Balance of NF-kappaB and p38 MAPK is a determinant of radiosensitivity of the AML-2 and its doxorubicin-resistant cell lines.

abstract：:We report a case of Ph1-negative, bcr-negative CML-BC, in which the primary leukemic cells displayed T-related antigens (CD7, CD4) in addition to HLA-DR and CD25 determinants. No B-lymphoid, myeloid and megakaryoblastic surface antigens were detected. In spite of this phenotype, DNA analysis revealed a germ-line confi...

journal_title：Leukemia research

authors： Callea V,Morabito F,Lista P,Pegoraro L,Cambrin GR,Guerrasio A,Saglio G,Tassinari A,Fierro MT,Iacopino P

更新日期：1988-01-01 00:00:00

abstract：:Zerumbone (ZER) is a potential anticancer natural compound, isolated from Zingiber zerumbet Smith. In this investigation, the anticancer properties of ZER were evaluated on cancer cells of T-acute lymphoblastic leukemia, CEM-ss. The results showed that ZER has cytotoxic effect against CEM-ss cells with an IC(50) of 8....

journal_title：Leukemia research

authors： Abdelwahab SI,Abdul AB,Mohan S,Taha MM,Syam S,Ibrahim MY,Mariod AA

更新日期：2011-02-01 00:00:00

abstract：:We describe the properties of three monoclonal antibodies (McAbs) (21H73, 37G7 and 49C12) against K562 cell surface antigens correlated with differentiation induced by 12-O-tetradecanoyl phorbol-13-acetate (TPA). Each of the McAbs immunoprecipitated K562 cell surface antigen with molecular weight (MW) of approximately...

journal_title：Leukemia research

authors： Kubota Y,Tanaka T,Irino S

更新日期：1991-01-01 00:00:00

abstract：:Reversal of drug resistance is of pivotal importance in order to improve the results of chemotherapy. Monitoring of such reversal is necessary in order to analyze the results of clinical trials. Nonetheless, the leukemia cell population to eradicate is the leukemia initiating cells characterized by a CD34+CD38- phenot...

journal_title：Leukemia research

authors： Costello RT

更新日期：2009-06-01 00:00:00

abstract：:The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffus...

journal_title：Leukemia research

authors： Boelens J,Jais JP,Vanhoecke B,Beck I,Van Melckebeke H,Philippé J,Bracke M,Jardin F,Brière J,Leroy K,Offner F,Lust S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:Multiple myeloma patients may develop extraosseous involvement in the course of the disease making prognosis very poor and new drugs clearly needed. The PD-1/PD-L1 axis has emerged as a master immune checkpoint in antitumor responses and recent studies investigated the role of PD-L1 in multiple myeloma cells; no data ...

journal_title：Leukemia research

authors： Crescenzi A,Annibali O,Bianchi A,Pagano A,Donati M,Grifoni A,Avvisati G

更新日期：2016-10-01 00:00:00

abstract：:Activating mutations or over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), associated with activation of Ras/MAP kinase and other signaling pathways. In this study, we addressed the role of Flt3 in the activation of nuclear factor-kappa B (NF-kappaB), which is a target molecule of these kin...

journal_title：Leukemia research

authors： Takahashi S,Harigae H,Ishii KK,Inomata M,Fujiwara T,Yokoyama H,Ishizawa K,Kameoka J,Licht JD,Sasaki T,Kaku M

更新日期：2005-08-01 00:00:00

abstract：:microRNA profiling of acute myeloid leukemia patient samples identified miR-125a as being decreased. Current literature has investigated miR-125a's role in normal hematopoiesis but not within acute myeloid leukemia. Analysis of the upstream region of miR-125a identified several CpG islands. Both precursor and mature m...

journal_title：Leukemia research

authors： Ufkin ML,Peterson S,Yang X,Driscoll H,Duarte C,Sathyanarayana P

更新日期：2014-03-01 00:00:00

abstract：:Five patients from the Kyushu area in Japan with adult T-cell leukaemia (ATL) refractory to conventional chemotherapeutic agents were treated with 5 mg/m2 of the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF), intravenously (i.v.) for 3 consecutive days, followed by 5 mg/m2 i.v. weekly. Two patients showed a ...

journal_title：Leukemia research

authors： Yamaguchi K,Yul LS,Oda T,Maeda Y,Ishii M,Fujita K,Kagiyama S,Nagai K,Suzuki H,Takatsuki K

