Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia.

Abstract:

:Fluorescent-labeled DNA probes were used to study 52 chronic lymphocytic leukemia (B-CLL) patients for (1) disease progression, (2) angiogenesis genes, (3) T-cell leukemia 1 gene (TCL1), (4) immunoglobulin heavy chain variable region (IGHv) and (5) chromosome 6q. Compared to stable disease, more patients with progressive disease had > or =2 anomalies and a high percentage of neoplastic nuclei. Anomalies of genes for basic fibroblast growth factor, interleukin 4, vascular endothelial growth factor or TCL1 were not detected. Deletions in IGHv occurred in 25% of patients and correlated with IGHv gene expression. Probes for 6q23 detected more deletions in 6q than probes for 6q21.

journal_name

Leuk Res

journal_title

Leukemia research

authors

Fink SR,Paternoster SF,Smoley SA,Flynn HC,Geyer SM,Shanafelt TD,Lee YK,Jelinek DF,Kay NE,Dewald GW

doi

10.1016/j.leukres.2004.07.012

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

253-62

issue

3

eissn

0145-2126

issn

1873-5835

pii

S0145-2126(04)00298-X

journal_volume

29

pub_type

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