Abstract:
:Platelet transfusion refractoriness (PTR) is a major adverse event in the management of acute myeloid leukemia (AML). In a series of 897 adult patients with AML receiving intensive chemotherapy, we identified 41 patients (4.8%) with PTR. PTR was more frequently observed in parous women, patients with extra-medullary disease, a low white blood cell count, an infection, or hemophagocytic syndrome. Among the 31 patients with anti-human leucocyte antigen (HLA) antibodies, an HLA-matched donor was identified for 18 patients (58.1%). Median time between diagnosis of PTR and the first HLA-matched transfusion was 12.5days. HLA-matched transfusions induced a significant increment in platelet counts in 37% of cases. Thrombopoietin receptor agonists were given to 10 patients but did not shorten the duration of thrombocytopenia, reduce severe bleeding, or early death. Grade 3-4 bleeding events during induction, early death caused by bleeding, and death caused by bleeding at any time were significantly greater in patients that had platelet transfusion refractoriness (22% vs. 4.1%, P<0.0001; 12.2% vs. 1.4%, P=0.0006; and 24.4% vs. 5.3%, P<0.0001; respectively). PTR during chemotherapy for AML significantly increased the risk of early and late deaths caused by a severe bleeding event. Improved understanding of platelet destruction is needed to design mechanism-based therapeutic strategies.
journal_name
Leuk Resjournal_title
Leukemia researchauthors
Comont T,Tavitian S,Bardiaux L,Fort M,Debiol B,Morère D,Bérard E,Delabesse E,Luquet I,Martinez S,Huguet F,Récher C,Bertoli Sdoi
10.1016/j.leukres.2017.08.015subject
Has Abstractpub_date
2017-10-01 00:00:00pages
62-67eissn
0145-2126issn
1873-5835pii
S0145-2126(17)30496-4journal_volume
61pub_type
杂志文章abstract::Leukaemic cells from the peripheral blood of 90 patients with acute leukaemia (54 non-lymphocytic (ANLL) 36 lymphocytic (ALL)) have been examined for the presence of the platelet/ALL-associated p24 membrane antigen by indirect immunofluorescence and flow cytometry using monoclonal antibody FMC8. Cells from 28 of the A...
journal_title:Leukemia research
pub_type: 杂志文章
doi:10.1016/0145-2126(87)90109-3
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abstract::Aberrant promoter methylation may contribute to the hematopoietic disturbances in myelodysplastic syndromes (MDS). To explore a possible mechanism, we therefore analyzed expression of DNA methyltransferase (DNMT) subtypes kinetics and aberrant promoter methylation of key regulatory genes during MDS hematopoiesis. An i...
journal_title:Leukemia research
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journal_title:Leukemia research
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abstract::Secondary acute lymphoblastic leukemia (s-ALL) is rare and poorly defined and data regarding outcomes post-transplant are lacking. Here, we report a detailed analysis of s-ALL at our Institution. Among 211 eligible patients with ALL from 2006 to 2017, 30 (14%) were defined as s-ALL and the remaining as primary ALL (p-...
journal_title:Leukemia research
pub_type: 杂志文章,meta分析,评审
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abstract:PURPOSE:The study aims to develop a prognostic scoring system based on prognostic lncRNAs for acute myeloid leukemia (AML). METHODS:Based on lncRNA expression profiles downloaded from The Cancer Genome Atlas (TCGA), differentially expressed long noncoding RNAs (DELs) between good prognosis and bad prognosis samples we...
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journal_title:Leukemia research
pub_type: 杂志文章,随机对照试验
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abstract:OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...
journal_title:Leukemia research
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journal_title:Leukemia research
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journal_title:Leukemia research
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doi:10.1016/j.leukres.2009.12.008
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 信件
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更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Leukemia research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Leukemia research
pub_type: 杂志文章
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abstract::Radiotherapy (RT)is considered the treatment of choice in patients with Extra-nodal marginal zone lymphoma (EMZL) at early stage, but the presence of late toxicities has been limited the acceptance. Recently, low doses of RT LDR) (2 x 2 Gy) and the use of limited fields has been observed that retain the efficacy but e...
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pub_type: 临床试验,杂志文章
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