更新日期：1986-01-01 00:00:00

abstract：:Mononuclear cells from a bone marrow infiltrated by plasmacytoma cells were examined by electron microscopy. An analysis was performed according to different cytoarchitectural forms of the endoplasmic reticulum (ER). Six types of plasma cells could be distinguished. The bone marrow cells were treated with an anti-idio...

journal_title：Leukemia research

authors： Renau-Piqueras J,Wetter O,Miragall F,Brandhorst D,Martinez-Ramon A

更新日期：1984-01-01 00:00:00

abstract：:Among 17,633 U.S. white male insurance policy holders whose use of tobacco was characterized in a 1966 self-administered questionnaire, there were 49 deaths from non-Hodgkin's lymphoma (NHL) and 21 from multiple myeloma (MM) during a 20-year follow-up. Men who had ever smoked cigarettes had an elevated mortality from ...

journal_title：Leukemia research

authors： Linet MS,McLaughlin JK,Hsing AW,Wacholder S,Co Chien HT,Schuman LM,Bjelke E,Blot WJ

更新日期：1992-06-01 00:00:00

abstract：:The thymic stroma has long been implicated in AKR thymic leukaemia. In this study an extensive panel of monoclonal antibodies was used to investigate changes in the AKR thymic microenvironment, in parallel with thymocyte differentiation of normal (2 month), preleukaemic (5-7 month) and leukaemic (> 7 month) mice. We f...

journal_title：Leukemia research

authors： Davey GM,Tucek-Szabo CL,Boyd RL

更新日期：1996-10-01 00:00:00

abstract：:miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleuk...

journal_title：Leukemia research

authors： Kaddar T,Chien WW,Bertrand Y,Pages MP,Rouault JP,Salles G,Ffrench M,Magaud JP

更新日期：2009-09-01 00:00:00

abstract：:The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox propo...

journal_title：Leukemia research

authors： Gupta S,Sutradhar R,Guttmann A,Sung L,Pole JD

更新日期：2014-12-01 00:00:00

abstract：:A total of 854 patients with anti-HTLV-I antibody positive ATL, newly diagnosed from 1983 to 1987, were analyzed for prognostic factors. There were 466 males and 388 females with a mean age of 57.1. Of these 269 (31.5%) were alive with a median follow-up time of 14 months from diagnosis, while 585 (65.5%) were dead wi...

journal_title：Leukemia research

authors：

更新日期：1991-01-01 00:00:00

abstract：:Allogeneic stem cell transplantation is considered to be a curative treatment modality in patients with chronic myelogenous leukemia. However patients are at risk for relapse years after transplantation. Currently we present two patients who relapsed 16 and 24 years after allogeneic bone marrow transplantation, respec...

journal_title：Leukemia research

authors： Sekhri A,Liu D,Rasul M,Ahmed N,Ahmed T,Seiter K

更新日期：2009-09-01 00:00:00

abstract：:Platelet transfusion refractoriness (PTR) is a major adverse event in the management of acute myeloid leukemia (AML). In a series of 897 adult patients with AML receiving intensive chemotherapy, we identified 41 patients (4.8%) with PTR. PTR was more frequently observed in parous women, patients with extra-medullary d...

journal_title：Leukemia research

authors： Comont T,Tavitian S,Bardiaux L,Fort M,Debiol B,Morère D,Bérard E,Delabesse E,Luquet I,Martinez S,Huguet F,Récher C,Bertoli S

更新日期：2017-10-01 00:00:00

abstract：:The mechanism of the inhibition of proliferation of human leukaemia 60 (HL60) cells by S-D-lactoylglutathione in vitro was investigated. The median inhibitory concentration IC50 value was 66 microM (95% C.I. 50-87 microM; n = 18). The inhibition of leukaemia cell growth required exposure of HL60 cells to S-D-lactoylgl...

journal_title：Leukemia research

authors： Edwards L,Clelland JD,Thornalley PJ

更新日期：1993-04-01 00:00:00

abstract：:The resistance to all trans retinoic acid (ATRA) differentiating treatment is a consequence, in most of the cases, of either increased catabolism or down regulation of ATRA uptake. Recently, we have shown that ATRA efficiency to differentiate HL-60 cells was enhanced about 30 times after its incorporation into Low Den...

journal_title：Leukemia research

authors： Gueddari N,Madoulet C,Lefebvre P,Berthou L,Chomienne C,Jardillier JC

更新日期：2000-06-01 00:00:00

abstract：:Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. We report here that OPN gene is transactivated by Tax protein of human T-cell leukemia virus type 1 (HTLV-1). Northern blot showed enhanced OPN gene expression in cells stably expressing Tax....

