Expression of the non-T ALL-associated p24 antigen on leukaemic blasts from patients with ANLL.

abstract：:We analysed the optimal conditions for autologous bone marrow purging using complement binding monoclonal antibodies (mAbs). Twelve mAbs belonging to four clusters (CD9, CD10, CD19, CD24), alone or combined were evaluated by using direct cytotoxicity and clonogenic assays. We observed the following data: (1) optimal c...

journal_title：Leukemia research

authors： Racadot E,Herve P,Lamy B,Peters A

更新日期：1987-01-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) cells were cultured in a medium supplemented with 0.01-1 ng/ml interleukin-4 (IL-4) for 18 h, fixed and analyzed on a flow cytometer. The percentage of apoptotic (AP) cells with hypodiploid DNA content was determined from DNA histograms. IL-4 at 0.01 ng/ml protected from spontaneous ...

journal_title：Leukemia research

authors： Frankfurt OS,Byrnes JJ,Villa L

更新日期：1997-01-01 00:00:00

abstract：:Topotecan has demonstrable activity in high-risk MDS and CMMoL. However, the significant toxicity of topotecan administered at a dose of 2mg/m2 i.v. daily for 5 days as a continuous infusion limits its use in older patients. Therefore, we studied topotecan 1.5mg/m2 per day i.v. over 2 h for three consecutive days in 2...

journal_title：Leukemia research

authors： Vaena DA,Walker P,Pennington K,Stephens A,Stender MJ,Yiannoutsos CT,Young C,Stoner C,Cripe LD,Hoosier Oncology Group.

更新日期：2004-01-01 00:00:00

abstract：:We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported with prolonged chemotherapy mode...

journal_title：Leukemia research

authors： Sotomayor EM,Piantadosi S,Miller CB,Karp JE,Jones RJ,Rowley SD,Kaufmann SH,Braine H,Burke PJ,Gore SD

更新日期：2002-05-01 00:00:00

abstract：:The usefulness of a new method to detect B-cell monoclonality named VR, which is a combination of the digestion with restriction enzymes and vectorette PCR, in aspiration biopsy-nucleic acid diagnosis (ABND) of thyroid malignant lymphoma was investigated. ABND was performed in 12 patients in whom malignant lymphoma wa...

journal_title：Leukemia research

authors： Takano T,Asahi S,Matsuzuka F,Hidaka Y,Yoshida H,Miyauchi A

更新日期：2008-01-01 00:00:00

abstract：:An overview is given of the effects of X-irradiation, ovariohysterectomy and estradiol-17 beta administration on mammary tumorigenesis in females of 3 rat strains, viz. the WAG/Rij, BN/BiRij and SD. The 3 rat strains differed significantly in their spontaneous mammary tumor incidence. Female SD rats had the highest in...

journal_title：Leukemia research

authors： Solleveld HA,van Zwieten MJ,Broerse JJ,Hollander CF

更新日期：1986-01-01 00:00:00

abstract：:Fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGF beta R and NPM/ALK arise from reciprocal chromosomal translocations and cause acute and chronic myelogenous leukemias and non-Hodgkin's lymphoma. Murine hematopoietic growth factor dependent BaF3 cells and cells transformed by FTK (BaF3-FTK) w...

journal_title：Leukemia research

authors： Hoser G,Majsterek I,Romana DL,Slupianek A,Blasiak J,Skorski T

更新日期：2003-03-01 00:00:00

abstract：:Dose reductions or interruptions may be required to manage treatment-associated adverse events among patients with myelodysplastic syndromes (MDS) treated with lenalidomide; such modifications are recommended to sustain therapy and maximize treatment duration. The aim of this retrospective case-control study was to de...

journal_title：Leukemia research

authors： DeZern AE,Binder G,Ni Q,McGuire M,Smith BD

更新日期：2017-12-01 00:00:00

abstract：:Human promyelocytic leukemia cells (HL-60) mature into functional granulocytes in response to in vitro treatment with several classes of chemical agents. Compounds that increase intracellular adenosine 3':5' -cyclic monophosphate induce a modified program of maturation in which the cells demonstrate functional propert...

journal_title：Leukemia research

authors： Chaplinski TJ,Sloan GJ,Niedel JE

更新日期：1985-01-01 00:00:00

abstract：:Introduction of the maturation index (MI) as a measure for the degree of maturation improved the subtyping of acute myeloid leukemia (AML). A comparison is made here between the MI and the results of surface marker analysis with a panel of monoclonal antibodies (McAb) in the immunofluorescence technique. The McAb appl...

