Acute promyelocytic leukemia with del(6)(p23).

abstract：:Rhodamine 123 is transported by the transmembrane efflux pump P glycoprotein (Pgp). We used this fluorescent dye to study multidrug resistance (MDR) activity in normal and leukemic CD34+ cells. These immature cells had a high degree of MDR activity. Among leukemic cells, CD34+ leukemias had significantly higher MDR ac...

journal_title：Leukemia research

authors： Drenou B,Fardel O,Amiot L,Fauchet R

更新日期：1993-12-01 00:00:00

abstract：:We have earlier shown that VP-16 combined with Cyclosporin A (CsA) produces tumor specific immunity to L1210 leukemia in BDF/1 mice [Slater LM, Sweet P, Stupecky M, Reynolds JT. Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD(8) T-lymphocytes, Clin Immunol Immunopathol 1995;7...

journal_title：Leukemia research

authors： Slater LM,Stupecky M,Sweet P,Osann KE

更新日期：2002-02-01 00:00:00

abstract：:The technology of array comparative genomic hybridization (array-CGH/aCGH) enabled the identification of novel genomic aberrations in chronic lymphocytic leukemia (CLL) including the monoallelic and biallelic deletions affecting 22q11 locus. In contrast to previous publications, we hypothesized that the described 22q1...

journal_title：Leukemia research

authors： Mraz M,Stano Kozubik K,Plevova K,Musilova K,Tichy B,Borsky M,Kuglik P,Doubek M,Brychtova Y,Mayer J,Pospisilova S

更新日期：2013-07-01 00:00:00

abstract：:Quantitative differences in HLe-1 expression were studied on normal lymphocytes and lymphoblasts of patients with acute lymphoblastic leukemia (ALL). A relationship was found between quantitative antigen expression and therapeutic outcome. Alterations in fluorescence intensity (FI) were demonstrated using quantitative...

journal_title：Leukemia research

authors： Caldwell CW,Patterson WP,Hakami N

更新日期：1987-01-01 00:00:00

abstract：:The incidence of B cell chronic lymphocytic leukemia (B-CLL) is lower in Asian countries, including India, when compared with Western countries. The bcl-2 gene rearrangement was restricted to the 5' region and seen in only one of the 20 Indian patients analyzed. The incidence remains similar to that reported from West...

journal_title：Leukemia research

authors： Parikh PM,Desai S,Naresh KN,Shakuntaka B,Laxminarayan K,Nair CN,Ladanyi M,Soman CS,Advani SH,Chaganti RS

更新日期：1996-09-01 00:00:00

abstract：:AKT1 is the human homolog of the v-akt oncogene. AKT1 has two distinct protein domains, one serine/threonine kinase domain and one pleckstrin homology (PH) domain. We studied the expression and activity of AKT1 in hematopoietic cell lines. The expression of AKT1 was constitutive in hematopoietic cells of various stage...

journal_title：Leukemia research

authors： Zhang X,Vik TA

更新日期：1997-09-01 00:00:00

abstract：:The tumor microenvironment (TME) is critical to the longevity of tumor B cells in chronic lymphocytic leukemia (CLL). Bone marrow mesenchymal stem cells (BMMSCs) and the cytokines they produce including IL-6 are important components of the TME in CLL. We found BMMSCs supported the survival of CLL cells in vitro throug...

journal_title：Leukemia research

authors： Zhu F,McCaw L,Spaner DE,Gorczynski RM

更新日期：2018-03-01 00:00:00

abstract：:We investigated the effects of two sex steroids (17beta estradiol and testosterone) on five human leukemia cell lines. We observed a statistically significant inhibition of proliferation, dose and time dependent, of the human monoblastic leukemia cell line U937. This inhibition was associated with a dose dependent dec...

journal_title：Leukemia research

authors： Mossuz P,Cousin F,Castinel A,Chauvet M,Sotto MF,Polack B,Sotto JJ,Kolodie L

更新日期：1998-11-01 00:00:00

abstract：:Pycnogenol, rich of many phytochemicals of medical value, is a commercialized nutrient supplement extracted from the bark of European coastal pine. In this study, we investigated the anti-tumor effects of Pycnogenol on HL-60, U937 and K562 human leukemia cell lines. We found that Pycnogenol inhibited cell proliferatio...

journal_title：Leukemia research

authors： Huang WW,Yang JS,Lin CF,Ho WJ,Lee MR

更新日期：2005-06-01 00:00:00

abstract：:We established a plasmacytoid dendritic cell (pDC) line (PMDC05) from leukemia cells of pDC leukemia. PMDC05 cells were positive for CD4, CD56, CD33, HLA-DR, CD123 (IL-3Ralpha) and CD86 in the absence of lineage markers. mRNA of TLR1, TLR2, TLR4, TLR7 and TLR9 was clearly expressed and among these TLRs, TLR7 was promi...

journal_title：Leukemia research

authors： Narita M,Watanabe N,Yamahira A,Hashimoto S,Tochiki N,Saitoh A,Kaji M,Nakamura T,Furukawa T,Toba K,Fuse I,Aizawa Y,Takahashi M

