Abstract：
:The goal of this study was to ascertain the specific effects of 17-N-Allylamino-17-demethoxygeldanamycin (17-AAG) treatment in human acute myelogenous leukemia (AML). Four human leukemia cell lines were treated with varying doses of 17-AAG followed by analysis of toxicity, apoptosis, proliferation, and cell cycle. Cell cycle analysis revealed that the cells accumulate in G2/M phase within 96 h of treatment, although the effect was not equivalent among the cell lines. p21, p53 expression and MDR1 activity were among the possible mechanisms uncovered for the differing responses. Exploiting these differences may allow for more effective combinatory treatments in patients with AML.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Napper JM,Sollars VEdoi
10.1016/j.leukres.2010.05.024subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1493-500issue
11eissn
0145-2126issn
1873-5835pii
S0145-2126(10)00283-3journal_volume
34pub_type
杂志文章abstract：BACKGROUND:Current results regarding treatment outcomes in acute myeloid leukemia (AML) point to significant differences between low- and middle-income countries (LMIC) and high-income countries (HIC). Excluding well-known socioeconomic issues, genetic markers important for prognosis have not been properly incorporated...
journal_title：Leukemia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.leukres.2017.07.005
更新日期：2017-09-01 00:00:00
abstract：:The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cispl...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章
doi：10.1016/0145-2126(94)90064-7
更新日期：1994-09-01 00:00:00
abstract：:The capacity of human thymocytes and of differentiated lymphocytes circulating in peripheral blood to perform unscheduled DNA synthesis (a measure of nucleotide excision repair) after UV irradiation was measured by radioautographic analysis. Only 4% of immature T lymphocytes, but 68% of circulating lymphocytes exhibit...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90006-2
更新日期：1985-01-01 00:00:00
abstract：:Expression of p14(ARF) and p16(INK4a) tumor suppressor genes was investigated in 109 patients with chronic myeloid leukemia (CML). The p14(ARF) and p16(INK4a) mRNA levels were significantly low in patients in chronic phase (CP) at presentation and high in patients treated with interferon-alpha (IFN-alpha), especially ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2006.02.002
更新日期：2006-10-01 00:00:00
abstract：:Chronic B-lymphocytic leukemia (B-CLL) cells may be regulated by immune functions. In an attempt to analyze such functions, helper factors (IL-1 alpha, IL-1 beta and IL-6), T-cell products (sCD4 and sCD8) and sIL-2R and beta 2-microglobulin were measured in serum of patients at different stages of the disease. Patient...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(92)90009-v
更新日期：1992-06-01 00:00:00
abstract：:We investigated the expression of fos oncogene proteins in lymphoproliferative disorders, using a monoclonal antibody (FO-120) that was prepared against a synthetic oligopeptide of fos protein (amino acid sequence from 127 to 152). Although peripheral blood leukocytes were rarely positive for FO-120, they were transie...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(89)90010-6
更新日期：1989-01-01 00:00:00
abstract：:The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(88)90090-2
更新日期：1988-01-01 00:00:00
abstract：:Bone marrow cells from 109 patients (median age 60) with newly diagnosed acute myeloid leukaemia (AML) were prospectively immunophenotyped (IP) and the prognostic value of monoclonal antibody (MAB) reactivities was analysed to detect differences in complete remission rates and survival, not only between groups of MAB ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(91)90071-z
更新日期：1991-01-01 00:00:00
abstract：:Mantle cell lymphoma (MCL) is a distinct type of B cell malignancy and accounts for approximately 5-10% of non-Hodgkin's lymphomas (NHL). The characteristic cytogenetic aberration in MCL is the translocation (11;14)(q13;q32) present in virtually all cases. This rearrangement at the BCL1 locus at 11q13 dysregulates the...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00026-7
更新日期：2002-09-01 00:00:00
abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three distinct lymphoproliferative disorders: primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and germinotropic lymphoproliferative disorder (GLD). KSHV positive lymphocytes in GLD and in most cases of PEL are co-infected by Epst...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2003.08.003
更新日期：2004-04-01 00:00:00
abstract：:Pro-apoptotic signalling upon toll-like receptor (TLR) stimulation in myeloid cells is normally antagonized by the simultaneous activation of anti-apoptotic pathways. We have previously reported that IFN-alpha can sensitize human monocytes to apoptosis induction by lipopolysaccharide (LPS). Based on these results we i...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2007.05.001
更新日期：2007-12-01 00:00:00
abstract：:We performed a systematic review and meta-analysis of all trials comparing MMF and methotrexate as GVHD prophylaxis. Our search yielded 11 studies; 3 were randomized-control trials (RCTs). While the incidence of grades 2-4 acute GVHD was comparable, the incidence of grades 3 and 4 acute GVHD was higher in patients giv...
journal_title：Leukemia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.leukres.2013.12.012
更新日期：2014-03-01 00:00:00
abstract：:Replication of the Friend spleen focus forming virus (SFFV) in C3H/HeJ or C57BL/6J mouse continuous bone marrow cultures is associated with an increased cumulative production of pluripotential/hematopoietic stem cells (CFUs), granulocyte-macrophage progenitor cells (GM-CFUc), and total granulocytes, compared to uninfe...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(83)90133-9
更新日期：1983-01-01 00:00:00
abstract：:Cell line PER-423 was derived from the cells of a patient with an immature acute T-lymphoblastic leukaemia and the growth of this human cell line is strictly dependent on interleukin-2 (IL-2). PER-423 cells express the p75 (beta) subunit of the IL-2 receptor (IL-2R beta), while the p55 chain (IL-2R alpha) is not detec...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(93)90141-7
更新日期：1993-01-01 00:00:00
abstract：:Ten patients with acute nonlymphocytic leukemia (ANLL) received bromodeoxyuridine (BrdU) at 100 mg/M2 intravenously over 1 h. BrdU is incorporated into the DNA by S-phase cells and was detected by using a monoclonal anti-BrdU antibody in the bone marrow aspirate (BM) and biopsy specimens obtained at the end of the inf...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(87)90160-3
更新日期：1987-01-01 00:00:00
abstract：:The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytoche...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.03.017
更新日期：2012-07-01 00:00:00
abstract：:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic meta...
