Infectious feline leukaemia virus is erythrosuppressive in vitro.

abstract：:Our aim was to examine in 17 patients with MDS the effects of PMA activated and non-activated autologous lymphocytes on selected bone marrow CD34+ progenitors, in dose response studies. We used a double layer culture technique. Compared with controls, there was no difference in the colony growth promoting capacity of ...

journal_title：Leukemia research

authors： Davison GM,Novitzky N,Abdulla R

更新日期：2011-09-01 00:00:00

abstract：:The efficiency of gene transfer into human leukemia cell lines by electroporation was investigated. For both transient expression (beta-galactosidase gene) and stable transformation (neomycin resistance gene), the transfer efficiency into leukemia cell lines using a square wave pulse was superior to that using an expo...

journal_title：Leukemia research

authors： Takahashi M,Furukawa T,Saitoh H,Aoki A,Koike T,Moriyama Y,Shibata A

更新日期：1991-01-01 00:00:00

abstract：:To determine the role of cell-mediated immunity (CMI) to cytomegalovirus (CMV) in leukemic children after CMV infection, CMI to CMV antigen was studied using CMV-specific lymphocyte blastogenic responses (LBR) and interferon (IFN) production. Four children, who continuously secreted CMV in urine more than 2 years afte...

journal_title：Leukemia research

authors： Ihara T,Yasuda N,Isaji M,Torigoe S,Ito M,Kamiya H,Sakurai M

更新日期：1994-07-01 00:00:00

abstract：:The mechanism of the inhibition of proliferation of human leukaemia 60 (HL60) cells by S-D-lactoylglutathione in vitro was investigated. The median inhibitory concentration IC50 value was 66 microM (95% C.I. 50-87 microM; n = 18). The inhibition of leukaemia cell growth required exposure of HL60 cells to S-D-lactoylgl...

journal_title：Leukemia research

authors： Edwards L,Clelland JD,Thornalley PJ

更新日期：1993-04-01 00:00:00

abstract：:Determination of T-cell clonality has an important additional value for diagnosis of T-cell lymphomas. Various molecular methods have been developed, including polymerase chain reaction (PCR) of T-cell receptor γ (TCRγ). The detection of PCR products usually relies commonly on either GeneScan (GS) analysis or heterodu...

journal_title：Leukemia research

authors： Beaufils N,Ben Lassoued A,Essaydi A,Dales JP,Formisano-Tréziny C,Bonnet N,Grob JJ,Gabert J

更新日期：2012-09-01 00:00:00

abstract：:Ten patients with acute nonlymphocytic leukemia (ANLL) received bromodeoxyuridine (BrdU) at 100 mg/M2 intravenously over 1 h. BrdU is incorporated into the DNA by S-phase cells and was detected by using a monoclonal anti-BrdU antibody in the bone marrow aspirate (BM) and biopsy specimens obtained at the end of the inf...

journal_title：Leukemia research

authors： Raza A,Maheshwari Y,Yasin Z,Mandava N,Mayers G,Preisler HD

更新日期：1987-01-01 00:00:00

abstract：:Appropriate treatment for nonreactive thrombocytosis resulting from a myeloproliferative disorder (MPD) is surrounded by controversy. Although few doubt the association of thrombocytosis with increased risk for life-threatening events such as thrombosis or hemorrhage, or the association between clonal myeloproliferati...

journal_title：Leukemia research

authors： Fruchtman SM,Petitt RM,Gilbert HS,Fiddler G,Lyne A,Anagrelide Study Group.

更新日期：2005-05-01 00:00:00

abstract：:We used fluorescence in situ hybridization (FISH) assays to identify t(14;18) translocations in archival paraffin-embedded tumor sections from non-Hodgkin lymphoma (NHL) cases enrolled in a population-based study. t(14;18) was identified in 54% of 152 cases, including 39% of diffuse large cell lymphomas (26 of 66 case...

journal_title：Leukemia research

authors： Chang CM,Schroeder JC,Huang WY,Dunphy CH,Baric RS,Olshan AF,Dorsey KC,Dent GA,Cerhan JR,Lynch CF,Rothman N,Cantor KP,Blair A

更新日期：2010-02-01 00:00:00

abstract：:We have previously reported that serum stem factor (SCF) levels are significantly lower in patients with myelodysplastic syndrome (MDS) than normal controls. We have now studied the effects of adding SCF to cultures of blood mononuclear cells from patients with MDS and normal subjects. Three of 17 patients with MDS sh...

journal_title：Leukemia research

authors： Masters GS,Baines P,Tang C,Bowen D,Burnett AK

更新日期：1995-08-01 00:00:00

abstract：:Dose reductions or interruptions may be required to manage treatment-associated adverse events among patients with myelodysplastic syndromes (MDS) treated with lenalidomide; such modifications are recommended to sustain therapy and maximize treatment duration. The aim of this retrospective case-control study was to de...

