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High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission.

Abstract：

:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-risk cytogenetics, group 1 had a significantly superior DFS (p=0.046), and a trend toward better OS (p=0.087). The treatment group remained a significant predictor of DFS on multivariate analysis. The results indicate that a high-dose cytarabine-containing consolidation regimen produces superior outcomes in AML patients age>60 years with intermediate-risk cytogenetics.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

doi

10.1016/j.leukres.2013.01.001

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

556-60

issue

5

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(13)00005-2

journal_volume

37

pub_type

临床试验,杂志文章

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