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Combination therapy with arsenic trioxide, all-trans retinoic acid, and chemotherapy in acute promyelocytic leukemia patients with various relapse risks.

Abstract：

:To improve the recovery rate of high-risk patients with acute promyelocytic leukemia (APL), we used all-trans retinoic acid (ATRA)/arsenic trioxide (ATO)/daunorubicin combination in remission induction, daunorubicin and cytarabine in consolidation, and ATRA/ATO/methotrexate ± 6-mercaptopurine in maintenance treatment of APL patients with various risks for relapse. Our results showed a high complete remission rate of 95.3%. Excluding the cases of early-death, no significant differences in event-free survival were observed between the intermediate-risk and high-risk group (p = 0.393) and the low-risk and high-risk group (p = 0.162). In addition, there were no significant differences between the groups in cumulative incidence of central nervous system relapse. In conclusion, our results suggest that APL patients benefit from combination ATO/ATRA/chemotherapy, and that this regimen is especially beneficial for patients with high-risk prognostic factors.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Huang H,Qin Y,Xu R,You X,Teng R,Yang L,Xu M,Liu H

doi

10.1016/j.leukres.2012.03.027

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

841-5

issue

7

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(12)00172-5

journal_volume

36

pub_type

杂志文章

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