journal_title：Leukemia research

authors： Zhang J,Yamada O,Matsushita Y,Chagan-Yasutan H,Hattori T

更新日期：2010-06-01 00:00:00

abstract：:Despite advances in understanding the complexities of acute myeloid leukaemia (AML), the treatment of refractory or relapsed AML (rrAML) remains a daunting clinical challenge. Numerous clinical trials have failed to identify new treatments or combinations of existing therapies that substantially improve outcomes and s...

journal_title：Leukemia research

authors： Kell J

更新日期：2016-08-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Although several clinical characteristics can be associated with worse prognosis, more robust biological markers still remains uncovered. SMYD2, a member of SMYD protein family, regulates the activity of several proteins through methylation. I...

journal_title：Leukemia research

authors： Sakamoto LH,Andrade RV,Felipe MS,Motoyama AB,Pittella Silva F

更新日期：2014-04-01 00:00:00

abstract：:A combination of monosomy 7 and translocation t(9;22) (q34;q11), rarely observed in acute lymphoblastic leukaemia (ALL), is here reported: a peculiarity of this case was that the "breakpoint cluster region" on chromosome 22 was not rearranged, as demonstrated by molecular analysis, and a new c-abl protein (p190) was f...

journal_title：Leukemia research

authors： Eridani S,Gorman P,Sheer D,Duncombe AS,Glass UH,Shivji MK

更新日期：1987-01-01 00:00:00

abstract：:Osteogenic growth peptide (OGP) is a peptide exerting regulatory effects on the bone and on bone marrow. The carboxy-terminal pentapeptide (OGP10-14) is the biologically active portion of OGP. We evaluated OGP10-14 hematopoietic activity performing colony-forming tests on human stem cells derived by bone marrow, perip...

journal_title：Leukemia research

authors： Fazzi R,Galimberti S,Testi R,Pacini S,Trasciatti S,Rosini S,Petrini M

更新日期：2002-09-01 00:00:00

abstract：:Medullary dyserythropoiesis with reduced production of erythrocytes is an early and consistent feature of myelodysplastic syndromes (MDS). The mechanism underlying the disturbed red cell proliferation and maturation is presently unknown. In order to study the role of erythropoietic growth factors, we determined by rad...

journal_title：Leukemia research

authors： Aul C,Arning M,Runde V,Schneider W

更新日期：1991-01-01 00:00:00

abstract：:Information about the expression of some myelomonocytic markers in lymphocytes of patients with B-CLL is scarce. We studied the CD13, CD14, CD11c and CD68 surface antigens in 42 controls and in 38 patients with B-CLL to detect their possible reactivity. Eighty-nine percent of B-CLL expressed very strongly the CD14 ant...

journal_title：Leukemia research

authors： Woessner S,Florensa L,Besses C,Vilà RM,Gallés C,Palou L,Sabrafen JS

更新日期：1992-01-01 00:00:00

abstract：:The genes for the CDK4/6-inhibitors p16INK4A/MTS1 and p15INK4B/MTS2 are frequently deleted in hematological malignancies. A new member of this family of CDK4/6 inhibitors is p18. In order to assess p18 growth-suppressor gene alterations in hematological neoplasms, we investigated 31 lymphoma and leukemia cell lines by...

journal_title：Leukemia research

authors： Siebert R,Willers CP,Fosså A,Kloke O,Nowrousian MR,Seeber S,Opalka B

更新日期：1996-02-01 00:00:00

abstract：:Thirty patients with high-risk myelodysplastic syndrome, defined as > 5% bone marrow blasts, were treated with a combination of oral all-trans-retinoic acid (45 mg/m2 daily) and subcutaneous AraC (10 mg/m2) on days 1-14 of each 28-35 day cycle repeated for 2-6 cycles. Complete remission lasting 9, 12, and 15 months wa...

journal_title：Leukemia research

authors： Letendre L,Noel P,White WL,Tefferi A,Litzow MR,Li CY,Schroeder G

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:The skin is the common extranasal sites in extranodal natural killer (NK) / T - cell lymphoma, (ENKTL). However, data regarding cutaneous ENKTL are relatively scarce. Thus, we performed a large retrospective study to analyze clinical features and treatment outcomes of cutaneous ENKTL. PATIENTS AND METHODS:S...

journal_title：Leukemia research

authors： Jiang L,Li P,Quan Q,Chen P,Qiu H,Zhang B

更新日期：2020-01-01 00:00:00