journal_title：Leukemia research

authors： DeZern AE,Binder G,Ni Q,McGuire M,Smith BD

更新日期：2017-12-01 00:00:00

abstract：:In AML, prevention of GvHD leads to better tolerance of myeloablative therapy. 66 individuals with AML in CR underwent myeloablative conditioning and transplantation with allogeneic PBPC grafts. Median presentation age was 44.5 years. Karyotyping was intermediate in 48% and of unfavourable risk in 36%. For GvHD prophy...

journal_title：Leukemia research

authors： Novitzky N,Thomas V

更新日期：2012-01-01 00:00:00

abstract：:Peripheral blood and/or bone marrow lymphoblasts from 25 patients with acute lymphoblastic leukemia (ALL) were tested with a panel of monoclonal antibodies (MoAbs) and conventional hematopoietic markers by three different laboratories. The results were analysed to evaluate the reproducibility of ALL phenotype determin...

journal_title：Leukemia research

authors： Sobol RE,Mick R,LeBien TW,Ozer H,Minowada J,Anderson K,Ellison RR,Cuttner J,Morrison A,Richards F 2nd

更新日期：1986-01-01 00:00:00

abstract：:We compared the efficacy and toxicity of BEAM (BCNU, etoposide, cytarabine and melphalan) and BuCyE (busulfan, cyclophosphamide and etoposide), given prior to autologous stem cell transplantation (ASCT), in 65 patients with non-Hodgkin's lymphoma. Of these 65 patients, 43 received BEAM and 22 received BuCyE. Their age...

journal_title：Leukemia research

authors： Kim JE,Lee DH,Yoo C,Kim S,Kim SW,Lee JS,Park CJ,Huh J,Suh C

更新日期：2011-02-01 00:00:00

abstract：:Hodgkin and Sternberg Reed (H and SR) cells, the putative malignant cells of Hodgkin's disease carry regularly T-cell activation antigens, like CD30 and CD25 (low affinity IL-2 receptor). We have investigated the Hodgkin cell line L540, bearing characteristic markers of H and SR cells for its expression of the low aff...

journal_title：Leukemia research

authors： Tesch H,Herrmann T,Abts H,Diamantstein T,Diehl V

更新日期：1990-01-01 00:00:00

abstract：:Nucleic acid and protein synthesis was determined in immature myeloid cells isolated from seven normal bone marrow samples and compared to blasts from nine patients with fullblown acute non-lymphocytic leukemia. Samples obtained from normal bone marrow contained a mean of 82% immature myeloid cells with 29.9% S-phase ...

journal_title：Leukemia research

authors： Burghouts JT,Plas AM,Salden MH,Wessels HM

更新日期：1982-01-01 00:00:00

abstract：:We have isolated an M-CSF-like membrane-associated growth factor from human leukemic J6-1 cells that can enhance the growth and colony formation of J6-1 cells in vitro. Indirect evidence suggests that this membrane-associated M-CSF-like growth factor may do so by stimulating a corresponding receptor co-expressed on th...

journal_title：Leukemia research

authors： Wu KF,Rao Q,Zheng GG,He ZH,Ying HG,Song YH,Chen BD

更新日期：1998-01-01 00:00:00

abstract：:The effect of prostaglandin E2 (PGE2) on the reduction of c-myc expression during the differentiation of the human leukemic cell line, HL-60, was examined. PGE2, a potent inducer of intracellular cyclic AMP (cAMP) in HL-60 cells, augmented monocyte-associated cell surface antigens induced by human gamma-interferon (IF...

journal_title：Leukemia research

authors： Matsui T,Nakao Y,Koizumi T,Katakami Y,Takahashi R,Mihara K,Sugiyama T,Fujita T

更新日期：1988-01-01 00:00:00

abstract：:Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxicity in human acute promyelocytic leukemia NB4 cells by early disturbance in mitochondrial function and oxidative stres...

journal_title：Leukemia research

authors： García-Pérez AI,Galeano E,Nieto E,Estañ MC,Sancho P

更新日期：2014-07-01 00:00:00

abstract：:The in-vitro effects of deoxycoformycin (dCF) on dATP, NAD, ATP and DNA strand breaks have been evaluated in the cells from 42 patients with various types of chronic lymphoid leukemia. These included 18 with B-cell chronic lymphoid leukemias of different types (BCL); 10 with hairy cell leukemia (HCL) and 14 with T-cel...

journal_title：Leukemia research

authors： Ganeshaguru K,Ho AD,Piga A,Catovsky D,Hoffbrand AV

更新日期：1987-01-01 00:00:00

abstract：:Gain-of-function mutations in the proto-oncogene c-kit that induce constitutive kinase activity of its product, KIT protein, are characteristic of human mast cell disease and are believed to play a central role in mast cell leukemia oncogenesis, proliferation and survival. Nuclear overexpression of the Wnt effector be...

