The venom of the spider Macrothele raveni induces apoptosis in the myelogenous leukemia K562 cell line.

abstract：:This paper reports the results of a case control study of non-Hodgkin's lymphoma in the Yorkshire Health Region. In all, 437 cases and 724 controls were interviewed. Risk factors associated with past skin conditions, family history of cancer and infectious mononucleosis, aspects of social life and contact with wood du...

journal_title：Leukemia research

authors： Cartwright RA,McKinney PA,O'Brien C,Richards ID,Roberts B,Lauder I,Darwin CM,Bernard SM,Bird CC

更新日期：1988-01-01 00:00:00

abstract：:Feulgen-DNA cytophotometry and 3H-thymidine autoradiography were used to evaluate therapeutic cytapheresis effects on cell cycle distributions of peripheral blood leukemic cells in 15 acute leukemia, 5 CML and 8 CLL patients and of bone marrow erythroblasts in 18 PV patients. Both individual cytapheresis procedures an...

journal_title：Leukemia research

authors： Kotelnikov VM,Kasatkina VV,Dultsina SM,Sarytcheva TG,Kalinin NN,Kovaleva LG,Poljanskaja AM,Isajev VG,Khoroshko ND,Lishmanova NG

更新日期：1987-01-01 00:00:00

abstract：:An overview is given of the effects of X-irradiation, ovariohysterectomy and estradiol-17 beta administration on mammary tumorigenesis in females of 3 rat strains, viz. the WAG/Rij, BN/BiRij and SD. The 3 rat strains differed significantly in their spontaneous mammary tumor incidence. Female SD rats had the highest in...

journal_title：Leukemia research

authors： Solleveld HA,van Zwieten MJ,Broerse JJ,Hollander CF

更新日期：1986-01-01 00:00:00

abstract：:Human peripheral blood monocytes were found to be capable of phagocytizing human B-non Hodgkin's lymphoma (NHL) cells coated with mouse monoclonal antibodies (MoAbs). The MoAbs used recognized idiotypic determinants on the surface immunoglobulin (Ig) of the tumor cells. MoAbs of IgG1 and IgG2a subclass were equally ef...

journal_title：Leukemia research

authors： Calafat J,Janssen H,Hekman A

更新日期：1986-01-01 00:00:00

abstract：:Acute myeloid leukemia is an aggressive disease that arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. Deletions on the long arm of chromosome 9 (del(9q)) are observed in 2% of acute myeloid leukemia patients. Our deletion analysis in a cohort of 31 del(9q) acute myeloid leuke...

journal_title：Leukemia research

authors： Naarmann-de Vries IS,Sackmann Y,Klein F,Ostareck-Lederer A,Ostareck DH,Jost E,Ehninger G,Brümmendorf TH,Marx G,Röllig C,Thiede C,Crysandt M

更新日期：2019-01-01 00:00:00

abstract：:Philadelphia-positive chronic myeloid leukemia (Ph+ CML) patients who are resistant to imatinib are commonly treated with second-generation tyrosine kinase inhibitors (TKIs). Limited data exist on the possible effects of these drugs on subsequent allogeneic hematopoietic stem cell transplantation (allo-HSCT).The outco...

journal_title：Leukemia research

authors： Breccia M,Palandri F,Iori AP,Colaci E,Latagliata R,Castagnetti F,Torelli GF,Usai S,Valle V,Martinelli G,Rosti G,Foà R,Baccarani M,Alimena G

更新日期：2010-02-01 00:00:00

abstract：:Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has also been performed at single cell level. Clonal evolution was observed ...

journal_title：Leukemia research

authors： Nagy Z,Kajtár B,Jáksó P,Dávid M,Kosztolányi S,Hermesz J,Kereskai L,Pajor L,Alpár D

更新日期：2011-08-01 00:00:00

abstract：:Ml cells were labeled in vitro with [3H]thymidine and injected into the peritoneal cavity of syngeneic mice. After several days the peritoneal cells were harvested and [3H]labeled cells were determined by autoradiography. The inoculated isotope-labeled Ml cells differentiated in the peritoneal cavity and lipopolysacch...

journal_title：Leukemia research

authors： Honma Y,Hayashi M,Kasukabe T,Hozumi M

更新日期：1982-01-01 00:00:00

abstract：:3-Aminobenzamide, a general inhibitor of poly(ADP-ribose)polymerase, potentiated the triamcinolone acetonide-mediated growth inhibition and lysis of the glucocorticoid-sensitive CEM-C7 human leukemic cell line. This potentiation was dose-dependent with maximal response being detected at 3 mM 3-aminobenzamide, and was ...

journal_title：Leukemia research

authors： Meyer AS,Schlechte JA,Schmidt TJ

更新日期：1990-01-01 00:00:00

abstract：:We analyzed the biological activity of HA14-1, a small organic compound inhibitor of Bcl-2, against established leukaemia cell lines and blasts from acute myeloid leukaemia (AML) patients. HA14-1 had a potent killing activity against the leukaemia cell line that expressed endogenous or ectopic Bcl-2. This activity was...