journal_title：Leukemia research
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.leukres.2013.01.020
更新日期：2013-05-01 00:00:00
abstract：:c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be therapeutically useful but might require the identification of critical downstream proteins. Here we show that the serine-threonine kinase PBK/TOPK is frequently overexpresse...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.11.010
更新日期：2013-04-01 00:00:00
abstract：:To improve the recovery rate of high-risk patients with acute promyelocytic leukemia (APL), we used all-trans retinoic acid (ATRA)/arsenic trioxide (ATO)/daunorubicin combination in remission induction, daunorubicin and cytarabine in consolidation, and ATRA/ATO/methotrexate ± 6-mercaptopurine in maintenance treatment ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2012.03.027
更新日期：2012-07-01 00:00:00
abstract：:Microtubular reorganisation contributing to apoptotic morphology occurs in normal and neoplastic cells undergoing apoptosis induced by cytotoxic drugs [1-3]. The aim of this study was to correlate the changes in the microtubules (MTs) with behavior of the centrosome in apoptotic cells, and to see whether post-translat...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(97)00038-6
更新日期：1997-06-01 00:00:00
abstract：:We hypothesized that the lipid second messenger, ceramide, and microtubule-directed chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel and ceramide enhanced paclitaxel-induced cell growth inhibition. Cell ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(99)00048-x
更新日期：1999-06-01 00:00:00
abstract：:Smoking is associated with both acute myeloid leukemia (AML) and lung cancer. We therefore searched our database for concomitant presentation of AML and lung cancer. Among 775 AML cases and 5225 lung cancer cases presenting to Roswell Park Cancer Institute between the years January 1992 and May 2008 we found 12 (1.5% ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2008.12.016
更新日期：2009-09-01 00:00:00
abstract：:Murine erythroleukemia (MEL) cells undergo erythroid differentiation in vitro when treated with hexamethylene bisacetamide (HMBA). To identify genes involved in the commitment of MEL cells to differentiate, we screened a cDNA library constructed from HMBA-induced cells by differential hybridization and isolated GTPase...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/s0145-2126(02)00231-x
更新日期：2003-07-01 00:00:00
abstract：:Thrombohaemorrhagic complications are major clinical problems in the classical chronic Ph-negative myeloproliferative disorders (CMPDs), polycytaemia vera (PV), essential thrombocythaemia (ET) and idiopathic myelofibrosis (IMF), contributing significantly to morbidity and mortality. Pathophysiologically these disorder...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/j.leukres.2005.12.018
更新日期：2006-10-01 00:00:00
abstract：:We described the clinical features and outcomes for 63 adult patients with acute myeloid leukemia (AML) with a translocation involving the 11q23 locus (MLL) who were treated at Memorial Sloan Kettering Cancer Center (MSK). The population included 40 female (63 %) and 23 male (37 %) patients, with a median age of 51 ye...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2020.106453
更新日期：2020-11-01 00:00:00
abstract：:Leukotrienes and lipoxins are bioactive lipoxygenase products formed by leukocytes alone or in collaboration with other cells. While the physiological role of lipoxins remains to be clarified, accumulating evidence shows that leukotrienes are important mediators in asthma and inflammation. Consequently, recent clinica...
journal_title：Leukemia research
pub_type： 杂志文章,评审
doi：10.1016/0145-2126(94)90053-1
更新日期：1994-10-01 00:00:00
abstract：:An insertion (10;11)(p11;q23q24) was found in bone marrow metaphase cells from two children with acute monocytic leukemia (AMoL-M5b). This rearrangement involves a small chromosomal segment of 11q and may be misinterpreted as a deletion of 11q. Insertion (10;11) may represent a new recurring abnormality involving 11q ...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/0145-2126(85)90140-7
更新日期：1985-01-01 00:00:00
abstract：:We examined the antineoplastic effects of the iron chelators, deferasirox and deferoxamine in multiple myeloma cell lines as well as primary myeloma cells. These iron chelators showed marked antiproliferative activity as well as cytotoxicity toward myeloma cell lines and deferasirox was cytotoxic to bone marrow plasma...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2014.06.005
更新日期：2014-08-01 00:00:00
abstract：:Essential thrombocythemia (ET) is an uncommon chronic myeloproliferative disorder with no cure. Patients with ET are at risk of different complications, and currently there are no optimal prognostic standards to predict severe post-diagnosis complications such as thrombosis and hemorrhage. In this study, we retrospect...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2018.03.013
更新日期：2018-06-01 00:00:00
abstract：:The hotspot c.7541_7542delCT NOTCH1 mutation has been proven to have a negative clinical impact in chronic lymphocytic leukemia (CLL). However, an optimal method for its detection has not yet been specified. The aim of our study was to examine the presence of the NOTCH1 mutation in CLL using three commonly used molecu...
journal_title：Leukemia research
pub_type： 杂志文章
doi：10.1016/j.leukres.2017.08.001
更新日期：2017-09-01 00:00:00
