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Acute myeloid leukemia with hypergranular cytoplasm accompanied by t(X;11)(q24;q23) and rearrangement of the MLL gene.

Abstract：

:This report describes a unique case of acute myeloid leukemia with hypergranular cytoplasm and t(X;11)(q24;q23). The breakpoint on 11q23 was identified within the MLL gene. The hypergranular cytoplasm of leukemic cells and the associated coagulopathy resembled a characteristic of acute promyelocytic leukemia, despite the absence of RARalpha gene rearrangement in this case. The Xq24 site possibly played a role in this atypical blast phenotype.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Nakata Y,Mori T,Yamazaki T,Suzuki T,Okazaki T,Kurosawa Y,Kinoshita A,Ohyashiki K,Nakazawa S

doi

10.1016/s0145-2126(98)00131-3

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

85-8

issue

1

eissn

0145-2126

issn

1873-5835

pii

S0145212698001313

journal_volume

23

pub_type

杂志文章

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