更新日期：2009-09-01 00:00:00

abstract：:Leukemic cells from 85 children with newly diagnosed precursor B-lineage ALL were tested for in vitro drug sensitivity to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. There was a significant correlation between MRD day 29 and in vitro sensitivity to prednisolone (p<0.001) and do...

journal_title：Leukemia research

authors： Lönnerholm G,Thörn I,Sundström C,Frost BM,Abrahamsson J,Behrendtz M,Heldrup J,Jacobsson S,Li A,Olofsson T,Porwit A,Söderhäll S,Larsson R,Forestier E

更新日期：2009-01-01 00:00:00

abstract：:Essential thrombocythemia (ET) is an uncommon chronic myeloproliferative disorder with no cure. Patients with ET are at risk of different complications, and currently there are no optimal prognostic standards to predict severe post-diagnosis complications such as thrombosis and hemorrhage. In this study, we retrospect...

journal_title：Leukemia research

authors： Zhou D,Chen W,Cheng H,Qiao JL,Zhu LL,Li ZY,Xu KL

更新日期：2018-06-01 00:00:00

abstract：:A number of inborn errors of purine metabolism have been associated with immunodeficiency diseases. From studies to the possible mechanism(s) leading to the defects in the immune system, it appeared that the accumulation of deoxyATP and deoxyGTP and the subsequent inhibition of ribonucleotide reductase played an impor...

journal_title：Leukemia research

authors： van Laarhoven JP,de Bruyn CH

更新日期：1983-01-01 00:00:00

abstract：:The impact of socioeconomic status (SES) upon childhood cancer outcomes has not been extensively examined. Our objective was to determine the association between SES and event-free survival (EFS) among children with acute lymphoblastic leukemia (ALL) diagnosed in Ontario, Canada from 1995-2011 (N=1541) using Cox propo...

journal_title：Leukemia research

authors： Gupta S,Sutradhar R,Guttmann A,Sung L,Pole JD

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To analyze the frequency, clinical characteristics, and prognosis of IGH deletion in multiple myeloma (MM). METHODS:A total of 310 consecutive patients with multiple myeloma were analyzed. Among them 251 patients were newly diagnosed and 59 patients were previously treated, fluorescence in situ hybridization...

journal_title：Leukemia research

authors： He H,Fu W,Jiang H,Du J,Zhou L,Zhang C,Xi H,Li R,Hou J

更新日期：2015-05-01 00:00:00

abstract：:The MYBL2 gene encodes a transcription factor implicated in cell proliferation and maturation whose amplification or overexpression has been associated with different human malignancies, suggesting that it could be implicated in tumorigenesis. We analyzed MYBL2 expression and its prognostic value in 291 patients with ...

journal_title：Leukemia research

authors： Fuster O,Llop M,Dolz S,García P,Such E,Ibáñez M,Luna I,Gómez I,López M,Cervera J,Montesinos P,Moscardó F,Cordón L,Solves P,de Juan I,Palanca S,Bolufer P,Sanz MÁ,Barragán E

更新日期：2013-12-01 00:00:00

abstract：:We evaluated outcomes in two consecutive groups of AML patients age>60 years in CR after 7+3 induction therapy. Group 1 received consolidation with cytarabine 1.5g/m(2) q12h×6+daunorubicin for two cycles, while group 2 received consolidation with 7+3 followed by mitoxantrone+etoposide. For patients with intermediate-r...

journal_title：Leukemia research

authors： Hassanein M,Atenafu EG,Schuh AC,Yee KW,Minden MD,Schimmer AD,Gupta V,Brandwein JM

更新日期：2013-05-01 00:00:00

abstract：:Semenogelin (SEMG) I is a Cancer-Testis (CT) antigen that we have found to be expressed in myeloma cells. In this study, we set out to determine whether the expression of SEMG I could be upregulated pharmacologically. We found that SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6. ...

journal_title：Leukemia research

authors： Zhang Y,Wang Z,Zhang J,Farmer B,Lim SH

更新日期：2008-12-01 00:00:00

abstract：:Angiogenesis is a complex process controlled by the balance of a large number of regulating factors, the pro- and anti-angiogenic factors. Dysregulation of angiogenesis occurs in various pathologies and is one of the hallmarks for cancer. Recent emphasis on the microenvironment's influence in chronic lymphocytic leuke...

journal_title：Leukemia research

authors： Xia Y,Lu RN,Li J

更新日期：2012-10-01 00:00:00

abstract：:It has become routine practice to culture bone marrow and/or unstimulated peripheral blood for cytogenetic analysis due to associations of consistent chromosomal abnormalities within specific subgroups of leukemias. Unfortunately, two leukemias for which numerous chromosomal aberrations have been recorded, acute myelo...

