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Expression, adverse prognostic significance and therapeutic small molecule inhibition of Polo-like kinase 1 in multiple myeloma.

Abstract：

:The amplified myeloma centrosome has been identified as a therapeutic target. The present study explored the expression and prognostic significance of the centrosome-associated protein PLK1 in myeloma and the effect of BI 2536, a potent and selective inhibitor of PLK1, on myeloma cells. High plasma cell expression of PLK1 protein in myeloma patient bone marrow biopsies is an independent adverse prognostic factor (HR=2.3, p=0.003 unadjusted; HR=1.9, p=0.03 in multivariable model). BI 2536 inhibits myeloma cell lines at nanomolar concentrations, and is therapeutic for xenografts in NOD/SCID mice. PLK1 inhibition is a potential new strategy for the treatment of multiple myeloma.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Evans RP,Dueck G,Sidhu R,Ghosh S,Toman I,Loree J,Bahlis N,Klimowicz AC,Fung J,Jung M,Lai R,Pilarski LM,Belch AR,Reiman T

doi

10.1016/j.leukres.2011.07.016

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1637-43

issue

12

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(11)00359-6

journal_volume

35

pub_type

杂志文章

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