cells exposed to all-trans retinoic acid (ATRA) after treatment with a non-cytotoxic concentration of vincristine (VCR) result in granulocytic maturation and differentiation, suggesting that VCR might exhibit a synergistic action with ATRA in the treatment of acute promyelocytic leu...

journal_title：Leukemia research

authors： Leung M,Wong K

更新日期：1997-01-01 00:00:00

abstract：:3q26.2/EVI1 rearrangements resulting in EVI1 overexpression play an important role in leukemogenesis and are associated with treatment resistance and a poorer prognosis in patients with acute myeloid leukemia, myelodysplastic syndrome, chronic myeloid leukemia and BCR-ABL negative myeloproliferative neoplasms. In this...

journal_title：Leukemia research

authors： Hu Z,Hu S,Ji C,Tang Z,Thakral B,Loghavi S,Medeiros LJ,Wang W

更新日期：2018-02-01 00:00:00

abstract：:We hypothesized that the lipid second messenger, ceramide, and microtubule-directed chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel and ceramide enhanced paclitaxel-induced cell growth inhibition. Cell ...

journal_title：Leukemia research

authors： Myrick D,Blackinton D,Klostergaard J,Kouttab N,Maizel A,Wanebo H,Mehta S

更新日期：1999-06-01 00:00:00

abstract：:The simultaneous occurrence of two specific acquired chromosomal abnormalities in chronic or acute leukaemias is rare. Inherited chromosomal abnormalities are also rare events in the general population. In chronic myeloid leukaemia (CML), characterised by the t(9;22)(q34;q11), the inv(16)(p13q22) has been described as...

journal_title：Leukemia research

authors： Silva PM,Lourenço GJ,Bognone RA,Delamain MT,Pinto-Junior W,Lima CS

更新日期：2006-01-01 00:00:00

abstract：:A variety of genetic and epigenetic abnormalities were characterized over the last years in Hodgkin and Reed-Sternberg (H-RS) cells of classic Hodgkin Lymphoma (cHL). It was speculated that simultaneous inhibition of multiple signalling pathways might be a promising strategy to target this tumor entity. In the present...

journal_title：Leukemia research

authors： Hartlapp I,Pallasch C,Weibert G,Kemkers A,Hummel M,Re D

更新日期：2009-07-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is ...

journal_title：Leukemia research

authors： Fujieda A,Nishii K,Tamaru T,Otsuki S,Kobayashi K,Monma F,Ohishi K,Nakase K,Katayama N,Shiku H

更新日期：2006-08-01 00:00:00

abstract：:Differentiation between reactive bone marrow suppression due to viral infection and early stages of leukemia can be difficult particularly in young infants. We report on a 2-month-old girl presenting with pancytopenia and positive markers for congenital cytomegalovirus (CMV) infection. Definitive diagnosis of coexisti...

journal_title：Leukemia research

authors： Metzler M,Bruch J,Stachel D,Langer T,Borkhardt A,Harbott J,Rascher W,Holter W

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:Fractionation of mononuclear cells from human fetal liver provides a cell population at early stages of myeloid differentiation which, when cultured, generates neutrophils and macrophages for up to a month. These studies describe the further purification of an undifferentiated myeloid blast cell population by rosette ...

journal_title：Leukemia research

authors： Bunce CM,Patton WN,Pound JD,Lord JM,Brown G

更新日期：1990-01-01 00:00:00

abstract：:This report describes a unique case of acute myeloid leukemia with hypergranular cytoplasm and t(X;11)(q24;q23). The breakpoint on 11q23 was identified within the MLL gene. The hypergranular cytoplasm of leukemic cells and the associated coagulopathy resembled a characteristic of acute promyelocytic leukemia, despite ...

journal_title：Leukemia research

authors： Nakata Y,Mori T,Yamazaki T,Suzuki T,Okazaki T,Kurosawa Y,Kinoshita A,Ohyashiki K,Nakazawa S

更新日期：1999-01-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....

journal_title：Leukemia research

authors： Zhang J,Yamada O,Matsushita Y,Chagan-Yasutan H,Hattori T

更新日期：2010-06-01 00:00:00

abstract：:Forty patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) preceded by MDS were treated with intensive induction and consolidation chemotherapy in a prospective multicenter pilot study. They were given two cycles of cytarabine 100 mg/m with 12-h intervals on days 1-7 and idarubicin 12...

journal_title：Leukemia research

authors： Ruutu T,Hänninen A,Järventie G,Koistinen P,Koivunen E,Kätkä K,Nousiainen T,Oksanen K,Pelliniemi TT,Remes K,Timonen T,Volin L,Elonen E

更新日期：1997-02-01 00:00:00

abstract：:Thirty patients with high-risk myelodysplastic syndrome, defined as > 5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months wa...

journal_title：Leukemia research

authors： Letendre L,Noel P,White WL,Tefferi A,Litzow MR,Li CY,Schroeder G

更新日期：1999-09-01 00:00:00

abstract：:Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfu...

journal_title：Leukemia research

authors： Ferrero D,De Fabritiis P,Amadori S,De Felice L,Gallo E,Meloni G,Pregno P,Pulsoni A,Simone F,Tarella C