journal_title：Leukemia research

authors： Macera MJ,Szabo P,Verma RS

更新日期：1989-01-01 00:00:00

abstract：:A total of 854 patients with anti-HTLV-I antibody positive ATL, newly diagnosed from 1983 to 1987, were analyzed for prognostic factors. There were 466 males and 388 females with a mean age of 57.1. Of these 269 (31.5%) were alive with a median follow-up time of 14 months from diagnosis, while 585 (65.5%) were dead wi...

journal_title：Leukemia research

authors：

更新日期：1991-01-01 00:00:00

abstract：:Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS (MDS-AML) present high expression of leukemia inhibitor factor (LIF). We demonstrated using mitogen-activated protein kinase (MAPK) inhibitors that in stromal cells from pediatric MDS and MDS-AML, p38MAPK ...

journal_title：Leukemia research

authors： da Costa SV,Roela RA,Junqueira MS,Arantes C,Brentani MM

更新日期：2010-04-01 00:00:00

abstract：:Plasma levels of beta-2 microglobulin (beta2M), a subunit of the human leukocyte antigen-class I (HLA-I) molecule, correlate negatively with outcome in non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD). We examined the clinical relevance of soluble HLA-I (sHLA-I) levels in NHL and HD. Sera from consecutive NHL (...

journal_title：Leukemia research

authors： Albitar M,Vose JM,Johnson MM,Do KA,Day A,Jilani I,Kantarjian H,Keating M,O'Brien SM,Verstovsek S,Armitage JO,Giles FJ

更新日期：2007-02-01 00:00:00

abstract：:We have previously shown that forced expression of the transcription factor Scl in WEHI-3B D(+) cells prevents ATRA-induced cell differentiation. We now find that the overexpression of Rbtn2 also interferes with induction of differentiation by ATRA. Addition of LiCl to ATRA treatment restored the capacity of both Scl-...

journal_title：Leukemia research

authors： Rice AM,Li J,Sartorelli AC

更新日期：2004-04-01 00:00:00

abstract：:AML progenitor cells (AML-PC) undergo significant apoptosis in response to the deacetylase inhibitor (DACi) LAQ824 and lose the replating capacity which was not observed with the DACi valproic acid. Treatment of normal hematopoietic progenitor cells (HPC) with LAQ824 resulted in (i) inhibition of differentiation, (ii)...

journal_title：Leukemia research

authors： Schwarz K,Romanski A,Puccetti E,Wietbrauk S,Vogel A,Keller M,Scott JW,Serve H,Bug G

更新日期：2011-01-01 00:00:00

abstract：:Although verapamil, cyclosporin A. cremophor EL and PSC-833 are active as multidrug resistance modulators, there has been limited study of these compounds as possible chemotherapy enhancing agents against drug-sensitive tumors. We compared these agents as modifiers of VP-16 cytotoxicity in vitro and modifiers of VP-16...

journal_title：Leukemia research

authors： Slater L,Sweet P,Wetzel M,Stupecky M,Osann K

更新日期：1995-08-01 00:00:00

abstract：:Telomere dysfunction might generate genomic instability leading to the progression of myelodysplastic syndromes (MDS) into acute myeloid leukemia (AML). We investigated telomere length (TL), telomerase activity (TA) and hTERT, c-myc, mad1, and p53 expression in the bone marrow of patients with MDS (n=109), AML (n=47) ...

journal_title：Leukemia research

authors： Poloni A,Serrani F,Berardinelli E,Maurizi G,Mariani M,Costantini B,Trappolini S,Mancini S,Olivieri A,Leoni P

更新日期：2013-11-01 00:00:00

abstract：:Mutations in Janus kinase 2 (JAK2) are implicated in the pathogenesis of Philadelphia-chromosome negative myeloproliferative neoplasms, including primary myelofibrosis, polycythemia vera, and essential thrombocythemia. Gandotinib (LY2784544), a potent inhibitor of JAK2 activity, shows increased potency for the JAK2V61...

journal_title：Leukemia research

authors： Verstovsek S,Mesa RA,Salama ME,Li L,Pitou C,Nunes FP,Price GL,Giles JL,D'Souza DN,Walgren RA,Prchal JT

更新日期：2017-10-01 00:00:00

abstract：:Many evidences have shown that dietary intake of cruciferous vegetables could protect against the risk of various types of malignancies. Benzyl isothiocyanate (BITC), one of the compounds from cruciferous vegetables, had shown induced cell cycle arrest and apoptosis in cancer cells. However, there is no available info...

journal_title：Leukemia research

authors： Tsou MF,Peng CT,Shih MC,Yang JS,Lu CC,Chiang JH,Wu CL,Lin JP,Lo C,Fan MJ,Chung JG

更新日期：2009-11-01 00:00:00

abstract：:Chromosomal changes are necessary in determining the classification, prognosis and using the appropriate therapeutic regimen in acute leukemia. Isochromosomes are uncommon chromosome aberations in childhood acute lymphoblastic leukemia (ALL) and the effect of i(9q) is not well established. We present an 8-year-old mal...

journal_title：Leukemia research

authors： Cogulu O,Karapinar DY,Karaca E,Aydinok Y,Ozkinay F

更新日期：2006-11-01 00:00:00