journal_title：Leukemia research

authors： Oliver L,Mahé B,Gréé R,Vallette FM,Juin P

更新日期：2007-06-01 00:00:00

abstract：:Migration of eosinophil (Eo) into tissues is a hallmark of chronic eosinophilic leukaemia (CEL), but the exact mechanism involved in cell migration is unknown. We report on a patient with CEL who presented high expressions of VLA-4, LFA-1 and Mac-1 integrins on the Eo surface, increased chemotaxis of Eo to eotaxin, de...

journal_title：Leukemia research

authors： Lima CS,Franco-Penteado CF,Canalli AA,Conran N,Lorand-Metze I,Costa FF,Ferreira HH

更新日期：2007-05-01 00:00:00

abstract：:We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) recei...

journal_title：Leukemia research

authors： Holtzer-Goor KM,Bouwmans-Frijters CA,Schaafsma MR,de Weerdt O,Joosten P,Posthuma EF,Wittebol S,Huijgens PC,Mattijssen EJ,Vreugdenhil G,Visser H,Peters WG,Erjavec Z,Wijermans PW,Daenen SM,van der Hem KG,van Oers MH,Groot

更新日期：2014-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is associated with overexpression of BCR-ABL1, a nonreceptor tyrosine kinase critical for malignant transformation. We investigated whether non-coding microRNAs (miRNAs) targeting BCR-ABL1 mRNA contribute to the pathogenesis of CML. Indeed, miR-30a targeted BCR-ABL1 and was underexpresse...

journal_title：Leukemia research

authors： Liu Y,Song Y,Ma W,Zheng W,Yin H

更新日期：2013-03-01 00:00:00

abstract：:Cases of leukemia associated with Turner syndrome (TS) are rare. Here we report three TS patients with leukemia including one case of T-large granular lymphocyte leukemia (T-LGL), one rare case of coexistence of chronic lymphocytic leukemia (CLL) and idiopathic myelofibrosis (IMF) and one case of a patient with AML-M2...

journal_title：Leukemia research

authors： Manola KN,Sambani C,Karakasis D,Kalliakosta G,Harhalakis N,Papaioannou M

更新日期：2008-03-01 00:00:00

abstract：:The in-vitro effects of deoxycoformycin (dCF) on dATP, NAD, ATP and DNA strand breaks have been evaluated in the cells from 42 patients with various types of chronic lymphoid leukemia. These included 18 with B-cell chronic lymphoid leukemias of different types (BCL); 10 with hairy cell leukemia (HCL) and 14 with T-cel...

journal_title：Leukemia research

authors： Ganeshaguru K,Ho AD,Piga A,Catovsky D,Hoffbrand AV

更新日期：1987-01-01 00:00:00

abstract：:Immunoglobulin gene rearrangements can be used as genetic markers of clonality in the study of B-cell populations [4]. We have therefore analysed the structure and expression of heavy and light chain immunoglobulin genes in lymphocytes of a patient with chronic lymphocytic leukemia, where we found both k and lambda pr...

journal_title：Leukemia research

authors： del Senno L,Gandini D,Gambari R,Lanza F,Tomasi P,Castoldi G

更新日期：1987-01-01 00:00:00

abstract：:Inosine 5'-monophosphate (IMP) dehydrogenase catalyzes the rate-limiting reaction of guanine nucleotide biosynthesis and has been implicated in the reaction of cell growth and differentiation. We investigated the ability of mycophenolate mofetil, a prodrug of mycophenolic acid, to induce differentiation in HL-60 and U...

journal_title：Leukemia research

authors： Inai K,Tsutani H,Yamauchi T,Fukushima T,Iwasaki H,Imamura S,Wano Y,Nemoto Y,Naiki H,Ueda T

更新日期：2000-09-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is frequently treated with induction and consolidation chemotherapy. Consolidation chemotherapy can be delivered on an ambulatory basis, requiring some patients to travel long distances for treatment at specialized centers. We developed a shared care model where patients receive consolidat...

journal_title：Leukemia research

authors： Hershenfeld SA,Maki K,Rothfels L,Murray CS,Nixon S,Schimmer AD,Doherty MC

更新日期：2017-08-01 00:00:00

abstract：:To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...

journal_title：Leukemia research

authors： Ihara T,Yasuda N,Isaji M,Torigoe S,Ito M,Kamiya H,Sakurai M

更新日期：1994-07-01 00:00:00

abstract：:Cytogenetic analysis provides important diagnostic and prognostic information for patients with myelodysplastic syndromes (MDS). Prior studies, mostly comprised of small sample sizes, have reported conflicting results while evaluating the usefulness of FISH in addition to G-band karyotyping in MDS. In the current stud...

