Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia.

Abstract:

:Discovering genetic predictors of childhood acute lymphoblastic leukemia (ALL) necessitates the evaluation of novel factors including maternal genetic effects, which are a proxy for the intrauterine environment, and robust epidemiologic study designs. Therefore, we evaluated five maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood ALL among 120 case-parent triads. Two of the five haplotypes were significantly associated with risk: GSTM3/GSTM4 (P=0.01) and GSTP1 (P=0.02). The EPHX1 haplotype was marginally associated with risk (P=0.05), whereas haplotypes in CYP1B1 and GSTA4 were not. Our results suggest genetic variation in xenobiotic metabolism is important in childhood ALL etiology.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Nousome D,Lupo PJ,Okcu MF,Scheurer ME

doi

10.1016/j.leukres.2013.01.020

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

531-5

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(13)00036-2

journal_volume

37

pub_type

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