当前位置： SCI文献检索 > LEUKEMIA RESEARCH期刊下所有文献 > Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.

Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.

Abstract：

:Although verapamil, cyclosporin A. cremophor EL and PSC-833 are active as multidrug resistance modulators, there has been limited study of these compounds as possible chemotherapy enhancing agents against drug-sensitive tumors. We compared these agents as modifiers of VP-16 cytotoxicity in vitro and modifiers of VP-16 efficacy in vivo against drug-sensitive P388 and L1210 leukemias. Our study indicates that cyclosporin A enhances VP-16 cytotoxicity to a significantly greater extent than equimolar concentrations of verapamil or PSC-833. Although cremophor EL shows significantly greater activity than verapamil in VP-16 cytotoxicity enhancement in vitro, it is ineffective when added to VP-16 therapy of mice bearing L1210 leukemia.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Slater L,Sweet P,Wetzel M,Stupecky M,Osann K

doi

10.1016/0145-2126(95)00029-n

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

543-8

issue

8

eissn

0145-2126

issn

1873-5835

pii

014521269500029N

journal_volume

19

pub_type

杂志文章

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