journal_title：Leukemia research

authors： van Rhenen DJ,van der Reijden HJ,van't Veer MB,Engelfriet CP,von dem Borne AE,Langenhuijsen MM

更新日期：1983-01-01 00:00:00

abstract：:CD13/aminopeptidase-N, an enzyme expressed by myeloid cells, may be important in the regulation and signalling pathways that control myeloid growth and differentiation. In this study we have used the myeloid leukaemic cell line HL60, and its ability to differentiate when induced by all-trans-retinoic acid (ATRA), to s...

journal_title：Leukemia research

authors： Razak K,Allen PD,Kelsey SM,Gutteridge CN,Newland AC

更新日期：1994-08-01 00:00:00

abstract：:This 5-year, prospective registry enrolled 600 lower-risk MDS patients (pts) with transfusional iron overload. Clinical outcomes were compared between chelated and nonchelated pts. At baseline, cardiovascular comorbidities were more common in non-chelated pts, and MDS therapy was more common in chelated pts. At 24 mon...

journal_title：Leukemia research

authors： Lyons RM,Marek BJ,Paley C,Esposito J,Garbo L,DiBella N,Garcia-Manero G

更新日期：2014-02-01 00:00:00

abstract：:Homeobox genes HOXA9 and MEIS1 are evolutionarily conserved transcription factors with essential roles in both hematopoiesis and leukemogenesis. They act as dominant cooperating oncoproteins that cause acute leukemias bearing MLL translocations and to a lesser extent T-cell acute lymphocytic leukemia (ALL) characteriz...

journal_title：Leukemia research

authors： Adamaki M,Lambrou GI,Athanasiadou A,Vlahopoulos S,Papavassiliou AG,Moschovi M

更新日期：2015-08-01 00:00:00

abstract：:Post-transplant leukemic relapse remains the major problem following autologous bone marrow transplantation (ABMT). One possible approach to reducing the relapse rate is to intensify pre-transplant conditioning. Thiotepa (TTP) is an alkylating agent that has been used mainly in breast and ovarian cancer with 20-50% re...

journal_title：Leukemia research

authors： Nagler A,Finlander R,Or R,Naparstek E,Varadi G,Slavin S

更新日期：1998-11-01 00:00:00

abstract：:As sensitization of leukemia cells with granulocyte colony-stimulating factor (G-CSF) can enhance the cytotoxicity of chemotherapy in myeloid malignancies, a pilot study was conducted in order to evaluate the effect of G-CSF priming combined with low-dose chemotherapy in patients with higher risk myelodysplastic syndr...

journal_title：Leukemia research

authors： Wang FX,Zhang WG,He AL,Cao XM,Chen YX,Zhao WH,Yang Y,Wang JL,Zhang PY,Gu LF

更新日期：2016-09-01 00:00:00

abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

journal_title：Leukemia research

authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

更新日期：2013-05-01 00:00:00

abstract：:Chronic myeloid leukaemia (CML) patients in chronic phase (CP) are currently treated with a standard dose of imatinib of 400mg/daily. However, once in complete cytogenetic remission (CCR) it is possible that some patients maintain this status with reduced dose of the drug. Here, we describe five cases of CML in late C...

journal_title：Leukemia research

authors： Breccia M,Cannella L,Stefanizzi C,Santopietro M,De Cuia R,Diverio D,Alimena G

更新日期：2009-05-01 00:00:00

abstract：:Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease pr...

journal_title：Leukemia research

authors： Wlasiuk P,Stec A,Piechnik A,Kaminska W,Dmoszynska A,Ksiazek A,Giannopoulos K

更新日期：2012-07-01 00:00:00

abstract：:Assessment of treatment response in acute leukemia is routinely performed after therapy via bone marrow biopsy. We investigated the use of positron emission tomography (PET) for early assessment of treatment response in patients with acute myeloid leukemia (AML), using the proliferation marker 3'-deoxy-3'-[(18)F]fluor...

journal_title：Leukemia research

authors： Vanderhoek M,Juckett MB,Perlman SB,Nickles RJ,Jeraj R

更新日期：2011-03-01 00:00:00

abstract：:In order to investigate whether transfer of the cytidine deaminase (CDD) cDNA would increase chemotherapy resistance to cytosine arabinoside (ara-C) we used a retroviral vector expressing both, neomycin phosphotransferase and the CDD cDNA, to transduce hematopoietic cells from cell lines and from murine bone marrow (B...

