Telomere length, c-myc and mad-1 expression could represent prognosis markers of myelodysplastic syndrome.

Abstract:

:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) and in controls (n=24). TL was lower in MDS patients than in controls (p<0.001) and higher in L-MDS (low, intermediate-1 IPSS, p<0.01) respect H-MDS (high, intermediate-2 IPSS, p<0.01) patients. Mad-1 expression was higher in MDS patients than in controls (p<0.01), c-myc expression was highest in AML and in H-MDS patients. Our results show that the telomere dynamics might be useful for stratifying patients according to a risk scoring system.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Poloni A,Serrani F,Berardinelli E,Maurizi G,Mariani M,Costantini B,Trappolini S,Mancini S,Olivieri A,Leoni P

doi

10.1016/j.leukres.2013.07.022

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1538-44

issue

11

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(13)00249-X

journal_volume

37

pub_type

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