更新日期：1987-01-01 00:00:00

abstract：:Hyaluronan (HA) modulates multidrug resistance (MDR) as well as cell migration. Tiam1 is involved in cytoskeleton reorganization during tumor invasion. In this report we show the relationship among HA, Tiam1, migration and MDR in murine lymphoma cell lines. We observed that MDR cells presented higher migratory capacit...

journal_title：Leukemia research

authors： Cordo-Russo RI,Alaniz LD,Saccodossi N,Lompardía S,Blanco G,Alvarez E,García MG,Hajos SE

更新日期：2010-11-01 00:00:00

abstract：:The remarkable capacity of the bone marrow to compensate for blood loss and for reduced atmospheric oxygen tension has been found to be mediated by a renal hormone, named erythropoietin. It is produced by peritubular interstitial cells in response to renal hypoxia, but molecular engineering has permitted large scale p...

journal_title：Leukemia research

authors： Erslev AJ

更新日期：1990-01-01 00:00:00

abstract：:We investigated the role of Src family kinases (SFKs) in the regulation of STAT activation in myeloid leukemia cells. Two of 6 AML cell lines displayed constitutive STAT5 activation, whereas four cell lines had constitutive SFK activity. Treatment with the SFK inhibitors suppressed STAT5 activation and decreased viabi...

journal_title：Leukemia research

authors： Ozawa Y,Williams AH,Estes ML,Matsushita N,Boschelli F,Jove R,List AF

更新日期：2008-06-01 00:00:00

abstract：:As a part of our continuing efforts to develop gene therapy for acute myelogenous leukemia (AML), this study was undertaken to evaluate the possibility of using autologous bone marrow stromal fibroblasts (BMSFs) as a target cell population. Autologous BMSFs in AML were isolated from the stromal layers of long-term bon...

journal_title：Leukemia research

authors： Min YH,Li GX,Jang JH,Suh HC,Kim JS,Cheong JW,Lee ST,Hahn JS,Ko YW

更新日期：2002-04-01 00:00:00

abstract：:Although recent advances in chemotherapy have markedly improved outcome of acute lymphoblastic leukemia (ALL), infantile ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy. We have shown that specific cytokines FLT3 ligand and TGFβ1 both of which are produced from bone marrow stromal cells synerg...

journal_title：Leukemia research

authors： Ando N,Furuichi Y,Kasai S,Tamai M,Harama D,Kagami K,Abe M,Goi K,Inukai T,Sugita K

更新日期：2018-12-01 00:00:00

abstract：:The importance of IL-18, although clearly established in solid tumors, has not been fully elucidated in human hematopoietic neoplasms. Here we examined the mRNA and protein for IL-18 in eight human hematopoietic cell lines representing different lineages and neoplasms including leukemia, lymphoma and others. Our resul...

journal_title：Leukemia research

authors： Zhang B,Ma XT,Zheng GG,Li G,Rao Q,Wu KF

更新日期：2003-09-01 00:00:00

abstract：:Gain-of-function mutations in the proto-oncogene c-kit that induce constitutive kinase activity of its product, KIT protein, are characteristic of human mast cell disease and are believed to play a central role in mast cell leukemia oncogenesis, proliferation and survival. Nuclear overexpression of the Wnt effector be...

journal_title：Leukemia research

authors： Kajiguchi T,Lee S,Lee MJ,Trepel JB,Neckers L

更新日期：2008-05-01 00:00:00

abstract：:The results of allogeneic marrow transplantation in 75 patients with acute lymphoblastic leukemia and 63 patients with acute non-lymphoblastic leukemia in relapse are reviewed. The effects of various chemotherapeutic regimens added to the basic regimen of cyclophosphamide (Cy) 60 mg/kg given on each of two successive ...

journal_title：Leukemia research

authors： Badger C,Buckner CD,Thomas ED,Clift RA,Sanders JE,Stewart PS,Storb R,Sullivan KM,Shulman H,Flournoy N

更新日期：1982-01-01 00:00:00

abstract：:Infant leukemia cells with 46XY,t(11; 17)(q23; p13) karyotype and a hybrid pre B myeloid phenotype (HLA-DR, (Ia), B4 and My7-positive and CALLA and T11-negative) and immunoglobulin heavy chain gene rearrangement were maintained in long-term culture for over 10 months. The in-vitro survival and growth of the leukemia c...

journal_title：Leukemia research

authors： Umiel T,Friedman S,Zaizov R,Cohen IJ,Gozes Y,Epstein N,Kobiler D,Zipori D

更新日期：1986-01-01 00:00:00

abstract：:Cell line PER-423 was derived from the cells of a patient with an immature acute T-lymphoblastic leukaemia and the growth of this human cell line is strictly dependent on interleukin-2 (IL-2). PER-423 cells express the p75 (beta) subunit of the IL-2 receptor (IL-2R beta), while the p55 chain (IL-2R alpha) is not detec...

journal_title：Leukemia research

authors： Kees UR,Ford J,Peroni SE,Ranford PR

更新日期：1993-01-01 00:00:00