journal_title：Leukemia research

authors： Yang W,Stotler B,Sevilla DW,Emmons FN,Murty VV,Alobeid B,Bhagat G

更新日期：2010-04-01 00:00:00

abstract：:Although clinical experience and in vitro data provide evidence of an anti-leukemic activity of T cells, there are few examples of recognition of leukemic cells by tumor-specific T cells in vitro. Tumor antigens encoded by the MAGE genes are useful tools to study this recognition. We tested the sensitivity to recognit...

journal_title：Leukemia research

authors： Chambost H,Collette Y,Dutartre H,Thuret I,Olive D

更新日期：2000-10-01 00:00:00

abstract：:A permanent lymphoblastoid cell line was established from the peripheral blood of a child with acute lymphoblastic leukemia. The cell line, designated SDK, grows in a stationary suspension culture, forming aggregates, in RPMI medium supplemented with 10% FCS, with a doubling time of 50-60 h. Immunologic markers and cy...

journal_title：Leukemia research

authors： Kottaridis S,Perez S,Kokkinopoulos D,Delinassios JG,Pangalis GA,Cosmidis H,Goula I,Papamichail M

更新日期：1985-01-01 00:00:00

abstract：:There is resurgent interest in glucocorticoids (GCs) in the treatment of poor prognosis chronic lymphocytic leukemia (CLL). Little is known however on how GCs induce apoptosis in CLL. Methylprednisolone (MP) induces apoptosis in ZAP-70 positive CLL more readily than in ZAP-70 negative CLL, which is in contrast to the ...

journal_title：Leukemia research

authors： Boelens J,Lust S,Van Bockstaele F,Van Gele M,Janssens A,Derycke L,Vanhoecke B,Philippé J,Bracke M,Offner F

更新日期：2009-10-01 00:00:00

abstract：:The methylation inhibitor decitabine (DAC) has great therapeutic value for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, DAC monotherapy is associated with relatively low rates of overall response and complete remission. Previous studies have shown promising results for combination treatmen...

journal_title：Leukemia research

authors： Geng S,Yao H,Weng J,Tong J,Huang X,Wu P,Deng C,Li M,Lu Z,Du X

更新日期：2016-05-01 00:00:00

abstract：:We studied differentiation inducing effects of retinoic acid (RA), 1 alpha, 25-dihydroxyvitamin D3 (D3) and interferons (IFNs), alone and in combination, on fresh myeloid leukemic cells from 8 patients. RA not only induced the differentiation of leukemic cells in 5/8 cases, but potentiated differentiation by IFNs eith...

journal_title：Leukemia research

authors： Nakamaki T,Sakashita A,Hino K,Suzuki K,Tomoyasu S,Tsuruoka N,Honma Y,Hozumi M

更新日期：1990-01-01 00:00:00

abstract：:Deletion in chromosome 9p involving the CDKN2A locus (9p21.3) is known in many malignancies. To detect this deletion in adolescent ALL patients we used oligo array CGH and studied 54 patients aged 10-25 years. Deletion rate was 25/54 (46%), of these 19/25 (76%) were homozygous. Small deletions (<200 kb) were found in ...

journal_title：Leukemia research

authors： Usvasalo A,Savola S,Räty R,Vettenranta K,Harila-Saari A,Koistinen P,Savolainen ER,Elonen E,Saarinen-Pihkala UM,Knuutila S

更新日期：2008-08-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is ...

journal_title：Leukemia research

authors： Fujieda A,Nishii K,Tamaru T,Otsuki S,Kobayashi K,Monma F,Ohishi K,Nakase K,Katayama N,Shiku H

更新日期：2006-08-01 00:00:00

abstract：:Based on Bcl-X(L) overexpression studies we identified type I and type II follicular lymphoma cell lines in response to TRAIL. We demonstrate here that either amount of caspase-8 activation or Bid cleavage could not define the dependence on mitochondria. Furthermore, an inhibitor of NF-kappaB, PDTC, enabled TRAIL to a...

journal_title：Leukemia research

authors： Nuutinen U,Simelius N,Ropponen A,Eeva J,Mättö M,Eray M,Pellinen R,Wahlfors J,Pelkonen J

更新日期：2009-06-01 00:00:00

abstract：:Clinicopathological features of 36 patients, male: 58.3%; median: 68 years, with "peripheral T-cell lymphoma, unspecified" diagnosed by the WHO criteria were reviewed. Majority (69.4%) had stage IV disease with frequent involvements into bone marrow, spleen, liver, and skin. According to the IPI, 72.2% were categorize...

journal_title：Leukemia research

authors： Kojima H,Hasegawa Y,Suzukawa K,Mukai HY,Kaneko S,Kobayashi T,Kamoshita M,Shinagawa A,Komeno T,Komatsu T,Mitsuhashi S,Kawachi Y,Yamashita Y,Mori N,Nagasawa T

更新日期：2004-12-01 00:00:00

abstract：:Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxicity in human acute promyelocytic leukemia NB4 cells by early disturbance in mitochondrial function and oxidative stres...

journal_title：Leukemia research

authors： García-Pérez AI,Galeano E,Nieto E,Estañ MC,Sancho P

更新日期：2014-07-01 00:00:00