journal_title：Leukemia research

authors： Kajiguchi T,Lee S,Lee MJ,Trepel JB,Neckers L

更新日期：2008-05-01 00:00:00

abstract：:Magnetic resonance provides a non-invasive tool for monitoring normal and leukemic bone marrow. Measurements of the T1 relaxation times are elevated in acute myelogenous leukemia. However, interpatient variability diminishes the usefulness of MR measurements for diagnosing leukemia. In following the time course of ind...

journal_title：Leukemia research

authors： Henkelman RM,Messner H,Poon PY,Hinks RS,Stewart C,Curtis J,Minden M,Baker M

更新日期：1988-01-01 00:00:00

abstract：:Granulocytic sarcoma (GS) is a rare extra-medullary tumor and usually involves the skin, soft tissue, and lymph nodes. GS is found in 8% of acute myeloid leukemia (AML) patients, especially patients with t(8;21)AML. It has been suggested that GS is a poor prognostic factor in t(8;21)AML. Compared to t(8;21)AML, GS is ...

journal_title：Leukemia research

authors： Fujieda A,Nishii K,Tamaru T,Otsuki S,Kobayashi K,Monma F,Ohishi K,Nakase K,Katayama N,Shiku H

更新日期：2006-08-01 00:00:00

abstract：:To examine the relationship between viability of acute myelogenous leukemia (AML) blasts in liquid suspension culture and the occurrence of myeloid maturation in culture, total and differential cell counts and viability as determined by trypan blue dye exclusion were followed over 21 days of culture. A significant pos...

journal_title：Leukemia research

authors： Baer MR,Gao XZ,Preisler HD

更新日期：1988-01-01 00:00:00

abstract：:This study investigated radioresistance mechanisms in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100. AML-2/DX100 also showed resistance to radiation. AML-2/DX100 characterized by down-regulated catalase expression was supersensitive to exogenous hydrogen peroxide whereas they increased defense mec...

journal_title：Leukemia research

authors： Choi CH,Xu H,Bark H,Lee TB,Yun J,Kang SI,Oh YK

更新日期：2007-09-01 00:00:00

abstract：:MDS is primarily a disease of the elderly. Cases who give a history of exposure to X-rays, cytotoxic drugs or leukaemogenic chemicals may be younger. Many cases of MDS present because of an incidental blood count. The most prominent clinical features are those of anaemia, neutropenia, thrombocytopenia. Because haemopo...

journal_title：Leukemia research

authors： Hamblin T

更新日期：1992-01-01 00:00:00

abstract：:We evaluated the molecular mechanism of telomerase activation by erythropoietin (EPO) in human erythroleukemic JAS-REN-A cells. Telomerase activity increased 3-4 fold after 3-24h of culture with EPO and was associated with increases in c-myc mRNA after 1-3h, of c-Myc protein after 3-6h, and of human telomerase reverse...

journal_title：Leukemia research

authors： Akiyama M,Kawano T,Mikami-Terao Y,Agawa-Ohta M,Yamada O,Ida H,Yamada H

更新日期：2011-03-01 00:00:00

abstract：:Survivin is a newly discovered inhibitor of the apoptosis protein, IAP, expressed during development and in human cancers. The effector cell protease receptor-1 (EPR-1) gene is oriented in the opposite direction on the same DNA double strand. Thus, the Survivin and EPR-1 (Survivin/EPR-1) genes exist in a head-to-head ...

journal_title：Leukemia research

authors： Shinozawa I,Inokuchi K,Wakabayashi I,Dan K

更新日期：2000-11-01 00:00:00

abstract：:The colony-forming capacity of the peripheral blood stem/progenitor cells (PBSC) in different forms of myelodysplastic syndrome (MDS) was investigated. In most cases of refractory anemia (RA) the colony growth of PBSC was definitely reduced as compared to the controls. However, in RA with unfavorable chromosomal aberr...

journal_title：Leukemia research

authors： Vehmeyer K,Haase D,Alves F

更新日期：2001-11-01 00:00:00

abstract：:Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late C...

journal_title：Leukemia research

authors： Breccia M,Cannella L,Stefanizzi C,Santopietro M,De Cuia R,Diverio D,Alimena G

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND/AIMS:Jumping translocations are rare cytogenetic aberrations in haematological malignancies, the pathogenesis of which remains to be fully characterised. We investigated the mechanism of formation of jumping translocations in a case of adult common acute lymphoblastic leukaemia (ALL) positive for the Ph tran...

journal_title：Leukemia research

authors： Wan TS,Ma SK,Chow EY,Li YH,Lin SY,Chan LC

更新日期：2004-10-01 00:00:00