journal_title：Leukemia research

authors： Flasshove M,Frings W,Schröder JK,Moritz T,Schütte J,Seeber S

更新日期：1999-11-01 00:00:00

abstract：:Ml cells were labeled in vitro with [3H]thymidine and injected into the peritoneal cavity of syngeneic mice. After several days the peritoneal cells were harvested and [3H]labeled cells were determined by autoradiography. The inoculated isotope-labeled Ml cells differentiated in the peritoneal cavity and lipopolysacch...

journal_title：Leukemia research

authors： Honma Y,Hayashi M,Kasukabe T,Hozumi M

更新日期：1982-01-01 00:00:00

abstract：:Dasatinib was approved for the treatment of chronic phase (CP) chronic myeloid leukemia (CML) patients in first line therapy based on the demonstration of efficacy and safety reported in patients enrolled in clinical trials. We describe a multicentric Italian "real-life" experience of dasatinib used as frontline treat...

journal_title：Leukemia research

authors： Breccia M,Stagno F,Luciano L,Abruzzese E,Annunziata M,D'Adda M,Maggi A,Sgherza N,Russo-Rossi A,Pregno P,Castagnetti F,Iurlo A,Latagliata R,Cedrone M,Di Renzo N,Sorà F,Rege-Cambrin G,La Nasa G,Scortechini AR,Greco G

更新日期：2016-01-01 00:00:00

abstract：:Many elderly patients with newly diagnosed acute myeloid leukemia (AML) present with cardiac comorbidity precluding the use of anthracycline containing chemotherapy regimens. Amsacrine, a topoisomerase II inhibitor, has been proposed as possible alternative to anthracyclines. Here, we report about the combination of a...

journal_title：Leukemia research

authors： Kessler T,Mohr M,Müller-Tidow C,Krug U,Brunnberg U,Mohr B,Schliemann C,Sauerland C,Serve H,Büchner T,Berdel WE,Mesters RM

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:Mantle cell lymphoma (MCL) an incurable B-cell, non-Hodgkin lymphoma (NHL) urgently requires new treatments. We assessed reovirus mediated oncolysis in a panel of human MCL cell lines. In vitro, we found the cytopathic effect of reovirus infection ranged from high to very limited and correlated with levels of Ras acti...

journal_title：Leukemia research

authors： Alain T,Muzik H,Otsuka S,Chan S,Magliocco T,Diaz R,Forsyth PA,Morris D,Bebb G

更新日期：2010-01-01 00:00:00

abstract：:The prognostic relevance of 12p deletion is controversial in multiple myeloma (MM) and the status of 12p deletion is unknown in other plasma cell disorders. We investigated 12p deletion in 88 patients with MM, 19 patients with monoclonal gammopathy of undetermined significance (MGUS), and 17 patients with plasma cell ...

journal_title：Leukemia research

authors： Jiang N,Qi C,Yu L,Ning Y,An G,Qiu L,Chang H

更新日期：2012-01-01 00:00:00

abstract：:With Percoll density gradients, blasts from peripheral blood and bone marrow could be separated with a significant enrichment, and very often with a high degree of purity. This allowed a study of selected cases, where the separated sample exhibited chromosome abnormalities and/or an abnormal DNA content distribution (...

journal_title：Leukemia research

authors： Berneman ZN,De Bock R,Van Alsenoy L,Vingerhoets W,Van den Bergh M,Dumon J,Peetermans M

更新日期：1985-01-01 00:00:00

abstract：:The ability of A-MuLV to transform bone marrow cells on in vitro culture in agarose is enhanced by inclusion of conditioned media during infection and culture. The conditioned medium of a non-virus producing A-MuLV transformed fibroblast cell line was synergistic with medium from Whitlock-Witte long-term bone marrow c...

journal_title：Leukemia research

authors： Palumbo GJ,Ozanne B,Kettman JR

更新日期：1991-01-01 00:00:00

abstract：:The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox propo...

journal_title：Leukemia research

authors： Gupta S,Sutradhar R,Guttmann A,Sung L,Pole JD

更新日期：2014-12-01 00:00:00

abstract：:We have analysed the configuration of immunoassociated genes and the karyotypes of 30 patients with acute myelocytic leukemia (AML) and 10 with chronic myelocytic leukemia in blast crisis (CML-BC). In AML, the frequencies of T-cell receptor (TcR) beta, gamma, and delta chain and immunoglobulin heavy and light chain ge...

journal_title：Leukemia research

authors： Akiyoshi TT,Kimura N,Uike N,Kozuru M,Tamura K,Takihara Y,Hisano S,Nishimura J,Kikuchi M

更新日期：1991-01-01 00:00:00